Prescription Pattern of Anti-Hypertensive Drugs in Adherence to JNC- 7 Guidelines

Murti, Krishna; Khan, Moharram A.; Dey, Akalanka; Sethi, Manoj; Das, Pradeep; Pandey, Krishna

doi:10.3844/ajptsp.2015.27.31

Cited by 11 publications

(23 citation statements)

References 11 publications

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“…The above pattern is analogous to studies conducted by (Jhaj et al; Malhotra et al; Kothari et al; Murti et al) in India. [32][33][34][35] However the above pattern is anomalous to other studies conducted by (Tiwari et al; Surapaneni et al) in India, Pittrow et al in Germany and (Lee et al, in China have reported higher prevalence of hypertension in females than in males. 18,26,29,30 This study also reveals that hypertension is more prevalent in elderly patients belonging to age group 40-60 or more.…”

Section: Discussioncontrasting

confidence: 54%

An assessment of antihypertensive drug prescription patterns and adherence to joint national committee-8 hypertension treatment guidelines among hypertensive patients attending a tertiary care teaching hospital

Romday¹,

Gupta

Bhambani

2016

Int J Res Med Sci

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Background:The new guidelines issued by the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure (JNC-8) emphasize that aggressive blood pressure (BP) control is essential to reducing morbidity and mortality. Patient non-adherence is a serious obstacle to the effective treatment of many acute and chronic disorders. Successful treatment and outcome of a chronic disease such as hypertension depend on many factors, including resources (e.g., funds, space, and people), avoidance of serious adverse events, patient adherence with treatment plans, and the availability of effective therapies. The aim of this study is to assess the antihypertensive drug prescription patterns and adherence to joint national committee (JNC-8) hypertension (HT) treatment recommendations among hypertensive patients attending a tertiary care teaching hospital. Methods: An observational and cross-sectional prospective prescription audit study was carried over a period of 1 year in ambulatory patients attending medicine OPD. A total of 500 prescriptions prescribed to diagnose HT were analyzed. Drug prescription patterns, and their adherence to JNC-8 report was assessed. Results: Out of 500 patients, 299 (59.8%) were male and 201 (40.2%) were female. Mean age of male and female patients were found to be 57.68±15.32 and 61.29±12.65 years respectively. As per present study, most of the physicians prescribed single drug (monotherapy, 34.6%) to control BP followed by two-drug combination (18.4%), three-drug combination (11.8%) and four-drug combination (3%). Two drugs regimen was prescribed in 18.4% of the hypertensive patients. Angiotensin receptor blocker + diuretic combination (4.4%) was mostly used in two drug combination therapy followed by Angiotensin receptor blockers + Diuretics (3.6%) and Calcium channel blocker + ACEIs combination (2.6%). No combination of ACEIs + ARBs was prescribed in any prescription. The overall rate of adherence was 16.5 % (Pre-hypertension); 87.90% (Stage 1 hypertension); and 68.20% (Stage 2 hypertension). Conclusions:In conclusion, present study demonstrated that physicians are not completely adhering to standard guidelines while treating hypertension with comorbid conditions.

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Section: Discussioncontrasting

confidence: 54%

An assessment of antihypertensive drug prescription patterns and adherence to joint national committee-8 hypertension treatment guidelines among hypertensive patients attending a tertiary care teaching hospital

Romday¹,

Gupta

Bhambani

2016

Int J Res Med Sci

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“…Our report might relate to the recent report of the high prevalence of hypertension and obesity among women in Nigeria [23]. The results indicated that most of the patients were in the age range of 41-60, which is consistent with the study by Krishna et al [22]. This shows that CVDs and diabetes affect people in the most productive years of their lives.…”

Section: Discussionsupporting

confidence: 92%

“…There was a high prescription of CCB, particularly amlodipine in FCT district hospitals. This was reported in some other studies [11,12,39,40] while CCB has been reported as least prescribed [22,41]. Agents that act on the renin-angiotensin system hold a good share of the prescription, with Lisinopril and Telmisartan leading in the class similar to other studies [15,41].…”

Section: Discussionsupporting

confidence: 72%

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Prescription Pattern of Cardiovascular and/or Antidiabetic Drugs in Abuja District Hospitals

Osuafor¹,

Ukwe²,

Okonta³

2019

Int J Pharm Pharm Sci

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Objective:The study aimed to describe the prescription pattern of cardiovascular and/or anti-diabetic drugs and adherence to the World Health Organization (WHO) prescribing indicators in Abuja District Hospitals.Methods: This descriptive retrospective study was carried out in Asokoro and Maitama District Hospitals Abuja. One thousand and nine prescriptions that contained a cardiovascular drug (CVD) and/or anti-diabetic drug issued between June 2017 and May 2018 from the Medical Outpatient Department were analyzed. Data were collected from the pharmacy electronic database, prescription pattern and adherence to WHO prescribing indicators were assessed. The analysis was done using descriptive statistics. Results were presented as percentages, means, and standard deviations. Results:The frequency of treatment was higher among women (58.8%) and the age group of 41-60 (54.8%). The average number of drugs prescribed was 3.3±1.6: the percentage of drugs prescribed in generic was (64%) and (78.8%) were from the Essential Drug List (EDL). Calcium Channel Blockers (CCB, 71.7%) and Biguanides (B, 92.4%) were the most prescribed CVD and anti-diabetic drug. The majority of the CVD (74.5%) and diabetes (63.6%) patients were on combination therapy. The most frequent CVD combination was CCB plus Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor Blockers (29.7%). Compared to men, the proportion of females taking one or more CVD (61.3%) or antidiabetic (56.4%) was higher. Conclusion:The prescribing indicators are not optimal in Abuja district hospitals. Women received more treatment for cardiovascular and diabetes diseases than men while the age range of 41-60 was more treated than other age groups.

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“…75% were put on multidrug therapy out of which 35% patients were on two drug therapy, 32% of patients on three drug therapy and 08% on four drug therapy. 5 Among the monotherapy category the various hypertensive classes prescribed were CCB's (15%) followed by Diuretics (08%), ARB's (04%) and ACEI (02%) respectively. As a Monotherapy Amlodipine (15%) was the most frequently prescribed drug along with furosemide (08%), telmisartan (02%), losartan (02%), and ramipril (02%).…”

Section: Discussionmentioning

confidence: 99%

Study of Prescribing Pattern of Antihypertensive Drugs and Evaluation of the Prescription with JNC 8 Guidelines in North Karnataka Hospital

Malpani¹,

Waggi²,

Panja³

et al. 2018

IJOPP

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Aim:To conduct a prospective observational study on prescribing pattern of antihypertensive drugs and to evaluate the current practice of antihypertensive drug by comparing with JNC-8 guidelines in north Karnataka hospital. Methods: The study was conducted for a period of 6 months with a sample size of 100 of all the in-patient of age ≥ 18 years of hypertension with or without co-morbidities, including pregnant women and lactating mothers. Results: A total of 100 prescriptions were analysed during the six-month study period. 55% were male while 45% were female. 25% patients received monotherapy while majority of the patient's i.e. 75% were put on multidrug therapy of which, 35% patients on two drug therapy, 32% of patients on three drug therapy and 8% on four drug therapy. The most common drug classes involved in the study were ARBs (17%), BBs (09%) and ACEIs (03%). Our study reveals that without diabetes or CKD (greater than 60 years) 75.60% of patients were compliant with JNC-8 goal (less than 150/90 mmHg) and without diabetes or CKD (less than 60 years) 64.30% of patients were compliant with JNC-8 goal (less than140/90 mmHg). Patients with diabetes and without CKD (all ages) 50% achieved the JNC-8 goal (less than140/90 mmHg) and Patients with CKD or without DM (all ages and races) 60% achieved the JNC-8 goal (less than140/90 mmHg). Conclusion: Calcium channel blockers (Amlodipine) and diuretics (Furosemide) were the drug of choice for hypertensive patients as a single drug and combination drug therapy. As per the JNC 8 guidelines majority of the BP goals were achieved. Our result reveals that antihypertensive medication adherence to JNC 8 guidelines is optimal at the study site.

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Prescription Pattern of Anti-Hypertensive Drugs in Adherence to JNC- 7 Guidelines

Cited by 11 publications

References 11 publications

An assessment of antihypertensive drug prescription patterns and adherence to joint national committee-8 hypertension treatment guidelines among hypertensive patients attending a tertiary care teaching hospital

An assessment of antihypertensive drug prescription patterns and adherence to joint national committee-8 hypertension treatment guidelines among hypertensive patients attending a tertiary care teaching hospital

Prescription Pattern of Cardiovascular and/or Antidiabetic Drugs in Abuja District Hospitals

Study of Prescribing Pattern of Antihypertensive Drugs and Evaluation of the Prescription with JNC 8 Guidelines in North Karnataka Hospital

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