Presence of Monoaminergic Neurons in the Spinal Cord and Intestine of the Lamprey, &lt;i&gt;Lampetra japonica&lt;/i&gt;

Honma, Shinji

doi:10.1679/aohc1950.32.383

Cited by 38 publications

(6 citation statements)

References 26 publications

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“…Such cells have been reported for the lamprey, Lampetra, (Honma 1970) and other fishes (Acipenser, Kotrschal et al, 1985;Lepisosteus, Parent and Northcutt, 1982;Esox, Baumgarten et al, 1970;Hydrolagus, Squalus, Steusse andCruce, 1991, 19921, various amphibians (Rana, Nagatsu et al, 1982;Cheder and Nicholson, 1985;Triturus, Franzoni et al, 19861, a reptile (Varanus, Wolters et al, 1984), and the chick (Wallace et al, 1987). Our previous work on Raja (Roberts and Meredith, 19871, and the current study on Anguilla and Oncorhynchus, suggest, at least for these species, that the catecholamine is dopamine; if this conclusion is applicable to the other vertebrates in which THimmunopositive cells have been demonstrated, it would seem that there is a set of central canal neurons synthesizing dopamine that is to be found in all classes of nonmammalian vertebrates.…”

Section: Central Canal Liquor-contacting Neuronssupporting

confidence: 57%

Dopaminergic and GABAergic cerebrospinal fluid‐contacting neurons along the central canal of the spinal cord of the eel and trout

Roberts

Maslam

Scholten

et al. 1995

J of Comparative Neurology

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In anamniote vertebrates the central region of the spinal cord has been implicated in its regeneration. This is a complex region and so as a first step in understanding its possible regenerative role we have examined the organization of the cells that contact the lumen of the spinal cord in two teleost fishes, eel and trout, using immunohistochemical procedures and light and electron microscopy. Cell bodies immunoreacting positively with antibodies for tyrosine hydroxylase and for dopamine were located at the ventral rim of the central canal, whereas cell bodies reacting for an antibody for gamma-aminobutyric acid were more laterally located. None of the canal-contacting cells were positively immunoreactive for choline acetyltransferase. All immunopositive cells have a similar morphology: the amphora-shaped perikaryon is bipolar and has a single process that extends to the lumen of the canal, and another that branches and forms extensive lateral and ventral plexuses. Electron microscopic investigations of the ventral dopaminergic cells showed that the apical processes bear one or more cilia, which protrude into the canal lumen and which originate from within a superficial rosette of nonciliated processes. The ventral process was occasionally seen to form synapses; the cell body was also the target of synapses.

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Section: Central Canal Liquor-contacting Neuronssupporting

confidence: 57%

Dopaminergic and GABAergic cerebrospinal fluid‐contacting neurons along the central canal of the spinal cord of the eel and trout

Roberts

Maslam

Scholten

et al. 1995

J of Comparative Neurology

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“…Aminergic terminals contacting the basal lamina have been observed in the lamprey spinal cord (Ochi et al 1979), and terminals of similar appearance contacting the external surface of the caudal spinal cord have also been found in elasmobranchs and teleosts (Vigh et al 1974. In some vertebrate species, aminergic neurons have also been observed in the spinal cord (Honma 1970;Ochi & Hosoya 1974;Ochi et al 1979;Parent & Northcutt 1982;Kotrschal et al 1985;Roberts & Meredith 1987), but we do not know the origin of these putative aminergic fibres in the amphioxus FT.…”

Section: Transition Of the Ft To The Caudal Spinal Cordmentioning

confidence: 82%

Ultrastructural Study of the Filum Terminate and Caudal Ampulla of the Spinal Cord of Amphioxus (Branchiostoma lanceolatum Pallas)

Ruiz

Anadón

1991

Acta Zoologica

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The filum terminale and caudal ampulla of amphioxus were studied by electron microscopy. The filum terminale consists of ependymal cells whose cilia are directed caudally. Remarkably, nerve fibres course through the filum terminale and caudal ampulla and end on the basal lamina forming neuro‐connective structures. Moreover, these nerve boutons are divisible into several classes according to their vesicle content. Boutons containing large dense‐cored vesicles are very similar in appearance to the neurosecretory terminals found in the caudal spinal cord of some vertebrates. These observations on nerve fibres suggest that a primitive neurosecretory system similar to the fish urophysis is present in the amphioxus.

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“…In the lamprey, segmental DA and 5-HT neurons appear to play an important role in controlling the spinal interneuronal network generating locomotor activity. A prominent system of segmental 5-HT neurons is distributed in the midline area (Honma, 1970;Ochi et al, 1979;Van Dongen et al, 1985b;Harris-Warrick et al, 1985). These multipolar neurons give rise to a dense plexus of varicose fibers in the ventromedial spinal cord, into which locomotor network interneurons and motoneurons extend their medial dendrites (Van Dongen et al, 1985a).…”

mentioning

confidence: 99%

Synaptic and nonsynaptic monoaminergic neuron systems in the lamprey spinal cord

et al. 1996

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In the lamprey spinal cord, dopamine- (DA) and 5-hydroxytryptamine-(5-HT) containing cells appear to play an important role in controlling the firing properties of motoneurons and interneurons and, thereby, in modulating the efferent motor pattern. To determine the detailed morphology and synaptic connectivity of the intraspinal DA and 5-HT systems in Lampetra fluviatilis and Ichthyomyzon unicuspis, DA and 5-HT antisera were used in light and electron microscopic immunocytochemical experiments. Two main groups of labeled cells were distinguished: DA-containing liquor-contacting (LC) cells distributed along the central canal, and 5-HT+DA-containing multipolar cells located near the midline ventral to the central canal. Both types were synaptically connected with other neuronal elements. The DA-immunoreactive LC cells, which extended a ciliated process into the central canal, received symmetrical synapses from unlabeled terminals containing small synaptic vesicles. The distal process of the LC cells could be traced to the lateral cell column, to the ventral aspect of the dorsal column, or to the ventromedial area. Ultrastructural analysis of DA fibers in these regions showed the presence of labeled terminals containing numerous small synaptic vesicles and a few dense-core vesicles. These terminals formed symmetrical synapses with unlabeled cell bodies and dendrites, with GABA-immunopositive LC cells, and with the multipolar DA+5-HT cells. The multipolar DA+5-HT cells also received input from unlabeled synapses. Intracellular recording from these cells showed that they received excitatory postsynaptic potentials in response to stimulation of fibers in the ventromedial tracts and dorsal roots. The terminals of the multipolar DA+5-HT neurons in the ventromedial spinal cord contained numerous dense-core vesicles and small synaptic vesicles, but no synaptic specializations could be detected. In addition, a small number of larger DA-immunoreactive cells were observed in the lateral cell column at rostral levels. The lamprey spinal cord thus contains distinct populations of synaptically interconnected monoaminergic neurons. Dopamine-containing LC cells synapse onto DA+5-HT-containing multipolar cells, in addition to GABAergic LC cells and unidentified spinal neurons. In contrast, the multipolar cells appear to exert their influence by nonsynaptic mechanisms.

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Presence of Monoaminergic Neurons in the Spinal Cord and Intestine of the Lamprey, <i>Lampetra japonica</i>

Cited by 38 publications

References 26 publications

Dopaminergic and GABAergic cerebrospinal fluid‐contacting neurons along the central canal of the spinal cord of the eel and trout

Dopaminergic and GABAergic cerebrospinal fluid‐contacting neurons along the central canal of the spinal cord of the eel and trout

Ultrastructural Study of the Filum Terminate and Caudal Ampulla of the Spinal Cord of Amphioxus (Branchiostoma lanceolatum Pallas)

Synaptic and nonsynaptic monoaminergic neuron systems in the lamprey spinal cord

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