Prescriptions for category D and X drugs during pregnancy in Taiwan: a population-based study

Chen, Yi Hua; Lin, Herng Ching; Chung, Shiu-Dong

doi:10.1002/pds.3599

Cited by 5 publications

(5 citation statements)

References 32 publications

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“…Past studies have demonstrated that physicians and pregnant women should pay particular attention to the safety and adverse effects of drugs and herbs during pregnancy [ 34 , 35 ]. We found that 81.7% of patients received their first CHM prescription during the first trimester.…”

Section: Discussionmentioning

confidence: 99%

Prescription patterns and factors influencing the use of Chinese herbal medicine among pregnant women in Taiwan: a population-based retrospective study

Wen

Chang

Shen

et al. 2020

BMC Complement Med Ther

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Background The use of Chinese herbal medicine (CHM) has been widely promoted as a natural and safe way to treat illness during pregnancy. However, prescription patterns and factors influencing its use are largely unknown. Therefore, we conducted a population-based study to address these questions. Methods Pregnant women aged 18–50 years were selected from Taiwan’s National Health Insurance Research Database between 2001 to 2011. CHM prescriptions and diagnostic records were collected. Demographic data and pre-existing diseases were compared between CHM users and non-users. A multivariate logistic regression analysis was performed to identify possible factors influencing the use of CHM during pregnancy. Results A total of 81,873 eligible prescription records were identified, and 16,553 pregnant women were prescribed CHM during pregnancy, yielding a CHM prescription rate of 20.2%. The three most frequently used herbs were Scutellariae Radix (Huang Qin) (4.4%), Eucommiae cortex (Du Zhong) (2.5%), and Atractylodes Rhizome (Bai Zhu) (2.4%). The most frequently used herbal formulae were Dang-Guei-Shao-Yao-San (4.1%), Jia-Wei-Xiao-Yao-San (3.5%), and Xiang-Sha-Liu-Jun-Zi-Tang (2.6%). Multivariate logistic regression revealed that subjects with an older age, a university education, a pre-pregnancy history of CHM use, asthma, chronic renal disease, and cardiac valvular disease and living in a residential area other than northern Taiwan had an increase in adjusted odds ratio for CHM use during pregnancy. Conclusions In this population-based study, we found that demographic factors and pre-existing diseases were associated with the use of CHM among pregnant women. It is worth noting that Leonuri Herba (Yi Mu Cao) and Shao-Fu-Zhu-Yu-Tang should be used with caution in the first trimester. Further research is needed to explore the safety and effectiveness of the use of CHM in pregnant women.

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Section: Discussionmentioning

confidence: 99%

Prescription patterns and factors influencing the use of Chinese herbal medicine among pregnant women in Taiwan: a population-based retrospective study

Wen

Chang

Shen

et al. 2020

BMC Complement Med Ther

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“…(3) Moreover, pregnant women use medications from across all the Federal Drug Administration (FDA) drug classification risk categories. In a review of more than 150 thousand pregnancies, Andrade et al found that while the majority (78%) of pregnant women are exposed to either class B or C drug, 1.1% and 3.4 % are exposed to either a class X or D. (4–6) (Class D indicates that there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks; whereas class X indicates that studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits. ).…”

Section: Medications Use In Pregnancymentioning

confidence: 99%

“…nausea and vomiting of pregnancy, gestational diabetes, cholestasis of pregnancy, preeclampsia, etc…) that require pharmacotherapy. (4, 6, 8–13). For example, while less than 1% of pregnant women used an antidepressant in the late 1980’s, it is estimated that almost 10% of pregnant women are currently prescribed psychotropic medicines, with antidepressants being the most common ones (7.5%).…”

Section: Medications Use In Pregnancymentioning

confidence: 99%

Epidemiology of medications use in pregnancy

Ayad

Costantine

2015

Seminars in Perinatology

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The use of prescribed and over-the-counter medications in pregnancy is on the rise. Many women become pregnant at an older age and with pre-existing medical conditions that require pharmacotherapy. In addition, pregnancy is associated with profound changes in the physiology of virtually every organ in the body, which affect medications’ pharmacokinetics and pharmacodynamics. Despite all of these, pregnant women are still considered therapeutic orphans as the majority of current therapeutics were never studied in pregnancy. The goals of this review are to synthesize the available information regarding the epidemiology of medications use and the state of drug research in pregnancy, in an effort to highlight the need for pharmacologic research in pregnancy.

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“…49,50 Gebelere sıkça reçetelenen bir diğer ilaç ise normal koşullarda gebelikte kontrendike olduğu bilinen progesterondur (gebelik kategorisi "D"). 51 Bununla birlikte, progesteron gebeliğin sağlıklı ilerlemesi için gerekli bir hormondur. Bu sebeple düşük riski taşıyan gebelere reçete edilebilmektedir (bu endikasyon özelinde kullanılabilen progesteronun gebelik kategorisi çeşitli kaynaklarda değişebilmekle birlikte "B" kabul edilmektedir).…”

Section: Sat Döllenmeunclassified

The Contribution of Community Pharmacists to the Rational Management of Drug Use in Pregnancy: Practical Recommendations

Kirmizi¹,

Bayram²,

Tamirci³

et al. 2018

J Lit Pharm Sci

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Prescriptions for category D and X drugs during pregnancy in Taiwan: a population-based study

Abstract: Our study found that the physicians obviously reduced the use of category D and X drugs for women after becoming aware that they were pregnant.

Cited by 5 publications

References 32 publications

Prescription patterns and factors influencing the use of Chinese herbal medicine among pregnant women in Taiwan: a population-based retrospective study

Prescription patterns and factors influencing the use of Chinese herbal medicine among pregnant women in Taiwan: a population-based retrospective study

Epidemiology of medications use in pregnancy

The Contribution of Community Pharmacists to the Rational Management of Drug Use in Pregnancy: Practical Recommendations

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