Prescription Design for Total Parenteral Nutrition for HPN (V)-Effects of Sodium Bisulfate and Saccharides on Residual Insulin Ratio in High-Calorie Infusions-.

Kimura, Michio; Ichikawa, Etsuko; Ishii, Norie; Mori, Hiromi; Yamazaki, Futoshi

doi:10.5649/jjphcs.30.43

Jpn. J. Pharm. Health Care Sci.

2004

DOI: 10.5649/jjphcs.30.43

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Prescription Design for Total Parenteral Nutrition for HPN (V)-Effects of Sodium Bisulfate and Saccharides on Residual Insulin Ratio in High-Calorie Infusions-.

Michio Kimura¹,

Etsuko Ichikawa²,

Norie Ishii³

et al.

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Cited by 4 publications

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Investigation into the Establishment of Indicators for Pharmaceutical Intervention in Cancer Pharmacotherapy

Kimura

2016

YAKUGAKU ZASSHI

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The present study was conducted to establish pharmaceutical intervention guidelines to enable hospital pharmacists to provide optimal pharmacotherapy to cancer patients. Many patients who use oral anticancer agents showed favorable drug compliance but insu‹cient drug adherence. It was demonstrated that in order to improve drug adherence, it is important to conduct interventions tailored to the patients' conditions so as to encourage interest in their medications, as well as to gain their understanding on the necessity and the side eŠects of their medications. In adjuvant chemotherapy with tegafur/gimeracil/oteracil potassium (S-1) following surgery for stomach cancer, a serum albumin value ＜3.5 g/ dL and a creatinine clearance value ＜80 mL/min were found to signiˆcantly aŠect S-1 dose reduction or termination of the S-1 intake due to side eŠects. Furthermore, patients for whom treatment was discontinued or dosage was reduced demonstrated a large reduction in body mass index. When adding insulin to an at-home high-calorie infusion, the insulin retention rate decreased when the number of grams of sugar level per 1 g of sodium bisulˆte in the infusion (G/g) was  364.6, whereas the insulin retention rate did not decrease when G/g was  466.0. Ourˆndings in the present study can serve as highly useful guidelines when pharmacists working in clinical settings conduct pharmaceutical interventions in pharmacotherapy for cancer.

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Investigation into the Establishment of Indicators for Pharmaceutical Intervention in Cancer Pharmacotherapy

Kimura

2016

YAKUGAKU ZASSHI

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Stability of Insulin in Total Parenteral Nutrition Solutions

Kumagai¹,

Kihira

Fujimura

et al. 2020

YAKUGAKU ZASSHI

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Elneopa NF No. 1 and No. 2 infusions are complete parenteral nutrition solutions packaged as four-chambered bags. They have been used for home parenteral nutrition, with insulin injected into the bags for patients whose blood glucose becomes elevated. In this study, the stability of insulin in No. 1 and No. 2 bags was investigated. The quantity of insulin in Elneopa NF No. 2 was signiˆcantly lower than that in Elneopa NF No. 1. When insulin was injected into the upper chamber of either product, decreases in insulin levels were not observed. In contrast, the levels of insulin injected into the lower chamber of both products signiˆcantly decreased, with a larger diŠerence in Elneopa NF No. 2. As the amino acid content is diŠerent between No. 1 and No. 2, amino acids may be considered a potential cause for the degradation of insulin in the bags. In addition, decreases in insulin levels were observed as the solutions passed through infusion sets just after ‰ushing began, with both Elneopa NF No. 1 and No. 2. In conclusion, the concentration of insulin injected into the Elneopa infusion bags decreases, especially in No. 2 bags, and insulin is absorbed by the infusion sets.

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Effects of Ingredients and pH of Intravenous Solutions on Stability of Insulin

Kohno¹,

Izumi²,

Toyoda³

2010

Jpn. J. Pharm. Health Care Sci.

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Prescription Design for Total Parenteral Nutrition for HPN (V)-Effects of Sodium Bisulfate and Saccharides on Residual Insulin Ratio in High-Calorie Infusions-.

Cited by 4 publications

References 0 publications

Investigation into the Establishment of Indicators for Pharmaceutical Intervention in Cancer Pharmacotherapy

Investigation into the Establishment of Indicators for Pharmaceutical Intervention in Cancer Pharmacotherapy

Stability of Insulin in Total Parenteral Nutrition Solutions

Effects of Ingredients and pH of Intravenous Solutions on Stability of Insulin

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