Presence of glucagon-(1–21)-like immunoreactive substance in the dog small intestinal mucosa

Itoh, H.; Namba, Mitsuyoshi; Watanabe, Nobuaki; Ohara, Toshiko; Matsuyama, Tatsuo; Komatsu, Ryoya; Shinomura, Yasuhisa; Kôno, Norio; Tarui, Seiichiro

doi:10.1016/0006-291x(89)92703-4

Cited by 1 publication

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“…Reports of a trophic effect of GI-21 on rat intestinal cells in vitro (Watanabe, Matsuyama, Namba, Miyagawa, Itoh, Komatsu, Kono & Tarui, 1988 b) and in vivo (Watanabe et al 1988a) has led to the suggestion that the N-terminal amino acid sequence plays an important role in the control of intestinal growth. G -21-like immunoreactivity is widely distributed throughout the small intestine and colon, and closely follows the distribution of glucagon-like immunoreactivity (Itoh, Namba, Watanabe, Ohara, Matsuyama, Komatsu, Shinomura, Kono & Tarui, 1989).…”

Section: Introductionmentioning

confidence: 65%

Glucagon 1‐21 reduces intestinal epithelial cell proliferation in parenterally fed rats

Goodlad

Ghatei²,

Bloom³

et al. 1991

Experimental Physiology

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SUMMARYThe hypothesis that glucagon 1-21 (GI-21) is trophic to the gastrointestinal tract was investigated in the hypoplastic intestine of intravenously maintained rats. Three groups of eight rats were fed parenterally for three days and then were infused with either 0, 20 or 80,ug rat-1 day-1 of G1-21 for 3 days. No significant effect on the weight of the stomach, caecum or colon was observed, but both the weight and crypt cell production rate of the small intestine were significantly decreased by G1-21. Plasma enteroglucagon was also decreased by GI-21 treatment. It is concluded that GI-21 does not have a trophic effect on the gastrointestinal tract, and, in fact, has an antiproliferative effect on the small intestine, which could in turn be modulated by decreased levels of endogenous enteroglucagon.

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Section: Introductionmentioning

confidence: 65%