Presence of digestible starch impacts <i>in vitro</i> fermentation of resistant starch

Klostermann, Cynthia E.; Endika, Martha F.; Kouzounis, Dimitrios; Buwalda, Piet L.; de Vos, Paul; Zoetendal, Erwin G.; Bitter, Johannes H.; Schols, Henk A.

doi:10.1039/d3fo01763j

Cited by 4 publications

(3 citation statements)

References 67 publications

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“…We were able to affiliate one of these ASVs to the species Bifidobacterium pseudolongum that was particularly abundant in the R+ CTR group (0.5%). Increase in Bifidobacterium content was observed often in relation with resistant starch fermentation 40 , 41 . The starch contained in cereal grains is the main energy source in poultry diets.…”

Section: Discussionmentioning

confidence: 97%

Relationship between feed efficiency and gut microbiota in laying chickens under contrasting feeding conditions

Bernard,

Lecoeur,

Coville

et al. 2024

Sci Rep

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The gut microbiota is known to play an important role in energy harvest and is likely to affect feed efficiency. In this study, we used 16S metabarcoding sequencing to analyse the caecal microbiota of laying hens from feed-efficient and non-efficient lines obtained by divergent selection for residual feed intake. The two lines were fed either a commercial wheat-soybean based diet (CTR) or a low-energy, high-fibre corn-sunflower diet (LE). The analysis revealed a significant line x diet interaction, highlighting distinct differences in microbial community composition between the two lines when hens were fed the CTR diet, and more muted differences when hens were fed the LE diet. Our results are consistent with the hypothesis that a richer and more diverse microbiota may play a role in enhancing feed efficiency, albeit in a diet-dependent manner. The taxonomic differences observed in the microbial composition seem to correlate with alterations in starch and fibre digestion as well as in the production of short-chain fatty acids. As a result, we hypothesise that efficient hens are able to optimise nutrient absorption through the activity of fibrolytic bacteria such as Alistipes or Anaerosporobacter, which, via their production of propionate, influence various aspects of host metabolism.

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Section: Discussionmentioning

confidence: 97%

Relationship between feed efficiency and gut microbiota in laying chickens under contrasting feeding conditions

Bernard,

Lecoeur,

Coville

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…While many gut microbiota express α-amylases that can break down soluble starch, only a small number of gut microbiota can break down resistant starch, which is insoluble and highly resistant to digestion. The easily digestible starch fermented readily, producing acetate and lactate, while the resistant starch fermented much more slowly, producing acetate and butyrate [48]. RS is categorized into five categories.…”

Section: Resistant Starch (Rs)mentioning

confidence: 99%

The Role of Prebiotics in Modulating Gut Microbiota: Implications for Human Health

Yoo,

Jung,

Kwak

et al. 2024

IJMS

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The human gut microbiota, an intricate ecosystem within the gastrointestinal tract, plays a pivotal role in health and disease. Prebiotics, non-digestible food ingredients that beneficially affect the host by selectively stimulating the growth and/or activity of beneficial microorganisms, have emerged as a key modulator of this complex microbial community. This review article explores the evolution of the prebiotic concept, delineates various types of prebiotics, including fructans, galactooligosaccharides, xylooligosaccharides, chitooligosaccharides, lactulose, resistant starch, and polyphenols, and elucidates their impact on the gut microbiota composition. We delve into the mechanisms through which prebiotics exert their effects, particularly focusing on producing short-chain fatty acids and modulating the gut microbiota towards a health-promoting composition. The implications of prebiotics on human health are extensively reviewed, focusing on conditions such as obesity, inflammatory bowel disease, immune function, and mental health. The review further discusses the emerging concept of synbiotics—combinations of prebiotics and probiotics that synergistically enhance gut health—and highlights the market potential of prebiotics in response to a growing demand for functional foods. By consolidating current knowledge and identifying areas for future research, this review aims to enhance understanding of prebiotics’ role in health and disease, underscoring their importance in maintaining a healthy gut microbiome and overall well-being.

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“…Fungal diastase, derived from Aspergillus oryzae, aids carbohydrate digestion in pancreatic insufficiency, enhancing nutrient absorption, but may cause mild adverse effects in some individuals [22]. Pancreatic enzyme supplementation remains a crucial therapeutic strategy, with formulation choice tailored to patient needs and conditions.…”

Section: Pancreatic Enzyme Supplementationmentioning

confidence: 99%

Exploring Therapeutic Digestive Enzyme Landscape in India: Current Evidence, Profit Motives, Regulations, and Future Perspectives

Singh,

Agrawal,

Saurabh

et al. 2024

Cureus

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This analysis critically examines the profit-driven marketing of digestive enzymes as over-the-counter (OTC) supplements in the context of India, expressing ethical concerns regarding pharmaceutical companies prioritizing financial gain over genuine public health needs within the lucrative OTC supplement market. The review delves into various enzymes, their mechanisms of action, uses, adverse drug reactions, and provides evidence from various studies. The research method involves the exploration of profit-driven strategies employed by pharmaceutical companies, addressing regulatory challenges, investigating the gap between dietary supplements and pharmaceutical drugs, and emphasizing the impact of direct-to-consumer advertising on self-diagnosis and overuse. Additionally, the study reviews various e-pharmacy platforms in India, assessing formulations and pricing. Key findings highlight the diverse formulations on these platforms, exposing insights into cost variations and indicating a regulatory gap that necessitates a comprehensive re-evaluation by Indian and international authorities. The analysis emphasizes the influence of direct-to-consumer advertising on behavior and potential health risks, raising ethical concerns about oversimplified health claims that overlook the necessity for individualized treatment plans. In conclusion, the study underscores the ethical complexity of prioritizing profit over public health and advocates for regulatory re-evaluation, exploring broader implications such as cultural influences and alternative therapies. The evolving landscape, featuring plant-based and microbe-derived alternatives, is presented as transformative, particularly in conditions like celiac disease.

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Presence of digestible starch impacts in vitro fermentation of resistant starch

Abstract: Awareness is required for the presence of digestible starch when studying in vitro fermentation of resistant starch (RS). Such starch may steer and overrule the fermentation of RS, thereby affecting the evaluation of the prebiotic potential of RS.

Cited by 4 publications

References 67 publications

Relationship between feed efficiency and gut microbiota in laying chickens under contrasting feeding conditions

Relationship between feed efficiency and gut microbiota in laying chickens under contrasting feeding conditions

The Role of Prebiotics in Modulating Gut Microbiota: Implications for Human Health

Exploring Therapeutic Digestive Enzyme Landscape in India: Current Evidence, Profit Motives, Regulations, and Future Perspectives

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