Presence of JP2 and Non‐JP2 Genotypes of <i>Aggregatibacter actinomycetemcomitans</i> and Attachment Loss in Adolescents in Ghana

Åberg, Carola Höglund; Kwamin, Francis; Claesson, Rolf; Johansson, Anders; Haubek, Dorte

doi:10.1902/jop.2012.110699

Cited by 44 publications

(81 citation statements)

References 51 publications

(90 reference statements)

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“…A total of 500 adolescents (mean age 13.2 years, SD: 1.5) were enrolled in the study undertaken in Ghana in 2009 (9). After 2 years, 397 (79.4%) were recruited for a periodontal re-examination (10).…”

Section: Methodsmentioning

confidence: 99%

“…Twelve of the adolescents (seven girls and five boys) were recruited from one private school, and the remaining 86 were from five public schools. Detailed information on the study population, demographics, and ethics, including signed consents by parents has been reported on previously (9, 10). Knowledge on the socioeconomic status, the medical health status, and the intake of antibiotics within the past 3 months before the examination are available from the studies by Åberg and co-workers (9, 10).…”

Section: Methodsmentioning

confidence: 99%

“…In particular, this association between A. actinomycetemcomitans and periodontitis has been strengthened by studies focusing on the presence of a highly virulent genotype of A. actinomycetemcomitans , named the JP2 clone, expressing a highly leukotoxic activity. A number of studies have strongly associated the JP2 clone with aggressive periodontitis in young individuals of Northern and Western African origin (5–9). Such studies have been carried out in order to understand the high prevalence of aggressive periodontitis in young individuals of these populations and to evaluate the role of the JP2 and non-JP2 genotypes of A. actinomycetemcomitans in the progression of periodontitis.…”

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confidence: 99%

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Subgingival bacteria in Ghanaian adolescents with or without progression of attachment loss

Dahlén

Claesson

Åberg

et al. 2014

Journal of Oral Microbiology

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ObjectiveThis study describes subgingival bacterial profiles associated with clinical periodontal status in Ghanaian adolescents with or without progression of attachment loss.Materials and methodsAmong 500 adolescents included in a cohort study, 397 returned 2 years later for a periodontal re-examination, including full-mouth CAL measurements. At follow-up, a subgroup of 98 adolescents was also subjected to bacterial sampling with paper points at four periodontal sites (mesial aspect of 11, 26, 31, and 46) and analyzed with the checkerboard DNA–DNA hybridization technique against DNA-probes from nine periodontitis-associated bacterial species.ResultsThe 98 Ghanaian adolescents examined in the present study were similar to the entire group examined at the 2-year follow-up with respect to age, gender, and CAL ≥3 mm. A high detection frequency of Fusobacterium nucleatum and Prevotella intermedia (>99%) using checkerboard analysis was found, while for Aggregatibacter actinomycetemcomitans the detection frequency was <50%. A strong correlation was found at the individual level between the presence of P. intermedia and the total CAL change, and P. intermedia and Porphyromonas gingivalis were strongly correlated with a change in CAL and probing pocket depth (PPD) at the sampled sites. In a linear regression model, a significant discriminating factor for the total CAL change in the dentition during the 2-year follow-up period was obtained for P. intermedia and public school.ConclusionThis study indicates that subgingival bacterial species other than A. actinomycetemcomitans, for example, P. intermedia, have a significant association with periodontal breakdown (change in CAL) in Ghanaian adolescents with progression of periodontal attachment loss.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Subgingival bacteria in Ghanaian adolescents with or without progression of attachment loss

Dahlén

Claesson

Åberg

et al. 2014

Journal of Oral Microbiology

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“…The JP2 genotype of A. actinomycetemcomitans is present in endemic form in populations of African origin (25)(26)(27) .…”

Section: Resultsmentioning

confidence: 99%

“…Studies have shown that the high leukotoxicity of the JP2 genotype of Aggregatibacter actinomycetemcomitans has been associated with periodontal attachment loss in Afrodescendants (25)(26)(27) .…”

Section: Background and Justificationmentioning

confidence: 99%

Evaluación del estado periodontal en una población afro-uruguaya residente en Montevideo. Estudio transversal

Rotemberg

Capó

Batlle

et al. 2017

Odontoestomatología

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The diversity approach in health focuses on recognizing and paying special attention to the different interests, demands, needs and health-disease processes specific to certain people. Ethnic-racial considerations in these cases become fundamental.In Uruguay, census data show that 8.1% of the population (approximately 255,000 people) consider themselves Afrodescendants, which makes them the main ethnic-racial minority of the country.To date, there are no surveys on the periodontal condition of Afrodescendant population in our country.Objective: to evaluate the oral and periodontal status of patients through health-disease process indicators.Materials and methods: descriptive, cross-sectional study of the Afro-Uruguayan population. Inclusion criteria: age range from 15 to 35, living in Montevideo. Exclusion criteria: pregnancy, having received periodontal treatment or treatment with antibiotics in the last 6 months. The size of each population sample with or without African origin was of 40 individuals each, half men, half women. The Rediente Clinical History was used, the periodontal parameters were recorded using a periodontal probe calibrated by millimeter, and six sites per tooth were examined in a full mouth.Results: the group of Afrodescendants have one less tooth, on average, than non-Afrodescendants, especially the first mandibular molars. They also show higher prevalence, depth and severity of attachment loss compared to the control group. No statistically significant differences were found in probing depth between the two groups.Conclusions: Afrodescendants became part of the popular sectors of society, which makes them more vulnerable. In the age range considered (15-35), Afrodescendants have higher prevalence, extension and severity of clinical attachment loss than non-Afrodescendants. No statistically significant differences were found in the considered age range regarding probing depth in the populations examined.

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Aggregatibacter

Nørskov‐Lauritsen

2021

Bergey's Manual of Systematics of Archaea and Bacteria

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Ag.gre.ga.ti.bac'ter. L. v. aggregare , to come together, aggregate; N.L. masc. n. bacter , rod; N.L. masc. n. Aggregatibacter rod‐shaped bacterium that aggregates with others. Proteobacteria / Gammaproteobacteria / Pasteurellales / Pasteurellaceae / Aggregatibacter The genus Aggregatibacter was established by reclassification of species previously classified in the genera Actinobacillus and Haemophilus . The genus includes typical members of the family Pateurellaceae with respect to cultural characteristics, phenotype, and colony morphology. Humans are the only documented hosts, although Aggregatibacter ‐like bacteria have been cultured from some higher primates. The genus includes four species with validated names. All species of the genus have been cultured from invasive infections of humans. Separation of Aggregatibacter from all other genera of the family Pasteurellaceae by phenotypic characters can be challenging. Partial sequencing of 16S rRNA genes or partial proteomic analysis by mass spectrometry is credible authenticating procedures. Members of the class Gammaproteobacteria , family Pasteurellaceae . Known habitat is the oral cavity of humans. Average DNA G + C content (mol%) : 42.2–44.4. Type species : Aggregatibacter actinomycetemcomitans Nørskov‐Lauritsen and Kilian 2006 VP .

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Presence of JP2 and Non‐JP2 Genotypes of Aggregatibacter actinomycetemcomitans and Attachment Loss in Adolescents in Ghana

Abstract: A. actinomycetemcomitans and AL were frequently found in Ghanaian adolescents. The school type was the strongest predictor of both presence of A. actinomycetemcomitans and AL.

Cited by 44 publications

References 51 publications

Subgingival bacteria in Ghanaian adolescents with or without progression of attachment loss

Subgingival bacteria in Ghanaian adolescents with or without progression of attachment loss

Evaluación del estado periodontal en una población afro-uruguaya residente en Montevideo. Estudio transversal

Aggregatibacter

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