Prepulse inhibition of auditory change-related cortical responses

Inui, Koji; Tsuruhara, Aki; Kodaira, Minori; Motomura, Eishi; Tanii, Hisashi; Nishihara, Makoto; Keceli, Sumru; Kakigi, Ryusuke

doi:10.1186/1471-2202-13-135

Cited by 35 publications

(67 citation statements)

References 42 publications

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“…From the event-related potentials, we analyzed the N1 component to Pulse-only and to Pulse. The PPI of cortical evoked potentials was investigated for the N1 response amplitude [4] as the P1 and N2 responses to the Pulse were very weak. N1 was defined as the first negative deflection within a time window of 0 ms-70 ms after the tone onset (Pulseonly or Pulse).…”

Section: Data Collection and Analysismentioning

confidence: 99%

“…During this process, the sensory information is forward-masked so that an individual can focus on the most salient aspects of the sensory environment [2,3]. Most studies on PPI have focused on such physiological measures as the eye-blink reflex in humans and wholebody flinching in rodents, while only a few studies [4,5] have shed light on the PPI of auditory cortical processing. PPI has also been used to investigate the biology of some neuropsychiatric disorders [2,3,6,7].…”

Section: Introductionmentioning

confidence: 99%

“…Studies on humans using electroencephalography (EEG) suggest that several components of the auditory evoked potentials (P50, N1, P2, and P3) exhibit PPI [8]. The amplitude of the N1 response to the Pulse-only stimulus is correlated positively with both the N1 amplitude of the prepulse-evoked response and with the degree of PPI [4]. Also alpha-, theta-, and gamma-band oscillatory activity exhibits PPI in humans [5].…”

Section: Introductionmentioning

confidence: 99%

“…Due to the suggested clinical relevance of the PPI in neuropsychiatric disorders [2,3,6,7], there is a need to further investigate the neuronal mechanisms underlying the PPI of cortical responses. The startle reflex of the PPI has been extensively studied in rat models and, more recently, the neuronal mechanisms of PPI have been investigated in humans using magnetoencephalography (MEG) and EEG [4,5,8,9]. Non-human primate models have been successfully used to study human brain functions and to model brain disorders [10,11].…”

Section: Introductionmentioning

confidence: 99%

“…We hypothesized that the cortical responses to a strong auditory stimulus in the STGcb are suppressed by a preceding weaker auditory stimulus in a manner similar to the PPI of the startle reflex. We also hypothesized that the presence of a conspecific, which draws attention away from the auditory stimulation, suppresses auditory processing in the STGcb but does not affect the PPI of cortical responses, as PPI is considered to be a pre-attentive process [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

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Prepulse Inhibition of Auditory Cortical Responses in the Caudolateral Superior Temporal Gyrus in Macaca mulatta

et al. 2017

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Prepulse inhibition (PPI) refers to a decreased response to a startling stimulus when another weaker stimulus precedes it. Most PPI studies have focused on the physiological startle reflex and fewer have reported the PPI of cortical responses. We recorded local field potentials (LFPs) in four monkeys and investigated whether the PPI of auditory cortical responses (alpha, beta, and gamma oscillations and evoked potentials) can be demonstrated in the caudolateral belt of the superior temporal gyrus (STGcb). We also investigated whether the presence of a conspecific, which draws attention away from the auditory stimuli, affects the PPI of auditory cortical responses. The PPI paradigm consisted of Pulse-only and Prepulse ? Pulse trials that were presented randomly while the monkey was alone (ALONE) and while another monkey was present in the same room (ACCOMP). The LFPs to the Pulse were significantly suppressed by the Prepulse thus, demonstrating PPI of cortical responses in the STGcb. The PPI-related inhibition of the N1 amplitude of the evoked responses and cortical oscillations to the Pulse were not affected by the presence of a conspecific. In contrast, gamma oscillations and the amplitude of the N1 response to Pulse-only were suppressed in the ACCOMP condition compared to the ALONE condition. These findings demonstrate PPI in the monkey STGcb and suggest that the PPI of auditory cortical responses in the monkey STGcb is a pre-attentive inhibitory process that is independent of attentional modulation.

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Section: Data Collection and Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prepulse Inhibition of Auditory Cortical Responses in the Caudolateral Superior Temporal Gyrus in Macaca mulatta

et al. 2017

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Auditory change‐related cortical response is associated with hypervigilance to pain in healthy volunteers

Otsuru

Ogawa

Yokota

et al. 2021

European Journal of Pain

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Background: Patients with chronic pain exhibit hypervigilance (heightened responsiveness to stimuli) to innocuous auditory stimuli as well as noxious stimuli."Generalized hypervigilance" suggests that individuals who show heightened responsiveness to one sensory system also show hypervigilance to other modalities. However, research exploring the existence of generalized hypervigilance in healthy subjects is limited.Methods: We investigated whether hypervigilance to pain is associated with auditory stimuli in healthy subjects using the pain vigilance and awareness questionnaire (PVAQ) and auditory change-related cortical responses (ACRs). ACRs are thought to reflect a change detection system, based on preceding sensory memory. We recorded ACRs under conditions that varied in terms of the accumulation of sensory memory as follows: short-ACR, with short preceding continuous stimuli and long-ACR, with long preceding continuous stimuli. In addition, the attention to pain (PVAQ-AP) and attention to changes in pain (PVAQ-ACP) subscales were evaluated.Results: Amplitudes of long-ACR showed significant positive correlations with PVAQ-ACP, whereas those of short-ACR did not show any significant correlations. Conclusions: Generalized hypervigilance may be observed even in healthy subjects. ACR may be a useful index to evaluate the hypervigilance state in the human brain.

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Assessment of haptic memory using somatosensory change‐related cortical responses

Sugiyama

Kinukawa

Takeuchi

et al. 2020

Human Brain Mapping

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Haptic memory briefly retains somatosensory information for later use; however, how and which cortical areas are affected by haptic memory remain unclear. We used change‐related cortical responses to investigate the relationship between the somatosensory cortex and haptic memory objectively. Electrical pulses, at 50 Hz with a duration of 500 ms, were randomly applied to the second, third, and fourth fingers of the right and left hands at an even probability every 800 ms. Each stimulus was labeled as D (preceded by a different side) or S (preceded by the same side). The D stimuli were further classified into 1D, 2D, and 3D, according to the number of different preceding stimuli. The S stimuli were similarly divided into 1S and 2S. The somatosensory‐evoked magnetic fields obtained were divided into four components via a dipole analysis, and each component's amplitudes were measured using the source strength waveform. The results showed that the preceding event did not affect the amplitude of the earliest 20–30 ms response in the primary somatosensory cortex. However, in the subsequent three components, the cortical activity amplitude was largest in 3D, followed by 2D, 1D, and S. These results indicate that such modulatory effects occurred somewhere in the somatosensory processing pathway higher than Brodmann's area 3b. To the best of our knowledge, this is the first study to demonstrate the existence of haptic memory for somatosensory laterality and its impact on the somatosensory cortex using change‐related cortical responses without contamination from peripheral effects.

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Prepulse inhibition of auditory change-related cortical responses

Cited by 35 publications

References 42 publications

Prepulse Inhibition of Auditory Cortical Responses in the Caudolateral Superior Temporal Gyrus in Macaca mulatta

Prepulse Inhibition of Auditory Cortical Responses in the Caudolateral Superior Temporal Gyrus in Macaca mulatta

Auditory change‐related cortical response is associated with hypervigilance to pain in healthy volunteers

Assessment of haptic memory using somatosensory change‐related cortical responses

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