2001
DOI: 10.1046/j.1471-4159.2001.00633.x
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Presence of NK2 binding sites in the rat brain

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Cited by 32 publications
(7 citation statements)
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“…On the basis of identified NK 2 ‐ and NK 3 ‐R in the medial septum (Shughrue et al, 1996; Saffroy et al, 2001) and on Steinberg et al's (1998) results, we hypothesized that injection of the endogenous NK 2 ‐ and NK 3 ‐R agonists, respectively, NKA and NKB, into the medial septum would increase extracellular ACh in the hippocampus, as assessed by in vivo microdialysis and HPLC. In fact, we found that both neurokinins enhanced ACh release, not only in the hippocampus, but also in the amygdale, but not in the frontal cortex.…”
Section: Discussionmentioning
confidence: 94%
“…On the basis of identified NK 2 ‐ and NK 3 ‐R in the medial septum (Shughrue et al, 1996; Saffroy et al, 2001) and on Steinberg et al's (1998) results, we hypothesized that injection of the endogenous NK 2 ‐ and NK 3 ‐R agonists, respectively, NKA and NKB, into the medial septum would increase extracellular ACh in the hippocampus, as assessed by in vivo microdialysis and HPLC. In fact, we found that both neurokinins enhanced ACh release, not only in the hippocampus, but also in the amygdale, but not in the frontal cortex.…”
Section: Discussionmentioning
confidence: 94%
“…Apparently, blockade of NK 2 receptors does not inhibit the initial magnitude of the HR increase induced by pain, but reduces the duration of the response. NK2 binding sites were detected in few brain structures, including the hippocampus, the septum the thalamus and the prefrontal cortex (19–21). Pharmacological studies also support the presence of NK 2 receptors in the brain (22).…”
Section: Discussionmentioning
confidence: 99%
“…NK1 receptors have been identified in the brains of gerbils and humans with a content up to 607 and 432 fmoles/mg, respectively [44], whereas NK2 and NK3 receptors achieve only 7.3 (rat) [117] and 31.2 fmoles/mg [59] [118], respectively. For the NK1 receptor the sequence of affinities of the preferred neurokinins is SP = HK-1 > NPG > NKA = NPK > NKB [184] [197].…”
Section: Mammalian Neurokinins and Their Receptorsmentioning
confidence: 99%