“…Dopamine binds to D 2 receptors to inhibit L-type Ca 2+ channels in rat isolated glomus cells and to 60 decrease acetylcholine release from rabbit CBs (Benot and López-Barneo, 1990; Kim et al, 2004). Existence of dopamine D 2 receptors in CBs has been confirmed (Lazanov et al, 2009;Kåhlin et al, 2010). Moreover, in vivo experiments demonstrated that dopamine is released from glomus cells during Page 4 of 30 A c c e p t e d M a n u s c r i p t Wakai J. et al,Page 4 hypoxia (Fidone et al, 1982;Iturriaga and Alcayaga, 1998;Buerk et al, 1998;65 Wang and Bisgard, 2002;Powell, 2007), and dopamine content in the CB is increased by exposure to sustained hypoxia for 2-28 days (Hanbauer et al, 1981;Olson et al, 1983;Pequignot et al, 1987;Hui et al, 2003).…”