Prescription system to calculate precise doses of Chinese herbal medicine to avoid toxic effects

Lin, Dai-Ying; Huang, W.; Lin, Yu-Chuan; Hung, Hsin Yi; Ou, Shi‐Chen; Chang, Chin-Wei; Lin, Hui Wen; Lin, Ting-Yen; Chang, Chiung‐Fang; Hung, Hui-Chun; Huang, Sheng‐Teng

doi:10.1016/j.heliyon.2023.e16612

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…In addition to the direct detection of raw materials, SERS has a capacity to distinguish the principal constituents of the same CHM with different weight ratios of raw materials in their original formulation. 50–52 For example, Huang et al used Ag colloid-based SERS technology to study the chemical constituents of two Huoxue Huayu decoctions. 53 The two decoctions were made from 12 same herbs with different weight ratios.…”

Section: Raw Materials Identificationmentioning

confidence: 99%

Surface-enhanced Raman spectroscopy as a powerful method for the analysis of Chinese herbal medicines

Xu,

Song,

et al. 2024

Analyst

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Section: Raw Materials Identificationmentioning

confidence: 99%

Surface-enhanced Raman spectroscopy as a powerful method for the analysis of Chinese herbal medicines

Xu,

Song,

et al. 2024

Analyst

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“…Further, a formulation containing a mixture of at least two types of herbs in precise proportions [ 158 , 159 ] has been commonly prescribed for treating numerous symptoms, including amnesia, cramping, convulsions, disorientation, insomnia, and unconsciousness, suggesting the association of synergism [ 160 , 161 ]. Consequently, the development of evidence-based TCM and the identification of novel lead compounds and molecular scaffolds are deemed challenging tasks.…”

Section: Limitations and Future Prospectsmentioning

confidence: 99%

Oxidative Stress in Spinocerebellar Ataxia Type 3 and Its Attenuation by Herbal Remedies in Traditional Chinese Medicine: A Systematic Review

Mohd Hisam,

Wong

2024

Antioxidants

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Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant neurodegenerative disorder that gives rise to motor incoordination and progressive functional disabilities. Although pharmacological interventions have revealed promising prospects in the management of SCA3, adverse effects may become unbearable. The use of herbal remedies in traditional Chinese medicine (TCM) may serve as potential alternative medicines to delay the progression of the disease. This systematic review is intended to identify, appraise, and summarize the findings of studies pertaining to the therapeutic roles of herbal remedies in TCM targeting oxidative stress in the management of SCA3. A literature search for relevant articles published from 1 January 2013 to 30 June 2023 in three databases, namely PubMed, Web of Science, and Scopus, was carried out according to the procedures of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A total of ten preclinical studies met the inclusion criteria of the systematic review. We recognized the therapeutic potential of Brassica napus, Codonopsis pilosula, Curcuma sp., Gardenia jasminoides, Gastrodia elata, Ginkgo biloba, Glycyrrhiza inflata, Hericium erinaceus, Hyptis sp., Paeonia lactiflora, Panax ginseng, Poria cocos, Pueraria lobata, Rehmannia glutinosa, and Scrophularia ningpoensis. We identified the types of preclinical models expressing polyglutamine (polyQ) expanded mutant protein (mATXN3), inducers of oxidative stress that mimic the SCA3 pathogenesis, and effective doses of the herbal remedies. The modes of action contributing to the attenuation of oxidative stress are activation of antioxidant pathways, ubiquitin–proteasome system and autophagy, regulation of apoptosis, proinflammatory signaling pathway and chaperones, regulation of mitochondrial function and biogenesis, and restoration of neurotransmission and synaptic plasticity. In conclusion, herbal remedies in TCM may possibly delay the progression of SCA3, therefore providing justification for clinical trials.

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Herbal Medicine Dosage Standardisation

Busia

2024

Journal of Herbal Medicine

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Prescription system to calculate precise doses of Chinese herbal medicine to avoid toxic effects

Cited by 3 publications

References 29 publications

Surface-enhanced Raman spectroscopy as a powerful method for the analysis of Chinese herbal medicines

Surface-enhanced Raman spectroscopy as a powerful method for the analysis of Chinese herbal medicines

Oxidative Stress in Spinocerebellar Ataxia Type 3 and Its Attenuation by Herbal Remedies in Traditional Chinese Medicine: A Systematic Review

Herbal Medicine Dosage Standardisation

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