Presence of ear lobe crease may predict intermediate and high-risk patients with acute non-ST elevation acute coronary syndrome

Kahyaoğlu, Muzaffer; Geçmen, Çetin; Candan, Özkan; Gücün, Murat; Karaduman, Ahmet; Güner, Ahmet; Çakmak, Ender Özgün; Bayam, Emrah; Yılmaz, Yusuf; Çelık, Mehmet; İzgi, İbrahim Akın

doi:10.34172/jcvtr.2020.30

Cited by 10 publications

(8 citation statements)

References 35 publications

(38 reference statements)

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“…An association between ELC and coronary atherosclerosis has been identified in clinical [1][2][3][11][12][13] and necropsy [14][15][16] studies. A previous meta-analysis [12] has revealed a potential association between ELC and the presence of coronary artery disease, with an odds ratio of 3.3.…”

Section: Earlobe Creases and The Severity Of Coronary Atherosclerosismentioning

confidence: 99%

Earlobe Creases as a Marker of the Risk for Coronary Atherosclerosis Before Angiography in Elderly and Non-elderly Patients

Sasaki¹,

Nishioka²,

Sasaki³

2023

Cureus

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BackgroundThe close relationship between earlobe creases (ELC) and the presence of coronary artery disease (CAD) has been reported. In addition, this study aimed to determine associations between ELC and the presence, extent, and severity of coronary atherosclerosis assessed by coronary angiography in non-elderly and elderly patients. MethodsWe assessed 1,086 consecutive patients with suspected CAD by coronary angiography. We defined severe CAD as Gensini scores > 20. Multiple logistic regression analysis was adjusted for age, sex, hypertension, diabetes mellitus, smoking status, lipid profiles, and body mass index (BMI) to assess the presence or absence of CAD, multivessel disease, and severe CAD in elderly (age ≥ 60 years) and non-elderly (age < 60 years) patients. ResultsELC was a significantly positive determinant of CAD (odds ratio (OR) = 3.074, p < 0.001), multivessel disease (OR = 3.101, p < 0.001), and severe CAD (OR = 2.823, p < 0.001) in all patients. ELC was also a predictor of CAD, multivessel disease, and severe CAD not only in patients aged ≥ 60 years (OR = 3.095, p < 0.001; OR = 3.071, p < 0.001; OR = 2.761, p < 0.001, respectively) but also in those aged < 60 years (OR = 2.749, p = 0.035; OR = 2.634, p = 0.038; OR = 2.766, p = 0.006, respectively). ConclusionsELC was independently associated with the presence of CAD, multivessel disease, and severe CAD in both elderly and non-elderly patients who were assessed by coronary angiography.

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Section: Earlobe Creases and The Severity Of Coronary Atherosclerosismentioning

confidence: 99%

Earlobe Creases as a Marker of the Risk for Coronary Atherosclerosis Before Angiography in Elderly and Non-elderly Patients

Sasaki¹,

Nishioka²,

Sasaki³

2023

Cureus

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“…50% stenosis on CCTA and showed that ELC was independently associated with MVD even after adjusting for the age, sex, symptoms, and other conventional coronary risk factors (odds ratio =1.9, P=0.010) (3). Kahyaoglu et al performed a retrospective study of 360 patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) and found that patients with ELC had a significantly higher Gensini score than those without ELC (32 vs. 16, P<0.001) (9).…”

Section: Discussionmentioning

confidence: 99%

Relationship between Earlobe Crease and Anatomical Severity of Coronary Artery Disease in ST-segment Elevation Myocardial Infarction

Kaichi,

Kawakami,

Tahara

et al. 2024

Intern. Med.

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Objective Earlobe crease (ELC) is an easily detectable physical sign of cardiovascular risk and coronary artery disease (CAD). However, the relationship between ELC and CAD severity in patients with ST-segment elevation myocardial infarction (STEMI) requiring urgent clinical judgment is unknown. Using the residual synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score, we investigated the relationship between ELC and anatomical severity of CAD. Methods, patients or materials We studied 219 consecutive patients with STEMI (median age, 71 years old) and divided them into 2 groups according to the presence of ELC (ELC group, n=161; non-ELC group, n=58). ResultsThe ELC group had a significantly higher number of diseased vessels than the non-ELC group (! 2 diseased vessels, 79% vs. 46%; ! 3 diseased vessels, 35% vs. 12%; P<0.001). In addition, a higher median residual SYNTAX score was observed after primary percutaneous coronary intervention than the non-ELC group [8 (4-12) vs. 3 (0-8), P<0.001]. Furthermore, a multivariable regression analysis showed that ELC was an independent predictor of the residual SYNTAX score (β=3.620, P<0.001). Conclusions The presence of ELC was significantly associated with the anatomical severity of diseased coronary vessels in patients with STEMI who required emergency clinical judgment and treatment.

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“…DELC has been identified in the medical literature as a surrogate marker for identifying high-risk patients with occult atherosclerosis [3][4][5]. It has been found to be more prevalent in males, and a statistically significant positive association was observed between DELC and conditions such as diabetes mellitus, hypertension, myocardial infarction and coronary artery disease in both sexes [6].…”

Section: Introductionmentioning

confidence: 99%

Relationship between diagonal earlobe crease (Frank's sign) and international index of erectile dysfunction score (IIEF-5)

2023

Journal of Men's Health

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The objective of this study is to examine the association between erectile dysfunction (ED) and the presence of diagonal earlobe crease (DELC), a physical sign commonly associated with atherosclerosis. A total of 96 male patients, aged between 50 and 65 years, were referred to our institute between December 2020 and March 2021 for various urological conditions. These patients were included in the study. Erectile performance was assessed using the IIEF-5 score, and DELC was visually identified by a urologist. The patients were administered the IIEF-5 questionnaire, and the results were categorized into two groups: the DELC group included patients with an earlobe crease, while non-DELC group consisted of patients with normal earlobes. In total, 96 patients participated in the study. We observed a decrease in IIEF-5 scores among patients in the DELC group compared to those in the non-DELC group. A statistically significant difference was found between the DELC group and the non-DELC group (p < 0.01). This study demonstrates that the presence of an earlobe crease may serve as a predictive sign of atherogenic erectile dysfunction in male patients aged 50–65 years. Further investigations should be conducted to explore the utility of DELC as a standard indicator during the physical examination of erectile dysfunction.

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Presence of ear lobe crease may predict intermediate and high-risk patients with acute non-ST elevation acute coronary syndrome

Cited by 10 publications

References 35 publications

Earlobe Creases as a Marker of the Risk for Coronary Atherosclerosis Before Angiography in Elderly and Non-elderly Patients

Earlobe Creases as a Marker of the Risk for Coronary Atherosclerosis Before Angiography in Elderly and Non-elderly Patients

Relationship between Earlobe Crease and Anatomical Severity of Coronary Artery Disease in ST-segment Elevation Myocardial Infarction

Relationship between diagonal earlobe crease (Frank's sign) and international index of erectile dysfunction score (IIEF-5)

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