Prescription of cardiovascular drugs in the French ODIN cohort of heart failure patients according to age and type of chronic heart failure

Abstract

In CHF, and despite management by cardiologists particularly interested in CHF and specifically trained to deliver therapeutic patient education, medical prescription differed substantially from guidelines. Age and type of CHF (reduced versus preserved) appeared to be important factors in lack of adherence to guidelines. However, only age influenced mortality; the type of CHF did not affect survival.

Patients with HFpEF and HFrEF have different clinical characteristics but similar prognosis: a retrospective cohort study

“…One of the proposed predictions by Y. Juillière et al was systemic hypertension is more frequently associated with preserved ejection fraction, resulting a higher rate of prescription of CCB. In contrast most of the etiologies in patients with HFrEF are usually IHD [38]. Similar findings were presented in our study, where most of patients with HFpEF took CCB and anticoagulants since hypertension and AF were more prevalent in this group of patients.…”

“…However, CCB are usually indicated for patients with HFpEF [38]. This is further supported by 2016 ESC European heart failure guideline, as indicated amlodipine in HF patients with preserved ejection fraction and ventricular rhythm problem [39].…”

Prevalence and correlates of non-optimal secondary medical prevention in patients with stable coronary artery disease

“…Several variables were associated with non-optimal secondary medical prevention in CAD patients. As previously reported [3,5], advancing age was associated with less adherence to guidelines; similar results have also been reported in other cardiovascular diseases, such as heart failure [17]. The higher proportion of patients with diabetes mellitus and/or hypertension in the group with non-optimal treatment was, at least in part, related to the fact that, according to guidelines, all these patients should receive an ACE inhibitor or an ARB; although the proportion of diabetic or hypertensive patients receiving ACE inhibitors/ARBs actually increased compared with non-diabetic or nonhypertensive counterparts (data not shown), the proportion with respect to guidelines was lower.…”

Sildenafil in heart transplant candidates with pulmonary hypertension

“…Morbimortality remains elevated despite improvements in the therapeutic management of patients with heart failure related to left ventricular systolic dysfunction (LVSD) [1][2][3][4][5]. Heart transplantation is required in some patients, but the low number of heart donors is a major limiting factor preventing the widespread use of this approach.…”