Prerigor injection using glycolytic inhibitors in low-quality beef muscles1

Jerez, Nancy; Calkins, Chris R.; Velazco, Jesus

doi:10.2527/2003.814997x

Cited by 18 publications

(6 citation statements)

References 26 publications

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“…The extreme effects of slaughter on the body (i.e., accelerated anaerobic metabolism, decrease in muscle pH, loss of blood and oxygen supply to the muscle, and loss of homeostasis) were assumed to be somewhat similar to exhaustive anaerobic exercise, but neither CIT nor ACE administration affected postmortem muscle pH conditions in our study. Injection of CIT directly into prerigor beef inhibited postmortem glycolysis and improved tenderness (Jerez et al, 2003). However, injecting CIT into prerigor porcine muscle elevated pH, but neither CIT nor ACE administration had an effect on glycolytic metabolites (Stephens et al, 2006).…”

Section: Postmortem Glycolysis and Early Postmortem Phmentioning

confidence: 99%

Effects of oral administration of sodium citrate or acetate to pigs on blood parameters, postmortem glycolysis, muscle pH decline, and quality attributes of pork1,2

Stephens

Dikeman

Unruh

et al. 2008

Journal of Animal Science

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The objective of this study was to determine the effects of oral administration of sodium citrate (CIT) or acetate (ACE) to pigs on blood parameters, postmortem glycolysis, pH decline, and quality attributes of pork. Previous studies have shown that CIT has the potential to inhibit phosphofructokinase (PFK), a key enzyme in postmortem muscle glycolysis. In Exp. 1, CIT, ACE, or water was orally administered (0.75 g/ kg of BW) to 24 pigs. After a 30-min rest, pigs were exercised, and blood samples were taken at 45 and 75 min after oral treatment. Citrate and ACE tended (P = 0.08) to increase blood pH and increased (P = 0.02) bicarbonate levels immediately after exercise. After a 30-min rest, blood pH of pigs administered ACE tended (P = 0.09) to remain higher, whereas blood pH of CITtreated pigs was similar to that of control pigs. Bicarbonate levels in ACE-and CIT-treated pigs were still

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Section: Postmortem Glycolysis and Early Postmortem Phmentioning

confidence: 99%

Effects of oral administration of sodium citrate or acetate to pigs on blood parameters, postmortem glycolysis, muscle pH decline, and quality attributes of pork1,2

Stephens

Dikeman

Unruh

et al. 2008

Journal of Animal Science

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“…It may be related to the potential of SC used as a glycolytic inhibitor for pre-rigor of beef and also be related to the alkalinity of SC itself. [26] The results also shown that a* values of all treatments significantly decreased with storage time. It may be attributed to the oxidation of myoglobin and formation of metmyoglobin.…”

Section: Itemsmentioning

confidence: 71%

Quality of vacuum packaged beef as affected by aqueous ozone and sodium citrate treatment

Zhang

Wang

Song

et al. 2020

International Journal of Food Properties

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This study was targeted to investigate the effect of the combination of aqueous ozone (AO) and sodium citrate (SC) pretreatment on quality of vacuum packaged beef stored at chilling temperature. The steers were randomly divided into five treatment groups, containing the group C (steers without any treatment), DW (steers pretreated with distilled water), AO, SC and AO+SC. During processing, the parameters included total Viable Count (TVC), total Volatile Basic Nitrogen (TVB-N), pH, meat color, metmyoglobin (Met-Mb), thiobarbituric acid reactive substances (TBArs), Warner-Bratzler shear force (WBSF), and purge loss were measured and compared. Firstly, the TVC in beef steaks of group AO+SC was significantly lower than group AO and SC during the whole storage (P < .05). In addition, the TVB-N values in AO+ SC group were significantly decreased than AO group at the end of storage time. Furthermore, compared with the group only treated by AO, the group AO+SC displayed higher L* (lightness) value, lower a* (redness) value and lower Met-Mb. The values of WBSF and purge loss of group AO+SC was lower than group AO, as well as TBArs. The treatment methods and storage time had significant interactive effects on TVC, TVB-N, pH, L*, Met-Mb, and TBArs (P < .05). The combination treatment of AO and SC showed better effect on inhibiting the microbial growth and decreased the deteriorated effect of AO on beef quality including TBArs, WBSF, and purge loss.

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“…Most tumor cells have a lower pH value than normal cells. Treatment of prerigor muscle with sodium citrate or sodium fluoride maintained the pH of the muscle at 6.18 and 5.93, respectively (113). Lactic acid formation was prevented, and glycogen breakdown was delayed or inhibited.…”

Section: Therapeutic Strategies For Hypoxia-induced Angiogenic Diseasesmentioning

confidence: 98%

Hypoxia Inducible Factor Pathways as Targets for Functional Foods

Losso

Bawadi

2005

J. Agric. Food Chem.

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The etiology of most chronic angiogenic diseases such as rheumatoid arthritis, atherosclerosis, diabetes complications, and cancer includes the presence of pockets of hypoxic cells growing behind aerobic cells and away from blood vessels. Hypoxic cells are the result of uncontrolled growth and insufficient vascularization and have undergone a shift from aerobic to anaerobic metabolism. Cells respond to hypoxia by stimulating the expression of hypoxia inducible factor (HIF), which is critical for survival under hypoxic conditions and in embryogenesis. HIF is a heterodimer consisting of the O2-regulated subunit, HIF-1alpha, and the constitutively expressed aryl hydrocarbon receptor nuclear translocator, HIF-1beta. Under hypoxic conditions, HIF-1alpha is stable, accumulates, and migrates to the nucleus where it binds to HIF-1beta to form the complex (HIF-1alpha + HIF-1beta). Transcription is initiated by the binding of the complex (HIF-1alpha + HIF-1beta) to hypoxia responsive elements (HREs). The complex [(HIF-1alpha + HIF-1beta) + HREs] stimulates the expression of genes involved in angiogenesis, anaerobic metabolism, vascular permeability, and inflammation. Experimental and clinical evidence show that these hypoxic cells are the most aggressive and difficult angiogenic disease cells to treat and are a major reason for antiangiogenic and conventional treatment failure. Hypoxia occurs in early stages of disease development (before metastasis), activates angiogenesis, and stimulates vascular remodeling. HIF-1alpha has also been identified under aerobic conditions in certain types of cancer. This review summarizes the role of hypoxia in some chronic degenerative angiogenic diseases and discusses potential functional foods to target the HIF-1alpha pathways under hypoxic and normoxic conditions. It is reported that dietary quinones, semiquinones, phenolics, vitamins, amino acids, isoprenoids, and vasoactive compounds can down-regulate the HIF-1 pathways and therefore the expression of several proangiogenic factors. Considering the lack of efficiency or the side effects of synthetic antiangiogenic drugs at clinical trials, down-regulation of hypoxia-induced angiogenesis by use of naturally occurring functional foods may provide an effective means of prevention.

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Prerigor injection using glycolytic inhibitors in low-quality beef muscles1

Cited by 18 publications

References 26 publications

Effects of oral administration of sodium citrate or acetate to pigs on blood parameters, postmortem glycolysis, muscle pH decline, and quality attributes of pork1,2

Effects of oral administration of sodium citrate or acetate to pigs on blood parameters, postmortem glycolysis, muscle pH decline, and quality attributes of pork1,2

Quality of vacuum packaged beef as affected by aqueous ozone and sodium citrate treatment

Hypoxia Inducible Factor Pathways as Targets for Functional Foods

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