Prescribing pattern of Antihypertensive, Anti-Diabetic, Hypolipidaemic and Anti-Obesity Drugs in Diabetic Nephropathy

Abstract

Objective: The Purpose of this study is to evaluate prescribing pattern of drugs to prevent progression of nephropathy in patients of diabetes in a tertiary care hospital. Materials and Methods: It was conducted in a tertiary care hospital, written informed consent was taken from those patients, who fulfilled study criteria and study sample included type 2 diabetic nephropathy outdoor patients who aged more than 40 years who were in stage of micro albuminuria (stage 3 diabetic nephropathy), details like sex, duration of illness, on-going treatment concurrent medicines were recorded in predesigned and pretested case record forms, these data were subjected to analysis using descriptive methods, Microsoft excel was used for data entry and descriptive analysis. A total of 100 patients were included in the study. A written permission has been obtained from Institutional Ethics Committee for the conduct of the study. Results: In the present study there were 100 patients, of whom 63 were males and 37 were females, majority of patients have diabetes for more than 20 years, all patients received anti-hypertensive, anti-diabetic and hypolipidaemic drugs. Among antihypertensive drugs, ACE inhibitors are prescribed most followed by diuretics and calcium channel blockers, among ACE inhibitors; Enalapril and Ramipril were prescribed most. Insulin was prescribed in 50% of patients and Glimepiride was the most common sulfonylurea prescribed. Statins were prescribed most among hypolipidaemic drugs; orlistat was prescribed only for 5% of patients. Majority of the patients were advised by physician regarding regular exercise, protein restricted diet, salt restriction, avoidance of cigarette smoking and weight reduction. Conclusion: Our study concluded that prescribing pattern of drugs in diabetic nephropathy was as per current practices and recommendations of guidelines. The pattern of drug use was to achieve better control of all the risk factors which are involved in progression of nephropathy. Further large scale and more detailed study, which includes sample from government setup and private clinics, is recommended to confirm our findings