Prescription pattern of antiepileptic drugs in indoor patients at tertiary care hospital in Haryana, India

Narwat, Arvind; Sharma, Vivek

doi:10.18203/2319-2003.ijbcp20180670

Cited by 4 publications

(2 citation statements)

References 4 publications

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“…Adverse effects of antiepileptic drugs (AEDs) remain a major cause of morbidity and mortality in the course of treatment of epilepsy and hence considerably impact the quality of life of people with epilepsy, perhaps as much as the seizure burden. The exact incidence of adverse effects of AEDs has not been established as most people with epilepsy are treated as outpatients and are not hospitalized for either the epilepsy or for the adverse effects [1]. The exact incidence of adverse effects of AEDs has not been adequately documented for various reasons.…”

Section: Introductionmentioning

confidence: 99%

Drug-Induced Cutaneous Reactions: A Pharmacovigilance Study

DUA,

NARWAT,

GOYAL

2024

Int J Pharm Pharm Sci

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Objective: Drug-induced cutaneous reactions are common problem in our country and can range from simple rash to severe reactions. Early recognition of these reactions enables early identification and withdrawal of offending drugs, thereby reducing morbidity and mortality. So present study aimed to assess clinical pattern of drug-induced cutaneous reactions in Dermatology OPD. Methods: This study was an open, non-comparative, non-interventional, observational study conducted on patients visiting dermatology department to see the clinical pattern of drug-induced cutaneous reactions. A total of 60 patients with suspected cutaneous adverse drug reactions were recruited. A detailed physical examination was done by a physician, including drug intake during 3 w preceding reactions and type of drug reactions. Results: Most frequently reported cutaneous drug reactions were Stevens-Johnson Syndrome (23%), Maculopapular rash (18%) Toxic Epidermal Necrolysis (15%) and were caused by antiepileptic drugs in 21(35%) patients, followed by antibiotics in 17(28.33%) cases, NSAID’s in 7(11.6%) cases, antitubercular drugs in 3(5%) and antiretroviral drugs in 3(5%) cases. A high proportioned of these reactions (50%) were moderate (31%) of these were severe because they require hospitalisation or increased the duration of stay in hospital or were life-threatening in (1%). Principal offending drug was phenytoin. Conclusion: A good knowledge of ADRs, a careful history taking and watchful approach while prescribing of drugs can prevent many of adverse drug reactions. These facts justify the development of an intensive programme of pharmacovigilance.

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Section: Introductionmentioning

confidence: 99%

Drug-Induced Cutaneous Reactions: A Pharmacovigilance Study

DUA,

NARWAT,

GOYAL

2024

Int J Pharm Pharm Sci

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“…[2,3] Moreover, polytherapy is required and recommended in patients suffering from epilepsy of multiple seizure types and are in refractory disease state. [4] Many of the above antiepileptic drugs also find application in the treatment of neuropathic pain, migraine and psychiatric disorders. [5] Thus the utility and prescribing pattern of antiepileptic drugs has enormously widened with large number of patient population.…”

Section: Introductionmentioning

confidence: 99%

Prescription Pattern analysis and utilization of antiepileptic drugs in a tertiary care hospital in Kanchipuram

2022

pnr

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Background: People suffering from epilepsy requires a long period of treatment and regular monitoring. Extensive use of antiepileptic drugs warrants critical monitoring to suggest appropriate clinical use and safety considerations. Objectives: The study was aimed to analyse the prescription pattern of antiepileptic drugs in a tertiary care hospital in Kanchipuram. Methodology: This was a prospective, observational study conducted in outpatient departments at Meenakshi medical college Hospital and Research institute. Institutional ethical clearance was obtained. Results: Monotherapy were prescribed among 69.9% of patients and 30.08% of patients received polytherapy. levetiracetam (23.8%) was the most prescribed drug followed by benzodiazepines (16.8%), hydantoin drugs such as phenytoin, fosphenytoin (11.5%), valproic acid(10.6%) and iminostilbenes such as carbamazepine and oxcarbazepine(5.3%).AEDs were more prescribed only for seizure disorder (79%) than any other disease conditions. Conclusion: A shift from the use of conventional antiepileptic drugs to the newer AED's was observed, which dominated the pharmacotherapy of epileptic seizures. This would form a part of pharmacoepidemiology and will update the treatment guidelines benefitting the physicians regarding optimal use of antiepileptic drugs.

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Drug Utilization Study in Epilepsy in A Tertiary Care Hospital

Chandrarathna

Parida

Manju

et al. 2019

Biomed. Pharmacol. J.

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Treatment of epilepsy is quite challenging as it requires the antiepileptic drugs to be taken for a long duration, sometimes throughout the lifetime of the patient. But such chronic drug intake results in adverse effects, drug interactions and added economic and emotional distress to the patients. It is therefore of utmost importance to analyze the pattern of prescription of antiepileptic drugs, the concurrent medications in epilepsy. The present study was conducted to collect, assess and understand the above data and also to analyze the rationality and correctness of prescription using the WHO prescription indicators. A total of 100 case records of patients diagnosed with epilepsy was analyzed and the data was recorded. We have total 34 children and 66 adult patients in our study. Generalized tonic-clonic seizures was the common type of seizure. Phenytoin was the most commonly prescribed antiepileptic drug. 1/3rd of the patients needed more than one drug for adequate seizure control and the most common add on drug was levetiracetam. Also, the average number of drugs prescribed to the patients was 6 which included drugs given for concomitant illnesses as well. A total of 561 medicines were prescribed which included the drugs prescribed for concomitant illnesses as well. Average number of medicines per prescription was 6. Prescription by generic name was seen in 42% of the cases. An injection was prescribed in 66% of the prescriptions. An antibiotic was encountered in 38% of the prescriptions. Most of the epileptic patients are subjected to polypharmacy which puts them at a higher risk of side effects, drug interactions and financial burden. Physicians should minimize the use of drugs and look into the rationality of each prescription.

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Prescription pattern of antiepileptic drugs in indoor patients at tertiary care hospital in Haryana, India

Cited by 4 publications

References 4 publications

Drug-Induced Cutaneous Reactions: A Pharmacovigilance Study

Drug-Induced Cutaneous Reactions: A Pharmacovigilance Study

Prescription Pattern analysis and utilization of antiepileptic drugs in a tertiary care hospital in Kanchipuram

Drug Utilization Study in Epilepsy in A Tertiary Care Hospital

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