Presence of CC Genotype for rs17773430 Could Affect the Percentage of Excess Weight Loss 1 Year After Bariatric Surgery: Tehran Obesity Treatment Study (TOTS)

Javanrouh, Niloufar; Khalaj, Alireza; Guity, Kamran; Sedaghati-Khayat, Bahareh; Barzin, Maryam; Daneshpour, Maryam S.

doi:10.1007/s11695-019-04211-w

Cited by 7 publications

(7 citation statements)

References 12 publications

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“…BMI at the start of the study ranged from 43 to 51 kg/m 2 . On the other hand, Javanrouh et al found that patients with the rs17773430 variant of MC4R experienced a greater reduction in percent excess weight loss (%EWL) up to 12 months after gastric bypass [21]. Mirshahi et al also reported improved weight loss in patients with the rs5282087 variant in the MC4R promoter region [22].…”

Section: Mc4rmentioning

confidence: 99%

A Systematic Review of Genetic Correlates of Weight Loss After Bariatric Surgery

et al. 2021

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This systematic review synthesized research evaluating the relationship between genetic predictors and weight loss after bariatric surgery. Fifty-seven studies were identified that examined single genes or genetic risk scores. Uncoupling protein (UCP) rs660339 was associated with excess weight loss after surgery in 4 of 6 studies. The most commonly assessed genes were fat mass and obesity-associated (FTO) gene (n = 10) and melanocortin-4 receptor (MC4R) (n = 14). Both were inconsistently related to weight loss. Genetic risk scores predicted weight loss in 6 of 7 studies. This evidence suggests the potential of using genetic variants and genetic risk scores to predict the amount of weight loss anticipated after bariatric surgery and identify patients who may be at risk for suboptimal weight reduction.

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Section: Mc4rmentioning

confidence: 99%

A Systematic Review of Genetic Correlates of Weight Loss After Bariatric Surgery

et al. 2021

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“…Follow‐up ranged from 6 months to 7 years. Weight loss was expressed as change in BMI in 11 studies, 25–34 percentage excess BMI loss (EBMIL) in one study, 35 percentage TWL in nine studies, 36–44 and excess weight loss (EWL) in 29 studies 45–73 . Patients underwent various types of bariatric procedures including RYGB, SG, and LAGB.…”

Section: Resultsmentioning

confidence: 99%

“…In contrast, the rs17773430 and rs5282087, which are highly correlated, had a positive association with weight loss. Javanrouh et al showed that the rs17773430 variant was related to greater weight loss 12 months after surgery 62 . Mirshahi et al concluded that patients with the rs5282087 variant are predisposed to lower weight at nadir, the lowest recorded weight (%EWL 65 ± 0.5% vs. 72 ± 0.1% and 73 ± 0.6% of baseline weight), after RYGB surgery 66 …”

Section: Resultsmentioning

confidence: 99%

Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review

van der Meer,

Mohamed,

Monpellier

et al. 2023

Obesity Reviews

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SummaryThe extent to which genetic variations contribute to interindividual differences in weight loss and metabolic outcomes after bariatric surgery is unknown. Identifying genetic variants that impact surgery outcomes may contribute to clinical decision making. This review evaluates current evidence addressing the association of genetic variants with weight loss and changes in metabolic parameters after bariatric surgery. A search was conducted using Medline, Embase, Scopus, Web of Science, and Cochrane Library. Fifty‐two eligible studies were identified. Single nucleotide polymorphisms (SNPs) at ADIPOQ (rs226729, rs1501299, rs3774261, and rs17300539) showed a positive association with postoperative change in measures of glucose homeostasis and lipid profiles (n = 4), but not with weight loss after surgery (n = 6). SNPs at FTO (rs11075986, rs16952482, rs8050136, rs9939609, rs9930506, and rs16945088) (n = 10) and MC4R (rs11152213, rs476828, rs2229616, rs9947255, rs17773430, rs5282087, and rs17782313) (n = 9) were inconsistently associated with weight loss and metabolic improvement. Four studies examining the UCP2 SNP rs660339 reported associations with postsurgical weight loss. In summary, there is limited evidence supporting a role for specific genetic variants in surgical outcomes after bariatric surgery. Most studies have adopted a candidate gene approach, limiting the scope for discovery, suggesting that the absence of compelling evidence is not evidence of absence.

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“…In another study, we found nine correlated SNPs upstream of the PPARG gene are signi cantly involved in long-term and persistent obesity [26]. Four SNPs belonging to the MC4R gene were also signi cantly involved in the percentage of excess weight loss (EWL%) and BMI weight loss (EBMIL%), especially after 12 months of bariatric surgery [27]. Furthermore, rs13107325 was signi cantly associated with the increased likelihood of persistent metabolically healthy obesity in menopaused women [28].…”

Section: Resultsmentioning

confidence: 99%

Title: Cohort profile update: Tehran Cardiometabolic Genetic Study, a path toward precision medicine

Daneshpour

Lanjanian

Sedaghati-Khayat

et al. 2022

Preprint

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The Tehran Cardiometabolic Genetic Study (TCGS) is a large population-based cohort study with periodic follow-ups, which created a comprehensive database of 20,367 participants born between 1911-2015 selected from 4 different longitudinal, ongoing, and family-based studies. The study aims to identify the potential targets for prevention and intervention for non-communicable diseases in mid-life and late life. The study focuses on cardiovascular, endocrine, metabolic abnormalities, cancers, and some inherited diseases. Since 2017, the cohort expanded the information by coding all health-related complications (hospitalization outcomes and self-reports) based on ICD11 coding and confirming the consanguineous marriage with genetic markers. This article presents an update on the rationale and design of the study. We also present a summary of our findings and our goals toward precision medicine.

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Presence of CC Genotype for rs17773430 Could Affect the Percentage of Excess Weight Loss 1 Year After Bariatric Surgery: Tehran Obesity Treatment Study (TOTS)

Cited by 7 publications

References 12 publications

A Systematic Review of Genetic Correlates of Weight Loss After Bariatric Surgery

A Systematic Review of Genetic Correlates of Weight Loss After Bariatric Surgery

Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review

Title: Cohort profile update: Tehran Cardiometabolic Genetic Study, a path toward precision medicine

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