Presbyesophagus: Esophageal Motility in Nonagenarians*

Soergel, Konrad H.; Zboralske, F. Frank; Amberg, John R.

doi:10.1172/jci105023

Cited by 181 publications

(55 citation statements)

References 17 publications

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“…The oesophageal motor abnormality associated with aging simulates diffuse oesophageal spasm (Soergel, Zboralske, and Amberg, 1964). Three of our patients were in the seventh decade but had motility disturbances mimicking achalasia, not diffuse spasm.…”

Section: Discussionmentioning

confidence: 67%

Unclassified oesophageal motor disorders simulating achalasia.

Hogan¹,

Caflisch²,

Winship³

1969

Gut

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Section: Discussionmentioning

confidence: 67%

Unclassified oesophageal motor disorders simulating achalasia.

Hogan¹,

Caflisch²,

Winship³

1969

Gut

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“…Estimated that the world population aged over 65 will double over the next 40 years (1,7) . Moreover, it is known that with advancing age there is a decrease in function in several body organs, and among the several changes observed, motility of the gastrointestinal tract is also included (4,9,10,11,17,19) . It has been shown manometric findings similar to those observed in patients with achalasia (decrease in distal esophageal amplitude and complete relaxation of LES) in asymptomatic elderly people with no comorbidity (12,13,17,20) .…”

Section: Discussionmentioning

confidence: 99%

“…A few studies available since the 1960's have been investigating the effect of age on esophageal motility. A study done in nonagenarians (19) demonstrated failure in driving a peristaltic wave and to elicit repetitive simultaneous contractions in the esophagus. However, the subjects had several comorbidities such as diabetes mellitus and neurological diseases, which could influence the results.…”

Section: Discussionmentioning

confidence: 99%

“…Life expectancy has increased significantly over the past 15 years and it is estimated that the world population aged over 65 will double over the next 40 years (1,7) . Moreover, it is known that with advancing age there is a decrease in function in several body organs, and among the several changes observed, motility of the gastrointestinal tract is also included (4,10,11,17,19) . Since the 1960's a few studies have investigated the effect of age on esophageal motility.…”

Section: Introductionmentioning

confidence: 99%

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Achalasia in the elderly patient: a comparative study

Schechter

Lemme

Novais

et al. 2011

Arq. Gastroenterol.

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-Context -Achalasia is a primary esophageal motor disorder secondary to the degeneration of ganglion cells of the inhibitory intramural myenteric plexus. It affects both sexes similarly and has two peaks of incidence, one in the 3rd to 4th decades of life and the other after 60 years of age. The effect of age on esophageal motility of patients with achalasia is not well known. Studies have shown that healthy older people, when compared to the young, have: a) a lower number of ganglion cells in the intramural myenteric plexus; b) a reduced normal relaxation of the lower esophageal sphincter; and c) a reduced esophageal peristalsis. Thus, as both age and achalasia can produce comparable degenerative changes in the intramural myenteric plexus, it is possible that advanced age could be an important factor in enhancing the clinical and manometric abnormalities commonly found in patients with achalasia. Objectives -To compare the clinical, radiological and manometric findings in young as compared to elderly (>60 years old) achalasia patients. Methods -A retrospective study of a group of patients with untreated achalasia separated into young and elderly patients. Demographic, clinical, serology for Chagas' disease, radiological and manometric data were compared between these groups. The level of significance was P<0.05. Results -The study included 105 patients, 52 young (25 M/27 F, mean age 40 years old) and 53 elderly (21 M/32 F, mean age 70 years old). The elderly group had a higher prevalence of Chagas' disease (P = 0.004) and a lower pressure of the lower esophageal sphincter [26.4 mm Hg vs 31.9 mm Hg] P = 0.001, a difference that persisted when analyzed only elderly and young patients with idiopathic achalasia. Younger patients had a higher prevalence of heartburn (P = 0.001) and chest pain (P = 0.012) than the elderly. Conclusion -Elderly patients with achalasia had a lower esophageal sphincter pressure than the young, even when we excluded patients with Chagas' disease but, as a group, they were less symptomatic. HEADINGS -Esophageal achalasia. Aged. Manometry.

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“…Os estudos manométricos e radiológicos realizados na década de 1960 demonstraram que o envelhecimento produzia certos padrões de disfunção esofágica 1,2 . …”

Section: Introductionunclassified

Avaliação da motilidade esofágica em pacientes idosos e comparação com indivíduos não idosos, ambos sintomáticos nas doenças esofágicas

Kunen¹

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Presbyesophagus: Esophageal Motility in Nonagenarians*

Cited by 181 publications

References 17 publications

Unclassified oesophageal motor disorders simulating achalasia.

Unclassified oesophageal motor disorders simulating achalasia.

Achalasia in the elderly patient: a comparative study

Avaliação da motilidade esofágica em pacientes idosos e comparação com indivíduos não idosos, ambos sintomáticos nas doenças esofágicas

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