Presence of high contents of thymus and activation-regulated chemokine in platelets and elevated plasma levels of thymus and activation-regulated chemokine and macrophage-derived chemokine in patients with atopic dermatitis

Fujisawa, Takao; Fujisawa, Ryuichi; Kato, Yoshiko; Nakayama, Takashi; Morita, Atsushi; Katsumata, Hajime; Nishimori, Hisashi; Iguchi, Kosei; Kamiya, Hitoshi; Gray, Patrick W.; Chantry, David; Suzuki, Ryuji; Yoshie, Osamu

doi:10.1067/mai.2002.126079

Cited by 150 publications

(156 citation statements)

References 34 publications

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“…Nasal epithelial cells derived from allergic individuals released larger amount of TARC than those derived from normal subjects [26]. Elevated levels of TARC [21] and MDC [21,27] were also found in the serum of atopic dermatitis (AD) patients compared with controls. In addition, serum TARC and MDC levels correlated with the clinical and laboratory markers for AD severity [17,21,28].…”

Section: Discussionmentioning

confidence: 91%

Plasma TARC concentration may be a useful marker for asthmatic exacerbation in children

Leung¹,

Wong²,

Lam³

et al. 2003

Eur Respir J

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Recent studies suggested the T-helper cells type-2 lymphocytes-specific thymus and activation-regulated chemokine (TARC) and monocyte-derived chemokine (MDC) are useful inflammatory markers for chronic asthma. However, their roles in assessing the severity of acute asthma are unknown. This study aims to evaluate the serial changes of plasma TARC and MDC concentrations in children with asthmatic exacerbation.All patients with acute asthma were treated with systemic corticosteroid for 5 days. The severity of asthmatic exacerbation was classified according to the Global Initiative for Asthma guidelines. Plasma TARC and MDC concentrations were measured by sandwich enzyme immunoassays.Sixteen children, with a median (interquartile range) age of 9.3 (7.2-10.6) yrs and asthmatic exacerbation, were recruited. Plasma TARC concentration showed inverse correlation with peak expiratory flow rate at presentation. The median plasma TARC concentration was highest during the acute attacks (46 pg?mL -1 ) as compared to those levels at 1 (31 pg?mL -1 ) and 5 weeks (32 pg?mL -1 ) following treatment. The median plasma MDC level similarly decreased from 698 pg?mL -1 at baseline to 261 pg?mL -1 1 week later, but increased back to 574 pg?mL -1 at 5 weeks. These results suggest that plasma T-helper cells type-2 lymphocytes-specific thymus and activation-regulated chemokine but not monocyte-derived chemokine concentration may be a useful inflammatory marker in assessing asthmatic exacerbation in children. Eur Respir J 2003; 21: 616-620.

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Section: Discussionmentioning

confidence: 91%

Plasma TARC concentration may be a useful marker for asthmatic exacerbation in children

Leung¹,

Wong²,

Lam³

et al. 2003

Eur Respir J

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“…For example, platelets have been reported to be a major source of CCL17. 20 During the clotting process, activated platelets release high concentrations of CCL17 in an autocrine manner, which could further enhance platelet aggregation. 20, 21 AP-1 (Fos/Jun) is a transcriptional regulator comprising members of the Fos and Jun families of DNA-binding 100-fold competitor probe was added ( Figure S2, Lanes 5-8), whereas excess unlabeled allele C probe did not compete with the labeled allele T probe ( Figure S2, Lanes 9-12).…”

Section: Effects Of Ccl17 Snp Rs223828 On Ccl17 Promoter Activitymentioning

confidence: 99%

Association Between a <i>CCL17</i> Genetic Variant and Risk of Coronary Artery Disease in a Chinese Han Population

Yang

Long

et al. 2018

Circ J

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Background:In the present study we investigated the effects of genetic variations in the C-C motif chemokine ligand 17 (CCL17) gene on serum CCL17 levels and risk of coronary artery disease (CAD). Methods and Results:A case-control study was conducted to determine causal inferences among CCL17 single-nucleotide polymorphisms (SNPs), serum CCL17 levels, and risk of CAD. Luciferase assays, electrophoretic mobility shift assays (EMSA), and allele-specific quantitative chromatin immunoprecipitation (ChIP) assays were used to assess the function of the SNPs. In all, 947 participants (794 with CAD, 153 without CAD) were included in the study. The T allele in rs223828, located in intron of the CCL17 gene, was associated with increased serum CCL17 levels as well as increased CAD risk. A causal inference test using mediation analysis suggested that rs223828 had a significant indirect casual effect on the increased risk of CAD mediated via serum CCL17 levels. Luciferase assays confirmed that the rs223828T allele enhances CCL17 promoter activity. Protein-DNA binding studies using EMSA and allele-specific quantitative ChIP assays indicated preferential activator protein-1 (AP-1) complex formation and recruitment with the rs223828 T allele compared with the C allele. Conclusions:We propose that the CCL17 SNP rs223828 is associated with increased risk of CAD, and that this site may be a potential AP-1 binding site.

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“…The chemokine receptors are expressed on the surface of several cell types involved in the allergic inflammation, e. g. eosinophils, monocytes, Th1 and Th2 lymphocytes (22). Atopic dermatitis is associated with high circulating levels of Th2-associated eotaxin (CC ligand 11 (CCL11) (16), macrophage-derived chemokine (MDC (CCL22)) (15,16,23), thymus-and activation-regulated chemokine (TARC (CCL17)) (15)(16)(17) and pulmonary and activation regulated chemokine (PARC (CCL18) (24) in children and adults. Increased levels of MDC (CCL22) and TARC (CCL17) in bronchoalveolar lavage fluid (BALF) have been reported in asthmatics (18) after allergen challenge (20).…”

Section: Introductionmentioning

confidence: 99%

“…In addition to the Th2-dominated cytokine profile, an upregulation of Th2-induced chemokines has been associated with allergic manifestations including atopic dermatitis (15)(16)(17) and asthma (18)(19)(20). The chemokines comprise a large protein family, which is responsible for the trafficking of leukocytes to the site of inflammation and the regulation of leukocyte maturation (21).…”

Section: Introductionmentioning

confidence: 99%

Cord blood cytokines and chemokines and development of allergic disease

Sandberg

Frykman

Ernerudh

et al. 2009

Pediatric Allergy Immunology

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Exposure to ubiquitous allergens early in life, even before birth, may influence the incidence of allergic diseases later in life. During pregnancy, the fetomaternal interface is surrounded by high levels of T-helper (Th)2-like cytokines, possibly favouring the development of Th2-like immune responses in the offspring. The aim of this study was to evaluate the relation between cord blood (CB) IgE antibodies, Th1- and Th2-like cytokines and chemokines, maternal allergy and development of allergic disease during the first 2 yr of life in the offspring. The CB cytokine and chemokine levels from children of 20 allergic and 36 non-allergic women were determined by a multiplexed Luminex assay and ELISA. Total CB and maternal IgE antibody concentrations were quantified using ImmunoCAP technology. The maternal IgE levels during and after pregnancy correlated with CB IgE and Th2-associated macrophage-derived chemokine [MDC (CCL22)] levels. Development of allergic disease and sensitization was associated with increased CB IgE and MDC (CCL22) levels, as well as high ratios of MDC (CCL22) to Th1-associated interferon-gamma inducible protein 10 [IP-10 (CXCL10)] and interferon-gamma inducible T-cell alpha-chemoattractant [I-TAC (CXCL11) (n = 7 allergic vs. n = 25 non-allergic)]. The correlations between maternal IgE and CB IgE and MDC (CCL22) levels possibly indicate that the maternal immunity can affect the Th1/Th2 profile in the neonate. Development of allergic disease is associated with a more marked Th2-like deviation already at birth, shown as increased levels of CB IgE and MDC (CCL22) and higher ratios of MDC (CCL22) to IP-10 (CXCL10) and I-TAC (CXCL11).

This is the pre-reviewed version of the following article: Martina Sandberg, Anne Frykman, Jan Ernerudh, Göran Berg, Leif Matthiesen, Christina Ekerfelt, Lennart Nilsson and Maria Jenmalm, Cord blood cytokines and chemokines and development of allergic disease, 2009, PEDIATRIC ALLERGY AND IMMUNOLOGY, (20), 6, 519-527. which has been published in final form at: http://dx.doi.org/10.1111/j.1399-3038.2008.00794.x Copyright: Blackwell Publishing Ltd http://www.blackwellpublishing.com/

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Presence of high contents of thymus and activation-regulated chemokine in platelets and elevated plasma levels of thymus and activation-regulated chemokine and macrophage-derived chemokine in patients with atopic dermatitis

Cited by 150 publications

References 34 publications

Plasma TARC concentration may be a useful marker for asthmatic exacerbation in children

Plasma TARC concentration may be a useful marker for asthmatic exacerbation in children

Association Between a <i>CCL17</i> Genetic Variant and Risk of Coronary Artery Disease in a Chinese Han Population

Cord blood cytokines and chemokines and development of allergic disease

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