Prepubertal gynecomastia at the debut of hereditary tumors predisposition syndrome (clinical case reports)
M. A. Kareva,
L. S. Sozaeva,
I. S. Chugunov
et al.
Abstract:Peutz-Jeghers Syndrome (Peutz-Jeghers Syndrome, PJS) refers to syndromes of hereditary tumor predisposition and is caused by pathological variants of the STK11 gene, leading to a defect in the synthesis of serine/threonine kinase 11 protein, which acts as a tumor suppressor.Clinical symptoms of the syndrome are combination of hamartomatous polyposis of the gastrointestinal tract and specific skin-mucosal hyperpigmentation. Also, this disease is characterized by a high risk of developing gastrointestinal and ex… Show more
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