Preradiotherapy Hemoglobin Level but not Microvessel Density Predicts Locoregional Control and Survival in Laryngeal Cancer Treated with Primary Radical Radiotherapy

Haugen, Hedda; Magnusson, Bengt; Svensson, Marie; Mercke, Claes

doi:10.1158/1078-0432.ccr-04-0871

Cited by 10 publications

(3 citation statements)

References 31 publications

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“…Although there are substantial data implying that poorly vascularized tumors are resistant to chemotherapy and/or radiotherapy, no definitive conclusion has been drawn at present on the clinical usefulness of MVD as a marker for prognosis. There are some studies that did not show a relationship between MVD and survival (18,19) and a reverse relationship between MVD and survival has been reported by some groups (20,21).…”

Section: Discussionmentioning

confidence: 94%

Computer-Assisted Analysis of Biopsy Specimen Microvessels Predicts the Outcome of Esophageal Cancers Treated with Chemoradiotherapy

Zhang

Hironaka²,

Ohtsu³

et al. 2006

Clinical Cancer Research

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Purpose: A computer-assisted microvessel analysis system was developed to evaluate correlations between the architecture of biopsy specimen microvessels and the outcome for patients with esophageal cancer treated with chemoradiotherapy. Experimental Design: Biopsy specimens from 51 patients with esophageal cancer (T 2-3 , any N, M 0 ) treated with chemoradiotherapy were immunostained with an anti-CD31 antibody and quantified using computerized image analysis.We evaluated the association of several microvessel factors with overall survival, including the ratio of total microvessel perimeter to total tumor area (TP/TA), the tumor hypoxic ratio, and the ratio of total microvessel number to total tumor area (TN/ TA). Results from traditional manual microvessel density (MVD) hotspot count and computerized hotspot count were compared and the relation between hotspot MVD count and survival rate was evaluated. Results: The median follow-up time was 32 months. Both univariate and multivariate analyses revealed that computer-counted hotspot MVD andTN/TA andTP/TA ratios correlated significantly with the outcome of chemoradiotherapy. Kaplan-Meier survival curves showed that patients with high computer-counted hotspot MVDs and highTN/TA andTP/TA ratios had better overall survival rate than patients with low MVDs or ratios (P = 0.025, 0.008, and 0.031, respectively). Combining computer-counted MVD orTN/TA ratio withTP/TA ratio proved more predictive than any single factor.Two researcher-counted hotspot MVDs had no significant relation with outcome. Conclusion: Computer-assisted tumor microvessel analysis is a powerful tool in predicting the outcome for patients with esophageal cancer treated with chemoradiotherapy because intraobserver and interobserver variability is minimized.

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Section: Discussionmentioning

confidence: 94%

Computer-Assisted Analysis of Biopsy Specimen Microvessels Predicts the Outcome of Esophageal Cancers Treated with Chemoradiotherapy

Zhang

Hironaka²,

Ohtsu³

et al. 2006

Clinical Cancer Research

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“…Anemia is an independent risk factor for survival in most cancers, especially in the context of curative radiotherapy (e.g., [42,61,69,71,77,105,132,137,145,[153][154][155][156][157]). Animal study data consistently show that correcting anemia with an ESA improves the response to radiotherapy or chemotherapy [102,145,156].…”

Section: Correction Of Anemia: From Animal Studiesmentioning

confidence: 99%

Erythropoiesestimulierende Substanzen: günstiges Sicherheitsprofil bei indikationskonformer Anwendung

Nowrousian¹,

Dunst

Vaupel

2008

Strahlenther Onkol

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When used as indicated, ESAs are valuable and safe drugs for the treatment of anemia and do not negatively affect patient survival. In particular, the data situation confirms the importance and correctness of the EORTC guidelines 2006 and their recently updated version. It is therefore recommended that these guidelines continue to be strictly followed in the treatment of chemotherapy-induced anemia.

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“…As the gold standard for evaluating tumor angiogenesis, MVD has been demonstrated to correlate with the subtypes of malignant tumors. In addition, the prognostic relevance of angiogenesis assessed by MVD has been reported in various tumor types, such as breast, liver, laryngeal, and nasopharyngeal cancers (7–9). Ki-67, one of the biological markers used to evaluate proliferation, is well characterized at the molecular level and is extensively used in tumor diagnosis, tumor grading, evaluation of tumor aggressiveness (10), treatment response, tumor recurrence, and survival rate in multiple cancers (11–14).…”

Section: Introductionmentioning

confidence: 99%

Dynamic contrast-enhanced MRI perfusion parameters are imaging biomarkers for angiogenesis in lung cancer

Zhang

Liang

et al. 2022

Acta Radiol

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Background Quantitative parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) may have the potential to reflect angiogenesis and proliferation of pulmonary neoplasms. Purpose To verify whether DCE-MRI can identify pulmonary neoplasm property and evaluate the correlation of DCE-MRI perfusion parameters with microvessel density (MVD) and Ki-67 in lung cancer. Material and Methods This study enrolled 65 patients with one pulmonary neoplasm who underwent computed tomography-guided percutaneous lung biopsy with pathological diagnosis (43 malignant, 22 benign; mean age = 59.71 ± 11.72 years). All patients did DCE-MRI before biopsy. Quantitative MRI parameters including endothelial transfer constant (Ktrans), flux rate constant (Kep), and fractional extravascular extracellular space (EES) volume (Ve) were calculated by extended Tofts linear model. MVD was evaluated by CD34-expressing tumor vessels. Proliferation was assessed by Ki-67 staining. The correlations of parameters with MVD and Ki-67 expression were analyzed. Results Ktrans and Kep values were significantly increased in malignant lesions compared to benign lesions ( P = 0.001 and 0.022, respectively), whereas no statistical difference in Ve was found. The CD34 expression was positively correlated to Ktrans ( r = 0.608; P = 0.004) and Kep ( r = 0.556; P = 0.001). Subsequent subtype analyses also showed positive correlations of Ktrans and Kep with MVD in adenocarcinoma group ( r = 0.550 and 0.563; P = 0.012 and 0.015, respectively). No significant correlation was found between these parameters and Ki-67. Conclusion Ktrans and Kep may distinguish benign and malignant pulmonary neoplasm. Ktrans and Kep, with their positive correlation to MVD, can be used as non-invasive parameters reflecting lung cancer angiogenesis.

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Preradiotherapy Hemoglobin Level but not Microvessel Density Predicts Locoregional Control and Survival in Laryngeal Cancer Treated with Primary Radical Radiotherapy

Cited by 10 publications

References 31 publications

Computer-Assisted Analysis of Biopsy Specimen Microvessels Predicts the Outcome of Esophageal Cancers Treated with Chemoradiotherapy

Computer-Assisted Analysis of Biopsy Specimen Microvessels Predicts the Outcome of Esophageal Cancers Treated with Chemoradiotherapy

Erythropoiesestimulierende Substanzen: günstiges Sicherheitsprofil bei indikationskonformer Anwendung

Dynamic contrast-enhanced MRI perfusion parameters are imaging biomarkers for angiogenesis in lung cancer

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