1959
DOI: 10.1038/icb.1959.20
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Presence of K‐virus in Wild Mice in Australia

Abstract: A virus, which causes fatal pneumonitis in suckling mice, was isolated from tliree of nine Mu» musculus trapped in a food-processing factory. Twentj'-four A/tw mitsculus from other soiurces around Brisbane were examined, but there were no isolations of the vims.It is indistinguishable irnmunologicutly and histopathologically from K-vinu.

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Cited by 25 publications
(12 citation statements)
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“…Viral replication during acute K virus infection occurs almost exclusively in vascular endothelial cells, and renal involvement is confined to endothelia of glomerular and parenchymal capillaries (Fisher & Kilham, 1953;Kilham & Murphy, 1953;Holt, 1959;Greenlee, 1979Greenlee, , 1981Mokhtarian & Shah, 1980). The finding that nude mice inoculated with K virus develop extensive involvement of renal tubular epithelial cells is thus of interest, since it demonstrates that the cellular tropism of papovaviruses may change during chronic infection.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Viral replication during acute K virus infection occurs almost exclusively in vascular endothelial cells, and renal involvement is confined to endothelia of glomerular and parenchymal capillaries (Fisher & Kilham, 1953;Kilham & Murphy, 1953;Holt, 1959;Greenlee, 1979Greenlee, , 1981Mokhtarian & Shah, 1980). The finding that nude mice inoculated with K virus develop extensive involvement of renal tubular epithelial cells is thus of interest, since it demonstrates that the cellular tropism of papovaviruses may change during chronic infection.…”
Section: Discussionmentioning
confidence: 99%
“…K virus infection of suckling mice is characterized by extensive infection of pulmonary and systemic vascular endothelial cells. Death results from interstitial pneumonia (Fisher & Kilham, 1953;Kilham & Murphy, 1953;Greenlee, 1979;Holt, 1959;Mokhtarian & Shah, 1980). In older suckling mice, K virus produces a protracted infection in which virus and/or viral antigen can be detected in several organs for as long as 4 months (Greenlee, 1981).…”
Section: Introductionmentioning
confidence: 99%
“…Three biweekly injections of culture fluids from untransfected q-2 cells, which contain high levels of RNA-free virions, were given to 10 (Table 3).…”
Section: Methodsmentioning
confidence: 99%
“…They were used as dilutions of clarified supernatants from 10% (wt/vol) homogenates of the greatly enlarged spleens of mice infected 12-15 days earlier as described (15). Stocks were titrated by the spleen focus method (16) competent FMuLV proviral genome in clone 2-lalc (10) to produce pKR4 (see Fig. 1 Cytolytic T-lymphocyte (CTL) responses were determined using 51Cr-labeled Df45 cells as targets as described (18).…”
Section: Methodsmentioning
confidence: 99%
“…Serially passaged Epo virus (obtained by homogenizing infected spleens in 10 vol of 0.02 M Tris HCl, pH 7.4/0.10 M NaCl/0.001 M EDTA and centrifuging twice at 10,000 x g for 15 min) was stored at -70'C. Passaged Friend virus (Lilly-Steeves polycythemia strain) was also from spleen homogenates (14). Mouse strains included NFS/N, DBA/2J (both Fv-2s), and the Fv-2r congenic strain D2.B6-Fv-2r (D2.R).…”
mentioning
confidence: 99%