Preseasonal prophylactic treatment with antihistamines suppresses nasal symptoms and expression of histamine H1 receptor mRNA in the nasal mucosa of patients with pollinosis

Abstract

Administration of antihistamines 2-4 weeks before the pollen season showed a greater inhibitory effect on nasal allergy symptoms in patients with seasonal allergic rhinitis. However, the mechanism of slow-onset effects of preseasonal treatment with antihistamines remains unclear. Here, we investigated the effect of preseasonal prophylactic treatment with antihistamines on nasal symptoms and the expression of histamine H₁ receptor (H1R) mRNA of the nasal mucosa in patients with cedar pollen pollinosis. During the peak pollen period, the expression of H1R mRNA in the nasal mucosa and the scores of sneezing and watery rhinorrhea in patients receiving preseasonal prophylactic treatment with antihistamines were significantly suppressed in comparison with those in the patients without treatment. Moreover, there was a significant correlation between the nasal symptoms and the expression of H1R mRNA in both patients with or without preseasonal prophylactic treatment. These findings suggest that preseasonal prophylactic treatment with antihistamines is more effective than on-seasonal administration to patients with pollinosis in reducing nasal symptoms during the peak pollen period by suppressing H1R gene expression in the nasal mucosa.

Involvement of Protein Kinase Cδ/Extracellular Signal-regulated Kinase/Poly(ADP-ribose) Polymerase-1 (PARP-1) Signaling Pathway in Histamine-induced Up-regulation of Histamine H1 Receptor Gene Expression in HeLa Cells

“…The strength of H1R signaling depends on the H1R expression level (8). Our recent studies have demonstrated that the level of H1R gene expression is strongly correlated with the severity of allergic symptoms in model rats and patients with pollinosis (9,10), and compounds that suppress H1R gene up-regulation alleviate allergic symptoms (11)(12)(13)(14)(15)(16). These findings suggest that the H1R gene is an allergy-sensitive gene, i.e.…”

Transcriptional microarray analysis reveals suppression of histamine signaling by Kujin alleviates allergic symptoms through down-regulation of FAT10 expression

“…We have demonstrated that repeated pretreatment of antihistamines 1-5 weeks before provocation were more effective in suppressing both nasal symptoms and the expression of H1R mRNA in the nasal mucosa of the TDI-sensitized rats than their single administration [9]. Furthermore, we have shown that there was a significant correlation between the nasal symptoms and the expression level of H1R mRNA in patients with pollinosis [10].…”

“…Many studies have shown that activation of H1R by histamine is responsible for the symptoms of allergic rhinitis. Our recent data suggest that H1R gene is an allergic diseases-sensitive gene whose expression level affects severity of allergic symptoms [9,10], and compounds that suppress H1R gene expression should be good therapeutics [11][12][13]. The allergic reaction is also characterized by a disruption of Th1/Th2 balance toward a pronounced Th2 profile.…”

Disruption of Heat Shock Protein 90 (Hsp90)-Protein Kinase Cδ (PKCδ) Interaction by (−)-Maackiain Suppresses Histamine H1 Receptor Gene Transcription in HeLa Cells

“…Histamine is a major chemical mediator of allergic reactions, and its action is mainly mediated through the activation of histamine H 1 receptor (H1R). 4 As a consequence, antihistamines are a widely employed first-line treatment for nasal symptoms of pollinosis. Recently, we reported that the H1R gene expression strongly correlated with the severity of allergic symptoms in toluene-2,4-diisocyanate (TDI)-sensitized rats, a commonly used allergy model, and patients with Japanese cedar pollinosis (3,4).…”

“…4 As a consequence, antihistamines are a widely employed first-line treatment for nasal symptoms of pollinosis. Recently, we reported that the H1R gene expression strongly correlated with the severity of allergic symptoms in toluene-2,4-diisocyanate (TDI)-sensitized rats, a commonly used allergy model, and patients with Japanese cedar pollinosis (3,4). We also demonstrated that compounds that suppress up-regulation of H1R gene expression alleviate allergy symptoms (5)(6)(7)(8).…”