Prescribing for children – taste and palatability affect adherence to antibiotics: a review

Baguley, Dave; Lim, Emma; Bevan, Amanda; Pallet, Ann; Faust, Saul N

doi:10.1136/archdischild-2011-300909

Cited by 127 publications

(101 citation statements)

References 35 publications

(56 reference statements)

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“…In addition, a vehicle provides greater stability of the formulation [50]. Access to safe and palatable pediatric formulations and its rational use must remain a major goal in health development worldwide [47], and may have a substantial effect on child morbidity [28].…”

Section: Discussionmentioning

confidence: 99%

“…Taste preferences vary significantly between cultures, so it's necessary to invest in local studies to develop pleasant pediatric formulations for different populations [28]. Evaluation of the most appropriate flavors for different age groups and drugs must be performed carefully so that the arbitrary choice of flavoring does not limit the acceptance of the medication.…”

Section: Introductionmentioning

confidence: 99%

“…Sensory analysis is a stage of product development that analyzes and interprets the reactions produced by its features. Ideally should be performed whenever a new formulation is introduced in a given context [28][29][30].…”

Section: Introductionmentioning

confidence: 99%

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Taste acceptance of Captopril and Furosemide Extemporaneous Oral Pediatric Formulations among Hospitalized Children

Mdsg¹,

Garruti²,

Laa³

et al. 2016

J Pharma Care Health Sys

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Many pediatric patients require medications that are not available in age appropriate formulations, especially those with cardiovascular diseases. The use of a suitable vehicle is critical for the preparation of extemporaneous formulations with the expected effect. Considering that palatability is essential to treatment adherence in children, we analyzed the acceptance of extemporaneous formulations of Captopril and Furosemide prepared using a developed vehicle in three flavors: neutral, strawberry and mint. Formulations were administered to hospitalized pediatric patients as prescribed. Acceptance was evaluated through the guardians using the hedonic scale and compared with the researcher's observation. Formulations in neutral and strawberry flavors were considered acceptable for both drugs. Correlation between results from both methods was moderate for Captopril and absent for Furosemide. Neutral taste results showed that the addition of flavoring agents did not improve acceptance. Since it is recommended to avoid components in formulations for infants and newborns, unless strictly necessary, it is important to identify excipients that are dispensable.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Taste acceptance of Captopril and Furosemide Extemporaneous Oral Pediatric Formulations among Hospitalized Children

Mdsg¹,

Garruti²,

Laa³

et al. 2016

J Pharma Care Health Sys

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show abstract

“…Sefalosporinlerin tatları çocukların oral alımına uygundur. Tat olarak çocuklar tarafından alımları iyi olanlar sefaklor, sefdinir, sefaleksin iken, sefuroksim-aksetilin çocuklar tarafından kabulü daha zordur (4) . Parenteral kullanılanların yarı ömürleri penisiline göre daha uzundur.…”

Section: Günümüzde Sefalosporinler Ve Antibiyotik Direnciunclassified

Cephalosporin Antibiotics and Antibiotic Rezistance in Three Decades

Yıldız¹,

Varkal²,

Ünüvar³

2015

Cocuk Dergisi

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“…Extemporaneous formulations are a common workaround for the lack of commercially available preparations, but concerns regarding lack of dose accuracy, stability, and consistency in preparation present difficulties for both practitioners and caregivers (1). From the pediatricians' perspective, the availability of easy to swallow and palatable formulations can mean the difference between treatment success and failure (2). The age at which children are able to swallow tablets or capsules varies widely, but is generally expected at approximately age 7 and varies with tablet and capsule size.…”

Section: Introductionmentioning

confidence: 99%

A Report from the Pediatric Formulations Task Force: Perspectives on the State of Child-Friendly Oral Dosage Forms

Zajicek

Fossler

Barrett

et al. 2013

AAPS J

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Abstract. Despite the fact that a significant percentage of the population is unable to swallow tablets and capsules, these dosage forms continue to be the default standard. These oral formulations fail many patients, especially children, because of large tablet or capsule size, poor palatability, and lack of correct dosage strength. The clinical result is often lack of adherence and therapeutic failure. The American Association of Pharmaceutical Scientists formed a Pediatric Formulations Task Force, consisting of members with various areas of expertise including pediatrics, formulation development, clinical pharmacology, and regulatory science, in order to identify pediatric, manufacturing, and regulatory issues and areas of needed research and regulatory guidance. Dosage form and palatability standards for all pediatric ages, relative bioavailability requirements, and small batch manufacturing capabilities and creation of a viable economic model were identified as particular needs. This assessment is considered an important first step for a task force seeking creative approaches to providing more appropriate oral formulations for children.

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Prescribing for children – taste and palatability affect adherence to antibiotics: a review

Abstract: The taste of an antibiotic is often not taken into account by practitioners, although there is signifi cant evidence to show palatability correlates strongly with adherence.

Cited by 127 publications

References 35 publications

Taste acceptance of Captopril and Furosemide Extemporaneous Oral Pediatric Formulations among Hospitalized Children

Taste acceptance of Captopril and Furosemide Extemporaneous Oral Pediatric Formulations among Hospitalized Children

Cephalosporin Antibiotics and Antibiotic Rezistance in Three Decades

A Report from the Pediatric Formulations Task Force: Perspectives on the State of Child-Friendly Oral Dosage Forms

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