Presence of human papillomavirus in semen of healthy men is firmly associated with HPV infections of the penile epithelium

Luttmer, Roosmarijn; Dijkstra, Maaike G.; Snijders, Peter J.F.; Jordanova, Ekaterina S.; King, Audrey J.; Pronk, Divera T.M.; Garolla, Andrea; Hompes, Peter G.A.; Berkhof, Johannes; Bleeker, Maaike; Doorbar, John; Heideman, Daniëlle A.M.; Meijer, Chris J.L.M.

doi:10.1016/j.fertnstert.2015.06.028

Cited by 22 publications

(26 citation statements)

References 37 publications

(46 reference statements)

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“…Human papillomavirus DNA in semen might originate from a male genital tract reservoir or could be a result of contamination of HPV from the skin/mucosa during ejaculation. In agreement with the results of Golob et al () and Luttmer et al (), the control group in this study showed a high prevalence of HPV DNA on genital skin swabs and in semen, and the concordance of HPV genotypes detected in the two locations was high.…”

Section: Discussionsupporting

confidence: 93%

“…In a Danish study, we detected HPV in the spermatozoa from 16% of human sperm donors, and in 2/3 (10.6%), high‐risk types of HPV were detected (Kaspersen et al, ). Studies have suggested that seminal HPV originates from urogenital tract reservoirs (Damke et al, ) or from genital skin or mucosa (Giovannelli et al, ; Golob et al, ; Luttmer et al, ). Possible seminal “HPV contamination” from the genital skin and mucosa is supported by near associations between HPV types detected in the semen and on genital skin (Golob et al, ; Luttmer et al, ).…”

Section: Introductionmentioning

confidence: 99%

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Seminal human papillomavirus originates from the body surface and is not a frequent aetiological factor in azoospermia

et al. 2018

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Human papillomavirus (HPV) DNA has been detected in the testis tissue of 6.5% of 185 men with non‐obstructive azoospermia (NOA). Others have suggested that seminal HPV originates from contamination from the genital skin and mucosa. One hundred unselected azoospermic men and 43 normal men undergoing vasectomy were recruited. Testicular biopsies for HPV examination were collected from all the men. Additionally, the normal men undergoing vasectomy delivered a semen sample and had a swab for HPV examination taken from the genital skin before vasectomy. A piece of each Vas deferens obtained during the vasectomy was examined for the presence of HPV. Two of the primarily azoospermic men were shown to have cryptozoospermia. It was not possible to detect HPV in the testis tissue of any of the included 98 azoospermic men or the 43 proven fertile men. In the proven fertile men, HPV DNA was detected in the semen of 15 men (35%), on the genital skin of 28 men (65%), and in the Vas deferens in three cases (7%). In 13 (87%) men with HPV‐positive semen samples, HPV DNA was also detected in the skin swabs, and in 11 men (73%), identical HPV genotypes were found in the two locations.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Seminal human papillomavirus originates from the body surface and is not a frequent aetiological factor in azoospermia

et al. 2018

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“…Luttmer et al studying Human Papilloma virus (HPV) have found a high prevalence of this virus in semen – 27.2% of healthy adults in Amsterdam – and using fluorescence in situ hybridization (FISH) for HPV-DNA and immunocytochemistry for the HPV-L1 and HPV-E4 proteins, the authors detected HPV-DNA, HPV-E4 and HPV-L1 in exfoliated keratinocytes present in some HPV16-positive semen samples, indicating the presence of HPV viral particles [28].…”

Section: Discussionmentioning

confidence: 99%

Prolonged shedding of Chikungunya virus in semen and urine: A new perspective for diagnosis and implications for transmission

Bandeira

Campos

Rocha³

et al. 2016

IDCases

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AbsractWe report the presence of Chikungunya (CHIKV) RNA in the blood, urine and semen during the acute phase of the disease in an adult with a dual infection with Dengue virus type 3. The patient, a 25 yr-old man from Salvador, Brazil, reported a 6-day duration of high fever, arthralgia, myalgia, headache and photophobia.Blood and semen specimens were positive for CHIKV in the first collected samples; semen and urine specimens were positive for CHIKV after 30 days of symptoms onset. DENV-3 RNA was positive in blood specimen when first collected 6 days after the initiation of symptoms.We describe for the first time the presence of CHIKV RNA in urine and semen for an extended period of time and we address the possible implications of these findings for diagnosis and transmission dynamics.

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“…Covariates were derived from a risk factor questionnaire that was administered at each visit, which was described and validated previously [34,86,69,91,23,1]. Questions covered sociodemographic characteristics, sexual behaviors, sex partnerships, and condom use.…”

Section: Details Of the Hpv In Men Data And Selection Of Covariate Vamentioning

confidence: 99%

“…Covariates were selected for inclusion in the model based on known risk factors identified in the literature for HPV in men [34,33,35,37,83,84,85,94,44,91,23,69,1]. We also included country of residence as a covariate.…”

Section: Details Of the Hpv In Men Data And Selection Of Covariate Vamentioning

confidence: 99%

Recurring infection with ecologically distinct human papillomavirus (HPV) types explains high prevalence and diversity

Ranjeva¹,

Eb²,

Dukić

et al. 2017

Preprint

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The high prevalence of human papillomavirus (HPV), the most common sexually transmitted infection, arises from the coexistence of over 200 genetically distinct types. Accurately predicting the impact of vaccines that target multiple types requires understanding the factors that determine HPV diversity. The diversity of many pathogens is driven by type-specific or "homologous" immunity, which promotes the spread of variants to which hosts have little immunity. To test for homologous immunity and to identify mechanisms determining HPV transmission, we fitted nonlinear mechanistic models to longitudinal data on genital infections in unvaccinated men. Our results provide no evidence for homologous immunity, instead showing that infection with one HPV type strongly increases the risk of infection with that type for years afterwards. For HPV16, the type responsible for most HPV-related cancers, an initial infection increases the one-year probability of reinfection by 20-fold, and the probability of reinfection remains 14-fold higher two years later. This increased risk occurs in both sexually active and celibate men, suggesting that it arises from auto-inoculation, episodic reactivation of latent virus, or both. Overall our results show that high HPV prevalence and diversity can be explained by a combination of a lack of homologous immunity, frequent reinfections, weak competition between types, and variation in type fitness between host subpopulations. Due to the high risk of reinfection, vaccinating boys that have not yet been exposed may be crucial to reduce prevalence, but our results suggest that there may also be large benefits from vaccinating previously infected individuals.

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Presence of human papillomavirus in semen of healthy men is firmly associated with HPV infections of the penile epithelium

Abstract: HPV-DNA presence in semen of healthy men is common and associated with HPV infections of the penile epithelium. HPV-DNA presence in semen may result from desquamation of HPV-infected penile cells.

Cited by 22 publications

References 37 publications

Seminal human papillomavirus originates from the body surface and is not a frequent aetiological factor in azoospermia

Seminal human papillomavirus originates from the body surface and is not a frequent aetiological factor in azoospermia

Prolonged shedding of Chikungunya virus in semen and urine: A new perspective for diagnosis and implications for transmission

Recurring infection with ecologically distinct human papillomavirus (HPV) types explains high prevalence and diversity

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