Prescribing Pattern of Anti-Diabetic Drugs for Type 2 Diabetic Patients in a Tertiary Care Hospital

Abstract

Introduction: Diabetes mellitus (DM), particularly Type 2 DM is now recognized as a major chronic public health problem throughout the world. Different anti-diabetic agents, oral or injectable are used to regulate patients’ glycemic status as monotherapy or in combination.
 Objectives: To observe the prescribingpattern ofanti-diabetic agents and to collect demographic and disease details of type 2 DM patients.
 Materials and Methods: This descriptive cross-sectional study was conducted from January to August 2017 in the outpatient department of Border Guard Hospital, Pilkhana; a tertiary level hospital in Dhaka. The study enrolled 172 type 2 diabetic patients purposively on specified criteria. Demographic data,drug prescribing pattern, disease pattern were collected by an interview and from patients’ prescriptions.
 Results: Among 172 respondents,70 (40.70%) were male and 102 (59.30%) were female. The mean age of patients was 54.21±10.09 years. Eighty seven (50.58%) patients were either overweight or obese. Eighty two (47.67%) patients had family history of DM. Majority of patients (84.89%) had duration of diabetes >5 years and 84 (48.84%) patients had co-morbidities. Majority of the patients 135(78.49%) were prescribed oral drugs either alone or in combination. Among them 83 (63.48%) patients were prescribed oral monotherapy and 52(38.52%) patients were prescribed oral combination therapy. Metformin was the most prescribed oral anti-diabetic drug as monothearpy (71.08%). Among combined anti-diabetic drugsbased on class, metformin+Dipeptidyl peptidase 4 inhibitors(DPP4i) (36.11%), combination was the most commonly prescribed combination. The findings can lead to select the formulation and combination of anti-diabetic drugs in this part of the world for developing & marketing a new anti-diabetic drug.
 Conclusion: Metformin was the most commonly prescribed drug both as monotherapy as well as combination therapy and monotherapy was predominant over combination therapy.
 Journal of Armed Forces Medical College Bangladesh Vol.14 (2) 2018: 139-143

Prescribing patterns of antidiabetic drugs and glycaemic control in type 2 diabetes patients visiting tertiary care hospital based in Karachi, Pakistan

“…11 In another study conducted in Dhaka Bangladesh, 84% of the participants had a history of less than five years of diabetes. 19 This could mean that there is still a lack of awareness regarding diabetes and its treatment in our country as compared to the neighbouring countries as the patients do not present to the doctors immediately after the diagnosis. 11 The mean HbA1c reported in our study was 7.4±1.6.…”

“…11 In another study conducted in Dhaka, Metformin and DPP4i combination was the most commonly prescribed combination. 19 The common prescription of Metformin is because it is inexpensive, effective, and shows fewer adverse effects. It shows great efficacy when used as a monotherapy producing good glycaemic and weight control with rare events of hypoglycaemia and cardiovascular mortality.…”