Presence of ChAT mRNA and a very marked α7nAChR immunoreaction in the synovial lining layer of the knee joint

Forsgren, Sture

doi:10.1016/j.lfs.2012.03.028

Cited by 12 publications

(9 citation statements)

References 24 publications

(33 reference statements)

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“…As a complement to these observations, a7 nAChR knockout mice present an exacerbated response in the collagen-induced arthritis model (van Maanen et al, 2010). The presence of choline acetyltransferase Therapeutic Potential of a7 nAChRs mRNA and marked expression of a7 nAChRs was reported in the pannus of the knee joint, supporting the hypothesis that this nAChR subtype is involved in OA (Forsgren, 2012).…”

Section: G A7 Nicotinic Acetylcholine Receptors and The Immune Connementioning

confidence: 63%

Therapeutic Potential ofα7 Nicotinic Acetylcholine Receptors

et al. 2015

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Section: G A7 Nicotinic Acetylcholine Receptors and The Immune Connementioning

confidence: 63%

Therapeutic Potential ofα7 Nicotinic Acetylcholine Receptors

et al. 2015

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“…ChAT mRNA and protein were localized to fibroblast-like and macrophage-like cells as well as to some extent in blood vessel walls of the synovial sample, while α 7 -nAChR was mostly found in the synovial intimal lining layer [197]. Recently, our group could show that different nAChR and mAChR as well as CarAT, transporters, and ACh-degrading enzymes are present in the synovial tissue of the human joint [198].…”

Section: Musculoskeletal Systemmentioning

confidence: 99%

The Non-Neuronal Cholinergic System in Health and Disease

Beckmann¹,

Lips²

2013

Pharmacology

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Acetylcholine (ACh) is not only a neurotransmitter but is an ancient molecule that can be released by and act on non-neuronal cells. In these cells the system of ACh-synthesizing enzymes, transporters, receptors and degrading enzymes is termed the non-neuronal cholinergic system (NNCS). There is increasing evidence that the NNCS is dysregulated in various diseases and can have an influence on their pathology. However, for many organ systems not much is known about the expression and function of the NNCS. Thus, this review focusses on the role of the NNCS in different organ systems in health and disease. Dysregulation of ACh synthesis and release, mutations or polymorphisms in genes encoding NNCS components, and auto-antibodies against NNCS components are common factors influencing disease progression. Pharmacological agents targeting the NNCS are already successfully in clinical use for some disorders, indicating that interfering with this system is very promising and more research is needed to elucidate the role of the NNCS in different tissues and pathological states.

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“…Thus, ChAT is expressed by the synovial membrane, but the cell type that secretes ChAT and whether Ach is produced because of this synovial ChAT remain unclear [17,72]. Synoviocytes and macrophages express a range of nicotinic subunits including alpha-7 homopentamer [16,73,74]. The OA synovial membrane also expresses choline transporters and muscarinic receptors 1, 3, 4, and 5 and nicotinic subunits alpha-3, -5, -6, -7, -9, and -10 [17,75].…”

Section: Pns and Synoviummentioning

confidence: 99%

“…Furthermore, most resident cells of osteoarticular tissue have receptors for sympathetic and parasympathetic neurotransmitters and thus may respond to their stimuli. Ach and norepinephrine (NE), as major parasympathetic and sympathetic mediators, respectively, could be produced locally by non-neuronal cells and therefore affect joint tissue homeostasis regardless of autonomic innervation [12,16,17]. In addition, despite its lack of innervation, the cartilage may be affected by catecholaminergic and cholinergic mediators, produced locally in the bone or synovium, because chondrocytes express most of their receptors.…”

Section: Introductionmentioning

confidence: 99%

Role of the autonomic nervous system in osteoarthritis

Courties

Sellam

Bérenbaum

2017

Best Practice & Research Clinical Rheumatology

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a b s t r a c tJoint homeostasis is affected by local and systemic processes. Catecholaminergic and cholinergic fibers innervate the synovium, trabecular bone, and periosteum. Several studies have investigated the involvement of the autonomic nervous system (ANS) in joint homeostasis and the pathophysiology of osteoarthritis (OA). Various resident cells of osteoarticular tissues express receptors for sympathetic and parasympathetic neurotransmitters (norepinephrine/epinephrine and acetylcholine, respectively), which enables them to respond to autonomic stimuli. Furthermore, some of these cells are also able to synthesize neurotransmitters locally and secrete them, which may then act locally regardless of autonomic innervation. The sympathetic nervous system (SNS) is known for promoting bone loss, which has also been demonstrated in the subchondral bone during OA. However, it could interfere with other mechanisms in joint homeostasis. Indeed, intake of beta-blockers decreases pain sensation in individuals with OA; hence, the SNS could be one of the systemic links between hypertension and OA. Parasympathetic fibers may also be implicated in joint homeostasis and local control of inflammation. The vagus nerve has been found to have a strong antiinflammatory action in other rheumatic diseases through the nicotinic alpha-7 receptor, which is locally expressed by most joint

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Presence of ChAT mRNA and a very marked α7nAChR immunoreaction in the synovial lining layer of the knee joint

Cited by 12 publications

References 24 publications

Therapeutic Potential ofα7 Nicotinic Acetylcholine Receptors

Therapeutic Potential ofα7 Nicotinic Acetylcholine Receptors

The Non-Neuronal Cholinergic System in Health and Disease

Role of the autonomic nervous system in osteoarthritis

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