Presence of impaired intestinal calcium absorption in chronic hypovitaminosis D and its change after cholecalciferol supplementation: assessment by the calcium load test

Gupta, Amit; Gupta, Nidhi; Singh, Namrata; Goswami, Ravinder

doi:10.1111/j.1365-277x.2009.01003.x

Cited by 5 publications

(2 citation statements)

References 30 publications

(64 reference statements)

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“…Moreover, 24 h urine creatinine should not vary too much between two measurements. As already mentioned, chronic vitamin D deficiency promote secondary HPT and can also impair the intestinal calcium absorption required for test interpretation [45][46][47]. It appears that even long-term vitamin D supplementation (100.000 IU/week for minimum 4 month) was not enough to replete every patient (n = 7).…”

Section: Causes Of Test Failurementioning

confidence: 99%

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How useful is an oral calcium load test for diagnosing recurrent calcium stone formers?

et al. 2022

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Hypercalciuria is the main risk factor for recurrent calcium urolithiasis. The goal of our study is to determinate how useful an oral calcium load test is for stone formers to classify different forms of hypercalciuria in pathogenetic categories defined as renal or absorptive according to the current knowledge. Between June 2013 and February 2016, a prospective study was carried out on 117 documented recurrent hypercalciuric stone formers undergoing an oral calcium load test modified from the original description by Pak. After 2 days of calcium-restricted diet, urine and blood were analyzed at baseline and 120 min after receiving orally 1 g of calcium. Total and ionized calcium, parathyroid hormone from serum and urine calcium and creatinine were assessed in order to divide patients in three groups as previously described: resorptive, absorptive, and renal hypercalciuria. This allowed the identification of 19, 39, 34 and 33 patients with normocalcemic primary hyperparathyroidism (NPHPT), renal hypercalciuria aka renal calcium leak (RCL), absorptive hypercalciuria (AH) and unidentified cause, respectively. Patients with NPHPT (who required parathyroidectomy) experienced a lower PTH decrease (41.41 ± 12.82 vs. 54.06 ± 13.84% p < 0.01), higher beta-crosslaps, as well as lower TmP/GFR and distal third radius bone mineral density. RCL resulted in increased fasting urine calcium-to-creatinine ratio (Uca/Cr), i.e., > 0.37 mmol/mmol), without hyperparathyroidism. AH was diagnosed by the presence of ΔUCa/Cr > 0.60 mmol/mmol between baseline and 120 min without any other anomaly. For all remaining patients, results were inconclusive due to the lack of sufficient increase in serum calcium or because the cause of lithogenesis could not be clearly identified. The oral calcium load test is useful in nearly 80% of patients by identifying the different forms of hypercalciuria causing urolithiasis and by guiding treatment, including parathyroid surgery.

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Section: Causes Of Test Failurementioning

confidence: 99%

“…Samples are taken within the two hours following calcium intake (vs 4 h in the original "Pak" test). In the literature, up to 2 weeks of calcium restricted diet were recommended [46] or on the contrary others consider 8 h fasting during the night enough to interpret morning calciuria [35].…”

Section: Causes Of Test Failurementioning

confidence: 99%

How useful is an oral calcium load test for diagnosing recurrent calcium stone formers?

et al. 2022

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Vitamin D supplementation for prevention of mortality in adults

Bjelaković¹,

Gluud²,

Nikolova³

et al. 2011

Cochrane Database of Systematic Reviews

189

126

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Vitamin D supplementation for prevention of mortality in adults

Bjelaković

Gluud

Nikolova

et al. 2014

Cochrane Database of Systematic Reviews

442

346

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Vitamin D3 seemed to decrease mortality in elderly people living independently or in institutional care. Vitamin D2, alfacalcidol and calcitriol had no statistically significant beneficial effects on mortality. Vitamin D3 combined with calcium increased nephrolithiasis. Both alfacalcidol and calcitriol increased hypercalcaemia. Because of risks of attrition bias originating from substantial dropout of participants and of outcome reporting bias due to a number of trials not reporting on mortality, as well as a number of other weaknesses in our evidence, further placebo-controlled randomised trials seem warranted.

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Presence of impaired intestinal calcium absorption in chronic hypovitaminosis D and its change after cholecalciferol supplementation: assessment by the calcium load test

Cited by 5 publications

References 30 publications

How useful is an oral calcium load test for diagnosing recurrent calcium stone formers?

How useful is an oral calcium load test for diagnosing recurrent calcium stone formers?

Vitamin D supplementation for prevention of mortality in adults

Vitamin D supplementation for prevention of mortality in adults

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