Presence of enthesopathy demonstrated with ultrasonography in systemic sclerosis

Kılıç, Erdem; Kılıç, Gamze; Akgül, Özgür; Özgöçmen, Salih

doi:10.3109/14397595.2015.1019962

Cited by 12 publications

(13 citation statements)

References 36 publications

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“…Articular involvement is a common feature of SSc and it is frequently underestimated [4,5]. In SSc, synovitis is the most common joint manifestation, but specific SpA-like alterations have also been described [8,10]. In this context, our data definitively confirm that enthesis alterations are common in SSc, affecting both upper and lower limbs.…”

Section: Discussionsupporting

confidence: 76%

“…In particular, tenosynovitis of the hand was found in 27% of SSc patients, showing a mixed pattern of inflammatory and fibrotic changes [6]. In addition, other studies suggested that even knee and ankle tendons without sheath are altered in SSc patients [9] and that enthesopathy is more frequent in SSc patients than in healthy subjects [10]. Collectively, the bulk of data suggest that there are SpA-like articular manifestations in SSc, but only one study focussed on the prevalence of entheseal alterations in SSc patients and none on the pathologic alterations of the synovio-entheseal complex (SEC) in this disease.…”

Section: Introductionmentioning

confidence: 99%

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Enthesopathy and involvement of synovio-entheseal complex in systemic sclerosis: an ultrasound pilot study

et al. 2019

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Objectives SSc is a chronic autoimmune disease characterized by inflammation of the skin and multiple internal organs. Articular involvement is one of the main features of SSc, and typical hallmarks of SpA have been found in SSc patients. The aim of the present study was to estimate the prevalence of entheseal and synovio-entheseal complex (SEC) alterations in a cohort of SSc patients. Methods One hundred SSc patients and 25 healthy subjects were included in this cross-sectional study. The enthesis sites of lateral epicondylar common extensor tendons (CET) and the enthesis of the Glasgow Ultrasound Enthesis Scoring System were evaluated. SEC involvement was evaluated only at CET enthesis. Results In SSc, the Glasgow Ultrasound Enthesis Scoring System score was significantly higher (median 4.0, interquartile range 2.0–7.0) than in controls (median 1.0, interquartile range 0.0–3.0) (P < 0.0001). CET enthesis of SSc patients showed more frequent US B-mode alterations than that of controls (χ2 = 11.47, P = 0.0007 for size; χ2 = 13.79, P = 0.0002 for cortical irregularity, χ2 = 5.24, P = 0.022 for calcification/enthesophytes). Power Doppler US signal at CET enthesis was significantly more frequent in SSc patients than in healthy controls (χ2 = 9.11, P = 0.0025), as was the concomitant SEC involvement (χ2 = 8.52, P = 0.0035). Conclusion These data show that SSc patients frequently present US features of enthesopathy. Moreover, CET enthesopathy was correlated with SEC inflammation, suggesting that entheseal inflammation in SSc may share the same micro-anatomical targets as found in SpA.

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Enthesopathy and involvement of synovio-entheseal complex in systemic sclerosis: an ultrasound pilot study

et al. 2019

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“…Patients with SSc, especially those with the dcSSc, may have joint involvement (Avouac et al, 2010) and present enthesopathy (Kilic, Kilic, Akgul, & Ozgocmen, 2015). Proximal muscle weakness in the shoulder and hip-pelvic region is a common feature (Akesson, Fiori, Krieg, van den Hoogen, & Seibold, 2003;Clements et al, 1978).…”

mentioning

confidence: 99%

Aerobic and resistance exercise in systemic sclerosis: State of the art

Oliveira

Portes

Pettersson

et al. 2017

Musculoskeletal Care

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Patients with SSc without pulmonary involvement can be recommended to be as physically active as the general population. Patients with mild pulmonary involvement can be recommended to be physically active by engaging in exercises of moderate intensity and to participate in moderate-load resistance exercises. Health professionals should inform patients with SSc about the importance of physical activity and avoidance of a sedentary lifestyle.

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“…Kilic et al 25 conducted a cross-sectional single-centre study aimed to investigate the presence and distribution of enthesopathy in SSc. Patients with SSc had significantly higher Madrid sonographic enthesitis index (MASEI) scores than the healthy controls.…”

Section: Enthesitismentioning

confidence: 99%

“…There was a positive correlation between MASEI score and age, modified Rodnan skin score (mRSS) and severity of dyspnoea and a negative correlation with handgrip strength. 25 Terenzi et al 26 conducted a cross-sectional study which sought to estimate the prevalence of entheseal and synovio-entheseal complex (SEC) alterations in SSc. Glasgow Ultrasound Enthesis Scoring System (GUESS) was significantly higher in patients than in healthy controls, including lateral epicondylar common extensor tendon (CET) enthesis.…”

Section: Mskmentioning

confidence: 99%

The role of ultrasound in systemic sclerosis: On the cutting edge to foster clinical and research advancement

Hughes

Bruni

Cuomo³

et al. 2020

Journal of Scleroderma and Related Disorders

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Ultrasound has been widely explored in systemic sclerosis in the clinical and research settings. Ultrasound allows a non-invasive and ionising radiation-free ‘window’ into this complex disease and is well-suited to repeated examinations. Ultrasound provides novel insights into the pathogenesis and measurement of disease in systemic sclerosis, including early (preclinical) internal organ involvement. The purpose of this review is to describe the role of ultrasound to foster clinical and research advancements in systemic sclerosis relating to (1) musculoskeletal, (2) digital ulcer, (3) lung disease and (4) skin disease. We also highlight unmet needs which much be addressed for ultrasound to assume a central role in systemic sclerosis clinical care and research.

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Presence of enthesopathy demonstrated with ultrasonography in systemic sclerosis

Abstract: To the best of our knowledge, this is the first study showing the presence of enthesopathy in patients with SSc using US. Enthesopathy should be kept in mind in symptomatic patients with SSc; additionally, it can be easily identified with US.

Cited by 12 publications

References 36 publications

Enthesopathy and involvement of synovio-entheseal complex in systemic sclerosis: an ultrasound pilot study

Enthesopathy and involvement of synovio-entheseal complex in systemic sclerosis: an ultrasound pilot study

Aerobic and resistance exercise in systemic sclerosis: State of the art

The role of ultrasound in systemic sclerosis: On the cutting edge to foster clinical and research advancement

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