Presacral Extrarenal Wilms Tumor in a Child

Jia, Hui; Zhang, Ke Ren; Song, Hong; Tian, Bao Ling; Wang, Wei Lin

doi:10.1016/j.urology.2009.01.006

Cited by 14 publications

(5 citation statements)

References 10 publications

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“…Most authors agree that the diagnosis of an ectopic nephroblastoma is always based on the histological examination after surgical removal. 8,12,36 Histologically, nephroblastoma has a classic triphasic pattern composed of epithelial, stromal and blastemal cells, 17,22,37 which are also identified in canine spinal nephroblastoma. 38 However, depending on the degree of differentiation present in the tumour, monophasic or biphasic variants have been described, 17,[39][40][41] making diagnosis more difficult.…”

Section: Discussionmentioning

confidence: 99%

“…Most authors agree that the diagnosis of an ectopic nephroblastoma is always based on the histological examination after surgical removal 8,12,36 . Histologically, nephroblastoma has a classic triphasic pattern composed of epithelial, stromal and blastemal cells, 17,22,37 which are also identified in canine spinal nephroblastoma 38 .…”

Section: Discussionmentioning

confidence: 99%

“…2,3 Intramedullary, multicentric or metastatic locations of spinal nephroblastoma are very rare. [4][5][6] In human medicine, extrarenal nephroblastoma has been described mainly in the retroperitoneum and rarely in the genitourinary tract, inguinal canal, skin and thorax, 7,8 but to the authors' knowledge, these locations have never been identified in animals.…”

Section: Introductionmentioning

confidence: 99%

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Extrarenal nephroblastomas in the inguinal region and paraspinal musculature with vertebral involvement and spinal cord compression in a 12‐year‐old dog

Soler,

Pérez‐Hernández,

Buendía

et al. 2024

Vet Record Case Reports

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A 12‐year‐old, entire, male shar‐pei was presented with a 1‐month history of depression, lumbar pain and progressive hindlimb weakness. In addition, the owners had noticed a mass in the right inguinal region. Computed tomography showed a contrast‐enhanced soft tissue mass located at the right paraspinal musculature, affecting the vertebral body of T13, invading the vertebral canal and compressing the spinal cord. The inguinal mass showed similar imaging characteristics. Due to the uncertain prognosis, euthanasia was recommended, and postmortem examination was requested. Microscopic and immunohistochemical findings were consistent with ectopic nephroblastomas. According to this case report, ectopic nephroblastomas should be considered within the differential diagnosis of masses affecting the paraspinal musculature, as well as the inguinal region, even in senior dogs. To the authors’ knowledge, this is the first report of two ectopic nephroblastomas presented in different locations in a dog.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Extrarenal nephroblastomas in the inguinal region and paraspinal musculature with vertebral involvement and spinal cord compression in a 12‐year‐old dog

Soler,

Pérez‐Hernández,

Buendía

et al. 2024

Vet Record Case Reports

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“…EWT is most often located in the retroperitoneum, followed by the inguinal, scrotum, uterine cavity, lumbosacral subcutaneous, bladder, repeated sigmoid colon, and other locations ( 4 , 5 ). EWT located in the retroperitoneal region commonly manifests as clinical symptoms including abdominal mass, pain, and compression of adjacent organs ( 6 ). While a preoperative CT scan can aid in the detection of retroperitoneal tumors, accurately diagnosing EWT using this imaging method is challenging due to the absence of distinctive CT signs.…”

Section: Discussionmentioning

confidence: 99%

Case report: The CT features of pediatric retroperitoneal extrarenal Wilms tumor: a report of two cases and literature review

Li,

Wang,

Chen

et al. 2023

Front. Pediatr.

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Retroperitoneal extrarenal Wilms tumor is a rare condition in children that can be easily misdiagnosed as other retroperitoneal malignancies unrelated to the renal origin. Computerized tomography scan plays a crucial role in diagnosing and distinguishing retroperitoneal malignancies. In this report, we present two cases of retroperitoneal extrarenal Wilms tumor in children who were admitted due to abdominal mass. Laboratory examination did not reveal any significant abnormality. However, a computerized tomography scan revealed a solid or cystic-solid mass in the retroperitoneum accompanied by a bone spur extending from the anterior edge of the vertebral body to the back of the mass, while the origin of the tumor remained unclear. By analyzing these two cases and reviewing previous studies on retroperitoneal extrarenal Wilms tumor in children, we summarized the clinical and imaging characteristics of this rare condition. We also found that the presence of a spinal deformity adjacent to the mass might indicate the possibility of a retroperitoneal extrarenal Wilms tumor.

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“…63,64 It has been reported in a variety of locations including the retroperitoneum, inguinal and paratesticular region, female genital tract, bladder, thorax, and lambosacral region. [65][66][67][68] First, a primary tumor in the kidney should be excluded.…”

Section: Extrarenal Wilms Tumor (Erwt)mentioning

confidence: 99%

Wilms Tumor

Al-Hussain¹,

Ali

Akhtar³

2014

Advances in Anatomic Pathology

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Wilms tumor (WT) is the most common neoplasm of the kidney in children. It is an embryologic tumor that histologically mimics renal embryogenesis and is composed of a variable mixture of stromal, blastemal, and epithelial elements. Nephrogenic rests, generally considered to be precursor lesions of the WT, are foci of the embryonic metanephric tissue that persist after the completion of renal embryogenesis. These are classified as perilobar and intralobar based on their location and maybe present as single or multiple foci. Intralobar and perilobar rests and the tumors arising from these rests differ morphologically and are characterized by 2 different sets of genetic abnormalities involving 2 adjacent foci, WT1 and WT2, on the short arm of chromosome 11. WTs arising in the intralobar rests tend to be stromal predominant and have a mutation or deletion of WT1. Germline mutation in WT1 may be associated with syndromic conditions such as WAGR and Denys-Drash syndromes. Perilobar rests and their corresponding tumors usually have loss of imprinting/loss of heterozygosity involving WT2, which contains several parentally imprinted genes. Loss of function of these genes, if present constitutionally, may be associated with Beckwith-Wiedemann syndrome or may result in isolated hypertrophy. Abnormalities in several other genes may also be seen in WT. These include WTX, (on chromosome X), CTNNB1 (chromosome 3), and TP53 (chromosome 17) among others. WT with loss of heterozygosity at 1p and 16q may have poor prognosis, requiring aggressive therapy. Treatment modalities for WT have evolved over many decades, primarily through the efforts of Dr J Bruce Beckwith at National WT study. This work is now being carried out by Children Oncology Group in North America and International Society of Pediatric Oncology in Europe. Although their therapeutic approaches are somewhat different, both have reported excellent results with equally high cure rates.

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Presacral Extrarenal Wilms Tumor in a Child

Cited by 14 publications

References 10 publications

Extrarenal nephroblastomas in the inguinal region and paraspinal musculature with vertebral involvement and spinal cord compression in a 12‐year‐old dog

Extrarenal nephroblastomas in the inguinal region and paraspinal musculature with vertebral involvement and spinal cord compression in a 12‐year‐old dog

Case report: The CT features of pediatric retroperitoneal extrarenal Wilms tumor: a report of two cases and literature review

Wilms Tumor

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