Présence d’une voie d’activation des neutrophiles IgG-induite dans l’anaphylaxie médicamenteuse

Chaisemartin, L. De; Jönsson, Friederike; Granger, Vanessa; Gouél‐Cheron, Aurélie; Gillis, Caitlin M.; Dib, F.; Nicaise-Roland, Pascale; Ganneau, Christelle; Guinnepain, M.T.; Aubier, Michel; Bay, Sylvie; Neukirch, Catherine; Tubach, Florence; Longrois, Dan; Chollet‐Martin, Sylvie; Bruhns, Pierre

doi:10.1016/j.reval.2018.02.115

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“…Detection of specific IgG in sera of patients who suffered from drug-induced AHR could provide useful additional information on the pathway involved. The specific IgG levels can be measured by ImmunoCAP 60 or classical ELISA, and has been used in the French cohort on IgG-induced NMBA-anaphylaxis, 61 although in this context, the difference of levels between patients and controls was insufficient, precluding clinical use.…”

Section: Endotype Of Mediators Responsible For An Acute Hypersensitiv...mentioning

confidence: 99%

Neuromuscular blocking agent induced hypersensitivity reaction exploration: an update

Dejoux

Chaisemartin

Bruhns

et al. 2022

European Journal of Anaesthesiology

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Acute hypersensitivity reactions (AHRs) occurring in present-day anaesthesia can have severe, sometimes fatal, consequences and their incidence is increasing. The most frequent allergens responsible for AHR during anaesthesia are neuromuscular blocking agents (NMBAs) (70% of the cases) followed by antibiotics (18%), patent blue dye and methylene blue dye (5%), and latex (5%). Following an AHR, strategies for subsequent anaesthetic procedures (especially the choice of an NMBA) may be difficult to formulate due to inconclusive diagnostic analysis in up to 30% of AHRs. Current diagnosis of AHR relies on the detection of mast cell degranulation products and drug-specific type E immunoglobulins (IgE) in order to document an IgE-mediated anaphylaxis (IgE endotype). Nonetheless, other IgE-independent pathways can be involved in AHR, but their detection is not currently available in standard situations. The different mechanisms (endotypes) involved in peri-operative AHR may contribute to the inconclusive diagnostic work-up and this generates uncertainty concerning the culpable drug and strategy for subsequent anaesthetic procedures. This review provides details on the IgE endotype; an update on non-IgE related endotypes and the novel diagnostic tools that could characterise them. This detailed update is intended to provide explicit clinical reasoning tools to the anaesthesiologist faced with an incomplete AHR diagnostic work-up and to facilitate the decision-making process regarding anaesthetic procedures following an AHR to NMBAs.

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Section: Endotype Of Mediators Responsible For An Acute Hypersensitiv...mentioning

confidence: 99%

Neuromuscular blocking agent induced hypersensitivity reaction exploration: an update

Dejoux

Chaisemartin

Bruhns

et al. 2022

European Journal of Anaesthesiology

View full text Add to dashboard Cite

show abstract

Présence d’une voie d’activation des neutrophiles IgG-induite dans l’anaphylaxie médicamenteuse

Cited by 1 publication

References 0 publications

Neuromuscular blocking agent induced hypersensitivity reaction exploration: an update

Neuromuscular blocking agent induced hypersensitivity reaction exploration: an update

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