Presence of Coronary Plaques in Patients with Nonalcoholic Fatty Liver Disease

Abstract

Patients with NAFLD, even without metabolic syndrome, are at high risk for atherosclerosis. Assessment of NAFLD may be helpful for cardiovascular risk stratification.

Impaired Myocardial Perfusion Reserve in Patients With Fatty Liver Disease Assessed by Quantitative Myocardial Perfusion Magnetic Resonance Imaging

“…Fatty liver was considered to be present when the liver Hounsfield units (HU) were less than the spleen HU minus 10 on plain CT (Figure 1). 5,19 The reviewers who measured liver and spleen attenuation were blinded to individual clinical information. The hepatic attenuation was measured by means of a random selection of 3 circular regions of interest (ROI) on 3 transverse sections at different levels of the liver.…”

“…1-3 For a long time, the presence of NAFLD was considered a benign condition with little or no clinical significance. 4 However, recent results indicate that individuals with NAFLD, even without metabolic syndrome (MetS), are at high risk for coronary artery disease (CAD) 5 and the severity of the liver histology in NAFLD patients is closely associated with intima-media thickness. 2,3,6,7 Furthermore, Villanova et al showed that NAFLD is a risk factor for endothelial dysfunction, by evaluating the flowmediated vasodilatation of the brachial artery.…”

Nonalcoholic fatty liver disease and cardiovascular risk

“…Importantly, this association was independent of the traditional risk factors for coronary artery disease [21] . Assy et al [21] described that the presence of NAFLD was associated with increased prevalence of non-calcified coronary plaques, independent of metabolic syndrome, in a case-controlled study. Another study showed a significant association in NAFLD patients and the appearance of vulternable plaques on coronary artery imaging [22,23] .…”

Body fat distribution: the answer to the apparent paradox of obesity in cardiology?

“…Так, ско-рость синтеза СЖК, а также их высвобождение в ответ на воздействие катехоламинов в ЭЖТ значительно выше, чем в других жировых депо. Интенсивный ли-полиз в эпикардиальных адипоцитах может быть свя-зан с низкой чувствительностью к действию инсулина и большим количеством β3-адренорецепторов [42]. Также для ЭЖТ характерно большее содержание белка и низкая способность к окислению глюкозы по срав-нению с ВЖТ [43].…”