Presence of mast cells and mast cell degranulation in scalp biopsies of telogen effluvium

Grace, Shane; Sutton, Angela; Abraham, Nina F.; Armbrecht, Eric S.; Vidal, Claudia I.

doi:10.4103/ijt.ijt_43_16

Cited by 13 publications

(9 citation statements)

References 40 publications

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“…In agreement with our study, previous studies showed statistical increase in the serum TGF-β 1 level in AA patients in comparison to controls [32][33][34]. On the other hand, in a study by Tembhre and Sharma, when AA patients were compared to controls, their serum TGF-β 1 levels were considerably lower.…”

Section: Discussionsupporting

confidence: 92%

Expression of Long Noncoding RNA, HOTAIR, and MicroRNA-205 and Their Relation to Transforming Growth Factor β1 in Patients with Alopecia Areata

Mohamad

Khedr

Shaker

et al. 2023

Skin Appendage Disord

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Introduction: Alopecia areata (AA) is a common autoimmune condition that affects anagen hair follicles. The most commonly recognized theory is that it is a T-cell-mediated autoimmune disorder in a genetically susceptible individual. MicroRNAs (miRNAs) and long noncoding RNAs (lncRNAs) were thought to play a function in the pathogenesis. The expression of lncRNA HOTAIR and miRNA-205 and their relation to transforming growth factor β1 (TGF-β1) in AA were not studied. Aim: The aim of the studywas to evaluate the role of miRNA-205, lncRNA, HOTAIR, and TGF-β1 levels in AA pathogenesis, clinical course, and severity of AA. Methods: Two groups of subjects were included in this case-control study: 50 patients with AA and 50 healthy matched controls. miRNA-205 and lncRNA HOTAIR expression levels were assayed using quantitative RT-PCR, while serum levels of TGF-β1 were assayed using ELISA techniques. Results: The serum expression of lncRNA HOTAIR was significantly downregulated in AA patients with a p value < 0.001, while the serum expression of both miRNA-205 and TGF-β1 were significantly upregulated in patients. Discussion/Conclusion: This study highlights the potential role of high serum expression of miRNA-205 and TGF-β1 and the low serum expression of lncRNA HOTAIR in AA pathogenesis. This could be used as a therapeutic target to treat AA.

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Section: Discussionsupporting

confidence: 92%

Expression of Long Noncoding RNA, HOTAIR, and MicroRNA-205 and Their Relation to Transforming Growth Factor β1 in Patients with Alopecia Areata

Mohamad

Khedr

Shaker

et al. 2023

Skin Appendage Disord

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“…Grace et al . [ 10 ] also evaluated the follicular and non-follicular mast cell counts in patients with AA and AGA and reported similar mast cell counts with our results. Correspondingly, in their study, AA and AGA patients had significantly higher follicular and non-follicular mast cell counts than the healthy group.…”

Section: Discussionsupporting

confidence: 80%

“…Mast cells in mammalian skin are located in the dermis and subcutaneous tissue, especially in the connective tissue sheath of hair follicles and are involved in the hair folliclecycle [ 12 - 14 ]. A few studies have reported an increase in the number of mast cells in the perifollicular and perivascular in AA lesions [ 10 , 15 , 16 ]. Due to the importance of mast cells in non-scarring alopecias, the current study investigated the number of perifollicular and perivascular mast cells in AA and AGA lesions and compared them with healthy condition.…”

Section: Discussionmentioning

confidence: 99%

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Infiltration of Mast Cells in Scalp Biopsies of Patients with Alopecia Areata or Androgenic Alopecia Versus Healthy Individuals: A Case-Control Study

Nasiri

Salehi

Rakhshan

2020

GMJ

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Background: Alopecia areata (AA) and androgenic alopecia (AGA) are the most common types of alopecias. Recently, the role of mast cells in inflammatory diseases has become the focus of many studies. However, few studies have been conducted on their role in AA and AGA. Therefore, our study aimed to quantitatively evaluate the presence of mast cells in the AA and AGA specimens.Materials and Methods: Three groups of AA, AGA, and healthy control were studied (each group with 20 subjects). Patients were randomly selected from those referred to the dermatology clinics of Shahid Beheshti University. Specimens were obtained from the scalp, and perifollicular and perivascular areas were investigated. Results: Significantly higher perifollicular and perivascular mast cell counts were seen in both AGA and AA groups compared to healthy control (P<0.001 for both). Moreover, AA patients had more frequent perivascular mast cells than the AGA group (P=0.042). Among patients aged <40 years, perifollicular and perivascular mast cell counts were not significantly different among the three groups; however, subjects over 40 years of age in both groups had significantly more perifollicular and perivascular mast cells than healthy participants. There was a significant positive correlation between disease severity and mast cell counts in both perifollicular and perivascular areas in AA patients (P=0.001 for both). Conclusion: There was a significantly increased infiltration of mast cells in AA and AGA patients, and this increase was age and severity dependent. Moreover, the increase in mast cell proliferation is more dominant in AA patients. [GMJ.2020;9:e1962]

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“…[45][46][47] Telogen effluvium TE is a common non-scarring alopecia that mainly affects women. [47][48][49][50] It consists of diffuse hair loss occurring 2-3 months after a triggering event and lasting about 6 months; this hair loss leads to an abnormal shift of scalp hair follicles from anagen to telogen, resulting in premature hair shedding. [47][48][49] TE can be caused by low ferritin, vitamin B12 deficiency, thyroid dysfunctions, systemic diseases, drugs, medications, fever, stress, weight loss and giving birth.…”

Section: Non-scarring Alopeciamentioning

confidence: 99%

An Update on Alopecia and its Association With Thyroid Autoimmune Diseases

Aboalola,

Aouabdi,

Ramadan

et al. 2023

touchREVIEWS in Endocrinology

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Alopecia is comorbid with several illnesses, including various autoimmune conditions such as thyroid disease. Leukocyte-mediated inflammation of hair follicles in alopecia was first described over a century ago. However, the high prevalence of the role of thyroid autoimmune disease in the pathogenesis of alopecia has only recently come to light, together with a strong association between the two. Therefore, this review focuses on articles published between 2011 and 2022 on alopecia's association with thyroid autoimmune disease, and the mechanism behind it. In addition, it highlights the link between alopecia and thyroid cancer, as patients with alopecia have increased risk of thyroid cancer. In conclusion, this comprehensive, focused, scoping review will serve as a reference highlighting recent information on alopecia, exploring its association with thyroid autoimmune diseases.

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Presence of mast cells and mast cell degranulation in scalp biopsies of telogen effluvium

Cited by 13 publications

References 40 publications

Expression of Long Noncoding RNA, HOTAIR, and MicroRNA-205 and Their Relation to Transforming Growth Factor β1 in Patients with Alopecia Areata

Expression of Long Noncoding RNA, HOTAIR, and MicroRNA-205 and Their Relation to Transforming Growth Factor β1 in Patients with Alopecia Areata

Infiltration of Mast Cells in Scalp Biopsies of Patients with Alopecia Areata or Androgenic Alopecia Versus Healthy Individuals: A Case-Control Study

An Update on Alopecia and its Association With Thyroid Autoimmune Diseases

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