Prescription medication use in persons many years following traumatic brain injury

Yasseen, Baseer; Colantonio, Angela; Ratcliff, Graham

doi:10.1080/02699050802320132

Cited by 28 publications

(29 citation statements)

References 17 publications

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“…Thus, we are unable to separate the changes in sleep that occur in the months and years following TBI. Psychiatric comorbidities 62 and medication use are also prevalent in TBI, 48 potentially exacerbating sleeping difficulties. Future studies are required to investigate how such factors relate to the risk of sleep disturbance.…”

Section: Discussionmentioning

confidence: 99%

“…47 Individuals with TBI tend to use more medications than the general population, including medications that cross the blood-brain barrier, such as antidepressants. 48 The use of medications may thus contribute to sleep deficits observed in those with TBI. Other secondary complications following TBI, such as medical comorbidities, may also contribute to sleeping difficulties.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Sleep Disturbances in Traumatic Brain Injury: A Meta-Analysis

Grima

Ponsford

Rajaratnam

et al. 2016

Journal of Clinical Sleep Medicine

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Study Objectives: Sleep disturbances are frequently reported following traumatic brain injury (TBI); however, the exact disturbances remain unclear. This meta-analysis aimed to characterize sleep disturbance in community dwelling patients with TBI as compared to controls. Methods: Two investigators independently conducted a systematic search of multiple electronic databases from inception to May 27, 2015. Studies were selected if they compared sleep in community dwelling individuals with TBI relative to a control population without head injury. Data were pooled in metaanalysis with outcomes expressed as the standard mean difference (SMD) and 95% confidence interval (CI). The primary outcomes were derived from polysomnography and secondary outcomes were derived from subjective sleep measures. Results: Sixteen studies were included, combining 637 TBI patients and 567 controls, all of whom were community dwelling. Pooled polysomnography data revealed that TBI patients had poorer sleep efficiency (SMD = −0. I NTRO DUCTI O NSleep disturbances are frequently reported following traumatic brain injury (TBI), with over 50% of people experiencing some form of sleep disturbance post TBI.1 Although a large majority of people with TBI generally make a good physical recovery, disrupted sleep can often go untreated, impacting quality of life, impeding rehabilitation and return to pre-injury activities.2-5 Our recent work showed significant interrelationships between daytime sleepiness, daytime fatigue, cognitive impairment, and mood disturbances in TBI. 6 While individuals with TBI are known to report sleep problems, 1 the specific changes to sleep remain poorly characterized.7 Studies have been limited by small sample sizes, with variable and inconsistent findings. [8][9][10][11][12] This makes for a difficult characterization of sleep post TBI. Thus, there is a need to establish the specific aspects of sleep that are most affected post TBI as these have important implications for treatment and rehabilitation. The aim of the current meta-analysis was to characterize both objective sleep disturbances and subjective sleep complaints in individuals with TBI relative to healthy controls. Study outcomes included the comparison of TBI patients to controls across both polysomnography and subjective measures of sleep. It ; Matthew P. Pase, PhD was hypothesized that those with TBI would display widespread objective and subjective sleep deficits as compared to controls without head injury. The present study aimed to summarize current literature, which would identify important avenues for future research. M ETHO DS Study DesignThe search strategy was conducted in accordance with the meta-analysis of observational studies in epidemiology guidelines. 13 Article SearchingOvid Medline, Embase, PsychInfo, Scopus, and the Cochrane Library were systematically searched until May, 27 2015. The search was initially developed by all authors and refined by a librarian at Monash University. The references of recent publications were also hand searc...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sleep Disturbances in Traumatic Brain Injury: A Meta-Analysis

Grima

Ponsford

Rajaratnam

et al. 2016

Journal of Clinical Sleep Medicine

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“…1 Masel and DeWitt have proposed that TBI may initiate an ongoing, possibly lifelong, process that affects multiple organ systems and may cause or accelerate the progression of diseases. 10 Chronic diseases that may be attributed to previous TBI in the literature include epilepsy, 11 gradual decline in cognitive function, 12 Alzheimer's disease, 13 Parkinson's disease, 14 hypopituitarism, 15 metabolic dysfunction, 16 and psychiatric diseases (eg, obsessive-compulsive disorder, anxiety disorder, psychotic disorders, and mood disorders). 17 Furthermore, any damage to the brain usually causes impairment to the vascular system, which supplies blood and nutrients to the cells of the brain.…”

mentioning

confidence: 99%

Patients With Traumatic Brain Injury

Chen

Kang

Lin

2011

Stroke

109

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Background and Purpose-Previous studies have identified an array of morbidities following traumatic brain injury (TBI), including certain neurological disorders. However, no direct evidence has been reported on the link between TBI and stroke. This population-based study was designed to estimate the risk of stroke during a period of 5 years following a TBI, compared with individuals who did not suffer TBI during the same period. Methods-Data

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“…Patients with traumatic brain injury are most often prescribed AEDs for post-traumatic seizures, neurobehavioral disorders, and pain. Up to 26% of TBI patients are prescribed these medications chronically after injury, and AEDs are the most frequently prescribed medications in TBI patients under the age of 65 [6].…”

Section: Antiepileptic Drugs For the Treatment Of Acute Traumatic Bramentioning

confidence: 99%

“…Levetiracetam has been used with increasing frequency due to ease of dosing and its role in post-traumatic seizures is still being defined. One trial comparing the effectiveness of levetiracetam versus phenytoin demonstrated no significant difference between the two medications, although there were increased abnormal findings on EEG compared to phenytoin [6] [13].…”

Section: Aeds and Post-traumatic Seizuresmentioning

confidence: 99%

The Use of Antiepileptic Drugs in Acute Neuropsychiatric Conditions: Focus on Traumatic Brain Injury, Pain, and Alcohol Withdrawal

Nejad

Chuang²,

Hirschberg³

et al. 2014

IJCM

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Antiepileptic drugs (AEDs), have demonstrated efficacy treating a number of acute conditions, encompassing a broad range of symptoms and syndromes, in addition to being first-line treatment for epilepsy. Clinically, since their inception, AEDs have been used off-label for acute and chronic medical conditions, both as primary and as adjuvant therapies. In this review, we describe the observed clinical effectiveness of AEDs across a set of commonly encountered acute conditions in the general hospital: traumatic brain injury, pain, alcohol withdrawal. In describing the individual benefits and usages of specific agents, the applicability of these agents to other common neuropsychiatric conditions may be further explored.

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Prescription medication use in persons many years following traumatic brain injury

Abstract: The research findings indicate a high prevalence of prescription medications in persons with past history of TBI. There is also a high prevalence of anti-convulsants medication use.

Cited by 28 publications

References 17 publications

Sleep Disturbances in Traumatic Brain Injury: A Meta-Analysis

Sleep Disturbances in Traumatic Brain Injury: A Meta-Analysis

Patients With Traumatic Brain Injury

The Use of Antiepileptic Drugs in Acute Neuropsychiatric Conditions: Focus on Traumatic Brain Injury, Pain, and Alcohol Withdrawal

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