Presence of Birefringent Crystals Is Useful in Distinguishing Thyroid From Parathyroid Gland Tissues

Isotalo, Phillip A.; Lloyd, Ricardo V.

doi:10.1097/00000478-200206000-00019

Cited by 32 publications

(17 citation statements)

References 4 publications

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“…The presence of birefringent crystals supports an origin in the thyroid gland. 9 Perrier et al suggested that measurement of intraoperative parathyroid hormone levels is helpful to distinguish between thyroid and parathyroid tissue. 10 FNAs of PL can be diagnosed correctly if one pays attention to cytologic and clinical features.…”

Section: Discussionmentioning

confidence: 99%

Fine Needle Aspiration of Parathyroid Lesions

Liu

Gnepp

Pisharodi³

2004

Acta Cytologica

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Section: Discussionmentioning

confidence: 99%

Fine Needle Aspiration of Parathyroid Lesions

Liu

Gnepp

Pisharodi³

2004

Acta Cytologica

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“…The follicles contain a colloid-like material and may be distinguished from normal and neoplastic thyroid tissue by the presence of birefringent calcium oxalate crystals that may be present in the latter. 20 This approach is particularly useful during frozen examination. Adenoma variants include oncocytic adenomas, (Figure 3b) lipoadenomas (hamartomas) (Figure 3c) and clear cell adenomas (Figure 3d).…”

Section: Parathyroid Adenomamentioning

confidence: 99%

Parathyroid tumors and related disorders

2011

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Primary hyperparathyroidism (P-HPT) is a common endocrine disorder that occurs as a result of adenomas (80-85%), hyperplasias (10-15%) or carcinomas (o1%) of the parathyroid glands. Molecular genetic analyses of heritable P-HPT syndromes have provided considerable insight into the understanding of sporadic parathyroid tumors and hyperplasias. This review will focus on the criteria for classification of parathyroid proliferative disorders and will highlight our understanding of these lesions at the molecular level. Advances in radiological imaging techniques together with the rapid intraoperative parathyroid hormone assay will be reviewed with respect to current treatment approaches for P-HPT.

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“…When clinical hyperparathyroidism is not evident, hyperplastic or adenomatous parathyroid tissue showing typical trabecular arrangement might be confused with follicular cell-derived nodules or even medullary carcinoma. In the presence of a follicular patterned associated component, the recognition of bi-refringent crystals is useful in distinguishing thyroid from parathyroid gland tissues [35]. More complicated is the differential diagnosis between malignant thyroid nodules -i.e., PD carcinomaand parathyroid carcinoma involving the thyroid gland, which present vascular and capsular invasion, trabecular growth with sometimes oncocytic changes, and, in a fraction of cases, necrosis and mitotic activity.…”

Section: Extra-thyroidal Lesionsmentioning

confidence: 99%

A Practical Diagnostic Approach to Solid/Trabecular Nodules in the Thyroid

Volante

Papotti

2008

Endocr Pathol

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Nodules having a non-follicular-non-papillary structure may be frequently encountered in the thyroid, the solid/trabecular arrangement being the most common feature. When solid/trabecular pattern is predominant within a thyroid nodule, the wide range of differential diagnoses represents one of the major diagnostic problems in the routine thyroid practice, including--among others--relatively frequent entities such as trabecular adenoma or solid variant of papillary carcinoma and rare tumors such as hyalinizing trabecular tumor or paraganglioma. Morphology alone may not be sufficient to proper-type solid/trabecular tumors in the thyroid and, therefore, a panel of immunohistochemical markers is recommended, including thyroglobulin/calcitonin as the first step, followed by specific markers according to the morphological and clinical setting. A schematic algorithm is presented, which takes into consideration the diagnostic hallmarks of the most relevant entities that enter in the differential diagnosis in solid/trabecular nodules within the thyroid.

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Presence of Birefringent Crystals Is Useful in Distinguishing Thyroid From Parathyroid Gland Tissues

Cited by 32 publications

References 4 publications

Fine Needle Aspiration of Parathyroid Lesions

Fine Needle Aspiration of Parathyroid Lesions

Parathyroid tumors and related disorders

A Practical Diagnostic Approach to Solid/Trabecular Nodules in the Thyroid

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