Presence of micropapillary and solid patterns are associated with nodal upstaging and unfavorable prognosis among patient with cT1N0M0 lung adenocarcinoma: a large-scale analysis

Yuan, Yuchao; Ma, Guansheng; Zhang, Ya Qi; Chen, Haiquan

doi:10.1007/s00432-017-2571-7

Cited by 24 publications

(19 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2 The prognostic impact of micropapillary (MP) and/or solid predominant subtype on survival outcomes in lung adenocarcinoma has been demonstrated to be associated with worse prognosis. [3][4][5][6] However, the clinicopathological characteristics and long-term survival in patients with adenocarcinoma harboring a minor proportion of MP component (nonpredominant) remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Prognostic impact of micropapillary component in patients with node‐negative subcentimeter lung adenocarcinoma: A Chinese cohort study

Yao

Zhu

et al. 2020

Thoracic Cancer

View full text Add to dashboard Cite

Background: In this study, we investigated the prognostic significance of a micropapillary (MP) component in patients with subcentimeter lung adenocarcinoma. Methods: A total of 311 patients with subcentimeter lung adenocarcinoma who underwent surgical resection between January 2009 to December 2012 from seven medical centers were included. Recurrence-free survival (RFS) and overall survival (OS) were analyzed. Results: The five-year RFS was 79.8% in 97 (97/311, 31%) cases of adenocarcinoma with a MP component and 93.5% in the 214 (214/311, 69%) cases without. In multivariate analysis, MP was an independent risk factor for worse RFS (hazard ratio [HR], 3.73; 95% confidence interval [CI]: 1.87-7.42; P < 0.001) and OS (HR, 5.84; 95% CI: 2.20-15.49; P < 0.001). There was no significant difference among wedge resection, segmentectomy and lobectomy on RFS (P = 0.256) and OS (P = 0.103) in patients without MP. Regarding patients with a MP component, lobectomy achieved equivalent prognosis than segmentectomy, and both were better than wedge resection (P = 0.001). Conclusions: A MP component still suggest a poor prognosis in subcentimeter lung adenocarcinoma. Patients with subcentimeter lung adenocarcinoma with a MP component of 5% or greater treated with wedge resection were at higher risk of recurrence than patients treated with anatomical resection.

show abstract

Section: Introductionmentioning

confidence: 99%

Prognostic impact of micropapillary component in patients with node‐negative subcentimeter lung adenocarcinoma: A Chinese cohort study

Yao

Zhu

et al. 2020

Thoracic Cancer

View full text Add to dashboard Cite

show abstract

“…In all the four subgroups, the risk of recurrence and death was lower in the adjuvant chemotherapy than in the control group. [8,10]. In our study, only the presence of micropapillary patterns, and not the solid patterns, were analyzed.…”

Section: Subgroup Analysismentioning

confidence: 99%

Clinical efficacy of adjuvant chemotherapy in stage IB (< 4 cm) non-small cell lung cancer patients with high-risk factors

Choi

Lee

et al. 2022

Korean J Intern Med

View full text Add to dashboard Cite

Background/Aims: Adjuvant chemotherapy is the standard of care for resected stage II-IIIA non-small cell lung cancer (NCSLC). The efficacy of adjuvant chemotherapy in stage IB (<4 cm) NSCLC with high-risk factors is controversial. Methods: This retrospective multicenter study included 285 stage IB NSCLC patients with high-risk factors according to the 8 th edition Tumor, Node, Metastasis classification from four academic hospitals. High-risk factors included visceral pleural invasion, vascular invasion, lymphatic invasion, lung neuroendocrine tumors, and micropapillary histology patterns. Results: Of the 285 patients, 127 (44.6%) were included in the adjuvant chemotherapy group and 158 (55.4%) were included in the non-adjuvant chemotherapy group. The median follow-up was 41.5 months. Patients in the adjuvant chemotherapy group had a significantly reduced recurrence rate and risk of mortality than those in the non-adjuvant chemotherapy group (hazards ratio, 0.408; 95% confidence interval, 0.221-0.754; P = 0.004 and hazards ratio, 0.176; 95% confidence interval, 0.057-0.546; P = 0.003, respectively). Adjuvant chemotherapy should be particularly considered for the highrisk factors such as visceral pleural involvement or vascular invasion. Based on the subgroup analysis, adjuvant chemotherapy should be considered when visceral pleural involvement is present, even if the tumor size is <3 cm. Conclusions: Adjuvant chemotherapy may be useful for patients with stage IB NSCLC with high-risk factors and is more relevant for patients with visceral pleural involvement or vascular invasion.

show abstract

“…According to the 2015 World Health Organization Classification of Lung Cancer(2), LUAD is mainly categorized into five histopathological subtypes based on prognosis. Micropapillary and solid patterns are high-risk subtypes with rapid metastatic potential and predict poor prognosis (3,4). Contrarily, lepidic predominant adenocarcinoma shows slow-growth tendency and has favorable prognosis (5).…”

Section: Introductionmentioning

confidence: 99%

Proteomic Analyses Identify Differentially Expressed Proteins and Pathways Between Low-Risk and High-Risk Subtypes of Early-Stage Lung Adenocarcinoma and Their Prognostic Impacts

Zhou

Liu

et al. 2021

Molecular & Cellular Proteomics

View full text Add to dashboard Cite

The histopathological subtype of lung adenocarcinoma (LUAD) is closely associated with prognosis. Micropapillary or solid predominant LUAD tends to relapse after surgery at an early stage, whereas lepidic pattern shows a favorable outcome. However, the molecular mechanism underlying this phenomenon remains unknown. Here, we recruited 31 lepidic predominant LUADs (LR: low-risk subtype group) and 28 micropapillary or solid predominant LUADs (HR: high-risk subtype group). Tissues of these cases were obtained and label-free quantitative proteomic and bioinformatic analyses were performed. Additionally, prognostic impact of targeted proteins was validated using The Cancer Genome Atlas databases (n=492) and tissue microarrays composed of early-stage LUADs (n=228). A total of 192 differentially expressed proteins were identified between tumor tissues of LR and HR and three clusters were identified via hierarchical clustering excluding eight proteins. Cluster 1 (65 proteins) showed a sequential decrease in expression from normal tissues to tumor tissues of LR and then to HR and was predominantly enriched in pathways such as tyrosine metabolism and ECM-receptor interaction, and increased matched mRNA expression of 18 proteins from this cluster predicted favorable prognosis. Cluster 2 (70 proteins) demonstrated a sequential increase in expression from normal tissues to tumor tissues of LR and then to HR and was mainly enriched in pathways such as extracellular organization, DNA replication and cell cycle, and high matched mRNA expression of 25 proteins indicated poor prognosis. Cluster 3 (49 proteins) showed high expression only in LR, with high matched mRNA expression of 20 proteins in this cluster indicating favorable prognosis. Furthermore, high expression of ERO1A and FEN1 at protein level predicted poor prognosis in early-stage LUAD, supporting the mRNA results. In conclusion, we discovered key differentially expressed proteins and pathways between low-risk and high-risk subtypes of early-stage LUAD. Some of these proteins could serve as potential biomarkers in prognostic evaluation.

show abstract

Presence of micropapillary and solid patterns are associated with nodal upstaging and unfavorable prognosis among patient with cT1N0M0 lung adenocarcinoma: a large-scale analysis

Abstract: The analysis of a large-scale cohort demonstrated that the presence of micropapillary and solid patterns significantly increase the risk of nodal upstaging and are independently associated with unfavorable prognosis.

Cited by 24 publications

References 23 publications

Prognostic impact of micropapillary component in patients with node‐negative subcentimeter lung adenocarcinoma: A Chinese cohort study

Prognostic impact of micropapillary component in patients with node‐negative subcentimeter lung adenocarcinoma: A Chinese cohort study

Clinical efficacy of adjuvant chemotherapy in stage IB (< 4 cm) non-small cell lung cancer patients with high-risk factors

Proteomic Analyses Identify Differentially Expressed Proteins and Pathways Between Low-Risk and High-Risk Subtypes of Early-Stage Lung Adenocarcinoma and Their Prognostic Impacts

Contact Info

Product

Resources

About