Presence of Helicobacter pylori and Campylobacter ureolyticus in the oral cavity of a Northern Thailand population that experiences stomach pain

Abstract

Objective: To investigate oral diseases and microbiological conditions, such as the presence of ureolytic bacteria in dental plaque, in relation to experience of stomach pain in a remote adult Asian population.Methods: Ninety-three adults, 40–60-years old, from the Karen Hill tribe in Northern Thailand with no regular access to dental care were examined. Clinical registrations were performed and interproximal gingival plaque samples were collected and analyzed with the checkerboard (CKB) method for the presence of 14 oral bacterial species.Results: A number of 61 subjects reported daily stomach pain while 32 subjects had no symptoms from the stomach. The subjects with stomach pain had fewer remaining teeth (p < 0.05), higher caries experience (p < 0.05) and less BoP (p < 0.01). Most of the bacterial species were clustered statistically in three factors in a factor analysis, which together explained 65% of the microbiological variance. Factor 1, explaining 43.0% of the variance, was statistically associated with stomach pain (p < 0.001).Conclusions: The interproximal plaque/biofilm in adults of the study population showed a common presence of two gastrointestinal pathogens H. pylori and C. ureolyticus. The study also indicates for the first time a potential association between C. ureolyticus and stomach pain.

The neovaginal microbiome of transgender women post-gender reassignment surgery

“…Oralgenital contact has been suggested as a possible route of transmission of these bacteria to the genital tract [16]. Anaeroglobus geminatusa, Pseudoramibacter alactolyticus, Campylobacter ureolyticus, Fusobacterium nucleatum, and Actinomyces have been described as putative pathogens also found in the oral cavity associated with periodontitis and endodontic infections [17][18][19][20][21]. The presence of oral bacteria in the neovaginal compartment could suggest oral-genital bacterial transmission.…”

Cardiac Tamponade Caused by Campylobacter ureolyticus Purulent Effusion

“…Similar studies echo the theme that C. ureolyticus may be more prevalent than previously thought throughout the world. Increasing incidence, though may be related to improved culture and molecular techniques [11][12][13][14][15].…”

How Do Polymer Coatings Affect the Growth and Bacterial Population of a Biofilm Formed by Total Human Salivary Bacteria?—A Study by 16S-RNA Sequencing

“…[9,10] Brevundimonas diminuta Gram− aerobe periodontal pathogen, in subgingival niche [37] Campylobacter consisus Gram− anaerobe in subgingival niche, isolated from the oral cavity of patients with gingivitis and periodontitis, but with no clear association to either disease or other human oral inflammatory diseases [38] Campylobacter curvus Gram− anaerobe subgingival; no significant evidence for causing periodontal disease, but found it higher proportions at periodontitis sites as compared to healthy ones [39] Campylobacter ureolyticus Gram− anaerobe gastrointestinal pathogen; present in subgingival plaque; associated with poor oral hygiene. [40] Corynebacterium Gram+ aerobe, facultative anaerobe found in dental plaque, associated with the formation of dental calculi [41] Dialister Gram− anaerobe D. pneumosintes and D. invisus are periodontal pathogens, have been associated with refractory periodontitis, acute necrotizing ulcerative gingivitis, endodontic infections; subgingival [37,42] Enterococcus Gram+ anaerobe E. faecalis has been related to caries, endodontic infections, periodontitis, and peri-implantitis, biofilm former able to integrate in the oral biofilm in situ [43] Filifactor alocis Gram+ anaerobe associated with periodontitis. [9,10] Fusobacterium nucleatum Gram− anaerobe member of the "orange complex", periodontal pathogen, involved in primary infections of endodontal lesions, associated with subgingival plaque, peri-implantitis, gingivitis, advanced irreversible forms of periodontitis, associated with dental fluorosis, bridging microorganism which can co-aggregate with early and late colonizers, plays a major role in the maturation of the oral biofilm, one of the most abundant genera in the native biofilm [12,13,[44][45][46]…”

“…Staphylococcus schleiferi Gram+ facultative anaerobe veterinary pathogen, but can also cause opportunistic infections in humans [58] Streptococcus koreensis Gram+ facultative anaerobe associated with subgingival dental plaque/periododitis lesion [58] Streptococcus parasanguinis Gram+ facultative anaerobe "pioneer species", colonizes teeth fast; involved in the periodontal biofilm, periodontal pathogen; dynamic interaction with A. actinomycetemcomitans, a late colonizer and periodontal pathogen; together with A. actinomcetemcomitans and Filifactor alocis: may be biomarker for periodontitis [40,45,59] Streptococcus pneumoniae Gram+ facultative anaerobe associated with periodontal health; associated with sinusitis [60] Streptococcus salivarius Gram+ facultative anaerobe colonizes the tongue associated with carious lesions [45,49] Streptococcus sanguinis Gram+ facultative anaerobe "pioneer species", colonizes teeth fast; important for supragingival biofilm formation; may suppress the generation of caries; antagonism between S. sanguinis and S. mutans; associated with oral health [37,61] Streptococcus thermophilus Gram+ facultative anaerobe poor biofilm former [32] Tannerella forsythia Gram− anaerobe member of the "red complex"; in subgingival niche; associated with periodontal disease and peri-implantitis [4,5,9,10,12,13,62] Tannerella sp. Oral taxon HOT-286 Gram− anaerobe associated with periodontal health; in subgingival niche; may provide protection from acquisition of T. forsythia [62] Veillonella Gram− anaerobe found on the tongue, the buccal mucosa, and in saliva, interactions between Streptococcus species and Veillonella species in the early stages of oral biofilm formation; associated with caries, consistently resistant to antibiotics in periodontal patients undergoing therapy; presence in children may predict the development of future caries, indication for poor oral health.…”