Presence of autocrine hepatocyte growth factor-Met signaling and its role in proliferation and migration of SNU-484 gastric cancer cell line

Park, Minseon; Park, Hyelee; Kim, Wook Hwan; Cho, Hyeseong; Lee, Jae Ho

doi:10.1038/emm.2005.29

Cited by 30 publications

(16 citation statements)

References 29 publications

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“…However, the remarkable technical advances in molecular biology seen in recent years have enhanced the understanding of carcinogenesis and the progression of cancer. Normal growth and differentiation of cells in the gastrointestinal tract are regulated by autocrine and paracrine secretion of peptide growth factors which are responsible for controlling maturation, differentiation and apoptosis (Moss, 1998;Park et al, 2005). In gastric cancer, where there is unrestricted growth, it is likely that there are abnormalities of secretion or response to those peptides.…”

Section: Discussionmentioning

confidence: 99%

PTEN/MMAC1 enhances the growth inhibition by anticancer drugs with downregulation of IGF-II expression in gastric cancer cells

Hwang

Kim²,

Lee³

et al. 2005

Exp Mol Med

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Section: Discussionmentioning

confidence: 99%

PTEN/MMAC1 enhances the growth inhibition by anticancer drugs with downregulation of IGF-II expression in gastric cancer cells

Hwang

Kim²,

Lee³

et al. 2005

Exp Mol Med

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“…Although, the exact role of multinucleated cells in these pathophysiological conditions is not clear, it certainly contributes to increase the genomic and morphological alterations during cell division. Importance of genomic instability in carcinogenesis can not be further emphasized (Park et al, 2005). Interestingly, genomic instability is also considered as one of the major causative factors in aging.…”

Section: Inhibition Of Intracellular Ros Levels Reduced the Occurrencmentioning

confidence: 99%

Centrosome amplification and multinuclear phenotypes are Induced by hydrogen peroxide

Chae

Yun²,

Um³

et al. 2005

Exp Mol Med

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Multinucleated cells resulted from mitosis defect have been noted in pathophysiological states of the cells such as inflammation, senescence and cancer. Since oxidative stress has been known to correlate with these pathophysiological conditions, we tested the effect of H 2 O 2 on the cell cycle progression and formation of multinucleated cells. H2O2 induced a significant delay in cell cycle progression in Chang liver cells. Interestingly, H 2 O 2 actively induced hyperamplification of centrosomes (n 3) and multipolar spindle formation during mitosis and subsequently increased the generation of multinucleated cells. A significant increase of the phospho-ERK level was observed upon H2O2 treatment but PD98059, an MEK1/2 inhibitor, didn't reduce the frequency of cells with hyperamplified centrosomes. On the other hand, treatment of either H 2 O 2 or adriamycin increased intracellular ROS levels and multinucleated cells, which were significantly suppressed by antioxidants, N-acetylcysteine and PDTC. Thus, our results suggest that oxidative stress can trigger centrosome hyperamplification and multinucleated cell formation, which may promote pathophysiological progression.

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“…The emergence of cancer-specific autocrine and paracrine signals originating from tumor cells often includes the supraphysiological expression of secretory proteins or their receptors (Sporn and Roberts, 1985;Welsh et al, 2003;Park et al, 2005). Proteins that are secreted from neoplastic cells into the extracellular microenvironment are taken-up into the bloodstream.…”

Section: Introductionmentioning

confidence: 99%

Identification of potential lung cancer biomarkers using an in vitro carcinogenesis model

et al. 2008

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Lung cancer is one of the deadliest and commonly diagnosed neoplasms. Early diagnosis of this disease is critical for improving clinical outcome and prognosis. Because the early stages of lung cancer often produce no symptoms, it is necessary to identify biomarkers for early detection, prognostic evaluation, and recurrence monitoring of the cancer. To identify potential lung cancer biomarkers, we analyzed the differential protein secretion from transformed bronchial epithelial cells (1198 and 1170-I) as compared to immortalized normal bronchial epithelial cells (BEAS-2B) and non-transformed cells (1799) all of which are derived from BEAS-2B and represent multistage bronchial epithelial carcinogenesis. The proteins recovered from the conditioned media of the cells were separated on two-dimensional gels. There was little difference between the secretome of the BEAS-2B and 1799 cells, whereas the patterns between the transformed 1198 and 1170-I cells and non-transformed 1799 cells were significantly different. Using mass spectrometry and database search, we identified 20 proteins including protein gene product 9.5 (PGP9.5), translationally controlled tumor protein (TCTP), tissue inhibitors of metalloproteinases-2 (TIMP-2), and triosephosphate isomerase (TPI), that were either increased or decreased simultaneously in conditioned media of both 1198 and 1170-I cells. Furthermore, levels of PGP9.5, TCTP, TIMP-2, and TPI were significantly increased not only in the conditioned media of both transformed cell lines when compared to those of BEAS-2B and 1799 cells, but also in plasmas and tissues from lung cancer patients when compared to those in normal controls. We suggest the PGP9.5, TCTP, TIMP-2, and TPI as promising candidates for lung cancer serum biomarkers.

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Presence of autocrine hepatocyte growth factor-Met signaling and its role in proliferation and migration of SNU-484 gastric cancer cell line

Cited by 30 publications

References 29 publications

PTEN/MMAC1 enhances the growth inhibition by anticancer drugs with downregulation of IGF-II expression in gastric cancer cells

PTEN/MMAC1 enhances the growth inhibition by anticancer drugs with downregulation of IGF-II expression in gastric cancer cells

Centrosome amplification and multinuclear phenotypes are Induced by hydrogen peroxide

Identification of potential lung cancer biomarkers using an in vitro carcinogenesis model

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