Presence of calcium antagonist activity explains the use ofSyzygium samarangense in diarrhoea

Ghayur, Muhammad Nabeel; Gilani, Anwarul Hassan; Khan, Arif‐ullah; Amor, Evangeline C.; Villaseñor, Irene M.; Choudhary, M. Iqbal

doi:10.1002/ptr.1801

Cited by 47 publications

(42 citation statements)

References 11 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The contraction of smooth muscle induced by high K + is dependent, in turn, upon the entry of Ca 2+ into the cells through voltage activated ion channels, while inhibition of high K + -induced contraction results from the prevention of Ca 2+ entry through these channels (Al-Zuhair et al, 1996;Bolton, 1979), a characteristic of calcium channel blockers (CCB). It was observed previously that the antispasmodic constituents present in various medicinal plants mediate their effect usually through a CCB action (Ghayur et al, 2006;Gilani et al, 2006;Shah et al, 2010). In order to elucidate the possible mechanism of the antispasmodic effect of CF, we investigated the interference of CF with voltage operated calcium channels.…”

Section: Resultsmentioning

confidence: 99%

Antispasmodic effect of Jatropha gossypiifolia is mediated through dual blockade of muscarinic receptors and Ca2+ channels

Silva¹,

Abreu²,

Freire³

et al. 2011

Rev. bras. farmacogn.

View full text Add to dashboard Cite

Abstract:The antispasmodic activity of Jatropha gossypiifolia L., Euphorbiaceae, aerial parts was investigated in rodents using the mouse intestinal transit model and acetylcholine (ACh, to 10 -4 M) and calcium (CaCl 2 , 10 -4 to 10 -1 M)-induced contractions of isolated rat jejunum. Similar to atropine (1 mg/kg), oral doses of ethanolic extract (EE) of J. gossypiifolia (500, 1000 and 2000 mg/kg) produced a decrease in intestinal transit (37.6 to 57.1%) when compared with control. The ACh-induced contraction in the jejunum was inhibited by EE (0.5, 1.0 and 2.0 mg/ mL), chloroformic (CF) and aqueous fractions (0.1 and 0.5 mg/mL) and methanolic subfraction (0.05 and 0.25 mg/mL), suggesting an antimuscarinic mechanism. CaCl 2 -induced responses in jejunum were also attenuated in the presence of CF (0.05 and 0.1 mg/mL) implying a direct interference of CF with the influx of calcium ions in the cells. Only the organic fraction of the extract had a calcium-antagonist effect, whereas both chloroformic and aqueous fractions had anticholinergic effect. These results suggest that the antispasmodic effect of J. gossypiifolia may be due a combination of anticholinergic and calcium antagonist mechanisms.

show abstract

Section: Resultsmentioning

confidence: 99%

Antispasmodic effect of Jatropha gossypiifolia is mediated through dual blockade of muscarinic receptors and Ca2+ channels

Silva¹,

Abreu²,

Freire³

et al. 2011

Rev. bras. farmacogn.

View full text Add to dashboard Cite

show abstract

“…An uncommon feature is the additional C-methylation in 1 and 2; these compounds have been previously isolated from the leaves of this plant and reported to have antidiabetic properties (Resurreccion-Magno et al, 2005), antibacterial (Gafner, Wolfender, Mavi & Hostettmann, 1996), spasmolitic (Amor et al, 2005;Ghayur et al, 2006) properties, and inhibited prolyl endopeptidase (Amor, et al, 2004). This is the first report of the isolation of chalcone 3 from S. samarangense.…”

Section: Resultsmentioning

confidence: 80%

“…Ethanolic leaf extract exhibited immunostimulant activity (Srivastava, Shaw & Kulshreshtha, 1995), the hexane extract was found to relax the hypermotility of the gut (Ghayur, Gilani, Khan, Amor, Villasenor & Choudhary, 2006), while the alcoholic extract of the stem bark showed antibacterial activity (Chattopadhayay, Sinha & Vaid, 1998).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic chalcones and antioxidants from the fruits of Syzygium samarangense (Wax Jambu)

et al. 2008

View full text Add to dashboard Cite

Bioassay-guided fractionation of the methanolic extracts of the pulp and seeds of the fruits of Syzygium samarangense Merr. & Perry (Blume) led to the identification of four cytotoxic compounds and eight antioxidants on the basis of HPLC-PDA analysis, MS, and various NMR spectroscopic techniques. Three C-methylated chalcones, 2′,4′-dihydroxy-3′,5′-dimethyl-6′-methoxychalcone (1), 2′,4′-dihydroxy-3′-methyl-6′-methoxychalcone (stercurensin, 2), and 2′,4′-dihydroxy-6′-methoxychalcone (cardamonin, 3), were isolated and displayed cytotoxic activity (IC 50 = 10, 35, and 35 μM, respectively) against the SW-480 human colon cancer cell line. Also a number of known antioxidants were obtained including six quercetin glycosides: reynoutrin (4), hyperin (5), myricitrin (6), quercitrin (7), quercetin (9), and guaijaverin (10), one flavanone: (S)-pinocembrin (8), and two phenolic acids: gallic acid (11) and ellagic acid (12).

show abstract

“…Immunomodulatory effects have also been described for a number of flavonoids isolated from the acetone extract of leaves of the plant, as demonstrated through their inhibitory potency on human peripheral blood mononuclear cells proliferation activated by phytohemagglutinin (Kuo et al, 2004). Four flavonoids isolated from hexane extract of the plant showed spasmolytic and calcium antagonist activities, validating the anti-diarrheal use of the plant in folk medicine (Ghayur et al, 2006).…”

Section: Introductionmentioning

confidence: 82%

Antihyperglycemic Activities of Leaves of Three Edible Fruit Plants (<i>Averrhoa carambola, Ficus hispida</i> and <i>Syzygium samarangense</i>) of Bangladesh

Shahreen¹,

Banik²,

Hafiz³

et al. 2012

Afr. J. Trad. Compl. Alt. Med.

View full text Add to dashboard Cite

Averrhoa carambola L. (Oxalidaceae), Ficus hispida L.f. (Moraceae), and Syzygium samarangense (Blume) Merr. & L.M. Perry (Myrtaceae) are three common plants in Bangladesh, the fruits of which are edible. The leaves and fruits of A. carambola and F. hispida are used by folk medicinal practitioners for treatment of diabetes, while the leaves of S. samarangense are used for treatment of cold, itches, and waist pain. Since scientific studies are absent on the antihyperglycemic effects of the leaves of the three plants, it was the objective of the present study to evaluate the antihyperglycemic potential of methanolic extract of leaves of the plants in oral glucose tolerance tests carried out with glucose-loaded mice. The extracts at different doses were administered one hour prior to glucose administration and blood glucose level was measured after two hours of glucose administration (p.o.) using glucose oxidase method. Significant oral hypoglycemic activity was found with the extracts of leaves of all three plants tested. The fall in serum glucose levels were dose-dependent for every individual plant, being highest at the highest dose tested of 400 mg extract per kg body weight. At this dose, the extracts of A. carambola, F. hispida, and S. samarangense caused, respectively, 34.1, 22.7, and 59.3% reductions in serum glucose levels when compared to control animals. The standard antihyperglycemic drug, glibenclamide, caused a 57.3% reduction in serum glucose levels versus control. Among the three plants evaluated, the methanolic extract of leaves of S. samarangense proved to be the most potent in demonstrating antihyperglycemic effects. The result validates the folk medicinal uses of A. carambola and F. hispida in the treatment of diabetes, and indicates that the leaves of S. samarangense can also possibly be used for amelioration of diabetes-induced hyperglycemia.

show abstract

Presence of calcium antagonist activity explains the use ofSyzygium samarangense in diarrhoea

Cited by 47 publications

References 11 publications

Antispasmodic effect of Jatropha gossypiifolia is mediated through dual blockade of muscarinic receptors and Ca2+ channels

Antispasmodic effect of Jatropha gossypiifolia is mediated through dual blockade of muscarinic receptors and Ca2+ channels

Cytotoxic chalcones and antioxidants from the fruits of Syzygium samarangense (Wax Jambu)

Antihyperglycemic Activities of Leaves of Three Edible Fruit Plants (<i>Averrhoa carambola, Ficus hispida</i> and <i>Syzygium samarangense</i>) of Bangladesh

Contact Info

Product

Resources

About