Presence of NGAL/MMP-9 complexes in human abdominal aortic aneurysms

Folkesson, Maggie; Kazi, Monsur; Zhu, Chaoyong; Swedenborg, Jesper; Eriksson, Per; Hedin, Ulf; Hamsten, Anders

doi:10.1016/j.vph.2006.08.381

Cited by 37 publications

(47 citation statements)

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“…3). Zymography of protein extracts from lung and spleen of mice injected with 1A9-VAS-3 showed a gelatinolytic band with an apparent molecular weight of 130 kDa, possibly representing a homodimer of the 68 kDa spontaneously truncated pro-MMP9 (19), or a complex of MMP9 with a 2 -microglobulin -related protein (20) or lipocalin (21). The ovaries of tumor-bearing mice had a peculiar gelatinolytic profile.…”

Section: Tumor-derived Vegf Influences Gelatinase Expression In Endotmentioning

confidence: 99%

Vascular Endothelial Growth Factor Stimulates Organ-Specific Host Matrix Metalloproteinase-9 Expression and Ovarian Cancer Invasion

Belotti

Calcagno

Garofalo

et al. 2008

Molecular Cancer Research

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Vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP) regulate each other, contributing to tumor progression. We have previously reported that MMP9 induces the release of tumor VEGF, promoting ascites formation in human ovarian carcinoma xenografts. The aim of this study was to investigate whether tumor-derived VEGF regulated the expression of gelatinase by the stroma, influencing the invasive properties of ovarian tumors. Tumor variants derived from 1A9 human ovarian carcinoma, stably expressing VEGF 121 in the sense (1A9-VS-1) and antisense orientations (1A9-VAS-3), were used. In vivo, zymographic analysis of tumors from 1A9-VS-1 implanted in the peritoneal cavity of nude mice showed higher levels of gelatinases, particularly murine MMP9, indicating that VEGF stimulates host expression of the matrix-degrading enzyme. Murine MMP9 expression was also high in the ovaries of mice bearing 1A9-VS-1 tumors. The effect on host MMP9 activity was organ-specific. The levels of host pro-MMP9 in ovaries correlated with the plasma levels of tumor VEGF and with the selective invasion of the ovaries. Induction of host MMP9 expression in tumors and ovaries was independent of the site of tumor growth as it was seen in mice carrying both intraperitoneal and subcutaneous tumors. The anti-VEGF antibody bevacizumab (Avastin) inhibited MMP9 expression and tumor invasion in the ovaries of mice bearing 1A9-VS-1 tumors. These findings point to a complex cross-talk between VEGF and MMPs in the progression of ovarian tumor and suggest the possibility of using VEGF inhibitors to affect MMP-dependent tumor invasion.

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Section: Tumor-derived Vegf Influences Gelatinase Expression In Endotmentioning

confidence: 99%

Vascular Endothelial Growth Factor Stimulates Organ-Specific Host Matrix Metalloproteinase-9 Expression and Ovarian Cancer Invasion

Belotti

Calcagno

Garofalo

et al. 2008

Molecular Cancer Research

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“…Secondly, through the junction with MMP-9, the degradation of the latter is inhibited, thereby preserving enzymatic activity. In this way, further proteolytic degradation of elastin takes place, thus leading to the growth of the AAA [25]. Upregulation of both MMP-9 and NGAL is induced by c-Jun N-terminal-kinase (JNK), which is involved in cellular stress responses and has been shown to be an important signaling molecule in the pathogenesis of AAA [26].…”

Section: Resultsmentioning

confidence: 99%

“…Finally, Folkesson et al [25] came to the conclusion that the concentration of the NGAL/MMP-9 complex was highest in the luminal part of the thrombus. Neutrophil-derived NGAL could enhance the proteolytic activity associated with AAA, but the importance of this mechanism for aneurysm growth remains to be shown [25].…”

Section: Ngal and Aaa Natural Historymentioning

confidence: 99%

“…Table 1 summarizes the role of NGAL in the natural history of AAA. • In complex with MMP-9 is found in higher amounts in AAA patients • does not correlate with either maximal aortic diameter or maximal ILT thickness (p=0.8 and 0.2 respectively) Folkesson [25] 2007 Presence of NGAL/MMP-9 complexes in human AAA…”

Section: Ngal and Aaa Natural Historymentioning

confidence: 99%

“…Neutrophil-derived NGAL could enhance the proteolytic activity associated with AAA, but the importance of this mechanism for aneurysm growth remains to be shown [25].…”

Section: Ngal and Aaa Natural Historymentioning

confidence: 99%

See 2 more Smart Citations

Neutrophil Gelatinase Associated Lipocalin (NGAL) as a Biomarker. Does It Apply in Abdominal Aortic Aneurysms? A Review of Literature

Karaolanis

Moris²,

Palla

et al. 2014

Indian J Surg

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Neutrophil gelatinase associated lipocalin (NGAL) as a protein derived from neutrophils has recently been the field of investigation in a wide range of diseases (renal disease, coronary artery disease, etc). The MEDLINE/PubMed database was searched for publications with the medical subject heading "NGAL" and keywords "Abdominal aortic aneurysm (AAA)," "biomarker," and "growth". We restricted our search to date. In this review, we included 38 articles and abstracts that were accessible and available in English. An effort to further explain the role of NGAL within AAA has been made. NGAL seems to be a hopeful marker for the pathogenesis and the progression of abdominal aortic aneurysms (AAAs), which has significant morbidity and mortality rates.

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MiRNA‐181a is a novel regulator of aldosterone–mineralocorticoid receptor‐mediated cardiac remodelling

Garg

Foinquinos

Jung

et al. 2020

European J of Heart Fail

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The aldosterone-mineralocorticoid receptor (Aldo-MR) pathway is activated during cardiac stress, such as hypertension, myocardial infarction (MI), and heart failure. The importance of Aldo and MR in the pathogenesis of cardiac diseases is well established; however, the regulatory mechanisms behind Aldo/MR-induced cardiac remodelling remain uncertain. We here investigated potential miRNA-mediated regulation of the Aldo-MR pathway to improve mechanistic understanding.

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Presence of NGAL/MMP-9 complexes in human abdominal aortic aneurysms

Cited by 37 publications

References 0 publications

Vascular Endothelial Growth Factor Stimulates Organ-Specific Host Matrix Metalloproteinase-9 Expression and Ovarian Cancer Invasion

Vascular Endothelial Growth Factor Stimulates Organ-Specific Host Matrix Metalloproteinase-9 Expression and Ovarian Cancer Invasion

Neutrophil Gelatinase Associated Lipocalin (NGAL) as a Biomarker. Does It Apply in Abdominal Aortic Aneurysms? A Review of Literature

MiRNA‐181a is a novel regulator of aldosterone–mineralocorticoid receptor‐mediated cardiac remodelling

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