Aphid is assumed one of the most severe pests attacking wheat causing harm to the plants either directly by sucking juice or indirectly as a vector of diseases. Host plant resistance is a sturdy component in Integrated Pest Management (IPM) to decrease the injury of aphid insects. We studied the population abundance and susceptibility of two Egyptian wheat cultivars (Misr 1 and Misr 3) to Aphid spp infestation. The results indicated that the total number of Aphids on wheat Misr 1 variety during the seasons, 2019-2020 and 2020-2021 were 536 and 191 respectively whereas, on Misr 3 variety were 1274 and 1388 respectively. The results of the simplecorrelation during 2020 season, aphid density was insignificantly correlated with a daily mean of maximum temperature, daily mean of minimum temperature, daily mean of rainfall and R.H%, whereas, the relationship was significant with predatory insects. In 2021, a significant relationship with a daily mean of maximum temperature, daily mean of minimum temperature and predatory insects were found. For the effect of plant age, simple correlation showed a positive and significant effect with Age 1 and Age 2 with (r) values were 0.58 and 0.48 respectively, whereas the second season was negative and insignificant with Age 2 and Age 3 and positive insignificant effect with Age 1 . Here, we tested the susceptibility of two wheat varieties to the infested with Aphid density, the highest infestation of aphid species on wheat Misr 3 variety associated with highest total protein (12.2%) and total phenols content (0.95±0.04 mg/gm), whereas, the least infestation by aphid species on wheat Misr 1 variety associated with least total protein and phenols content.