Présence de la 3,5,3′-triiodothyronamine dans le contenu intestinal du rat après administration de 3,5,3′-triiodo-l-thyronine

The Biliary Excretion and Enterohepatic Circulation of Drugs and Other Organic Compounds

“…Triiodothyronine is extensively excreted in the bile as a glucuronide and as a sulphate [96] and it is probable that these conjugates are hydrolyzed in the gut prior to decarboxylation. The amine has been detected in the intestinal contents and faeces of rats atter administration of physiological amounts of 3, 5, 3' -triiodo-L-thyronine, however, it is absent from bile indicating that it is formed in the gut [97]. This reaction may be of physiological significance since it has long been known that the decarboxylated products of the thyroid hormones, namely, thyroxamine and triiodothyronamine, are remarkably active in potentiating the inhibitory action of adrenaline on smooth muscle such as the intestine [98,99].…”