Prepubertal exposure to arsenic alters male reproductive parameters in pubertal and adult rats

Santos, Felipe Couto; Souza, Ana Cláudia Ferreira; Bastos, Daniel Silva Sena; Ervilha, Luiz Otávio Guimarães; Dias, Fernanda Carolina Ribeiro; Araújo, Larissa de; Guimarães, Simone Eliza Facioni; Oliveira, Leandro Licursi de; Machado‐Neves, Mariana

doi:10.1016/j.taap.2020.115304

Cited by 20 publications

(18 citation statements)

References 53 publications

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“…In vitro cell cultures of rodent testes and epididymis treated with sodium arsenite at concentrations of 1, 10, 50, and 100 µM for 2 and 24 h increased ROS, TBARS, and sperm DNA damage, decreased catalase, peroxidase, and superoxide dismutase, and decreased serum testosterone [157]. Sodium arsenite at a dose of 10 mg/L through drinking water was shown to induce overexpression of SOD1, CAT, GSTK1, and MT1 in the testes and epididymis of rats [148].…”

Section: Arsenic-induced Oxidative Stressmentioning

confidence: 91%

Contemporary Comprehensive Review on Arsenic-Induced Male Reproductive Toxicity and Mechanisms of Phytonutrient Intervention

Rachamalla

Chinthada

Kushwaha

et al. 2022

Toxics

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Arsenic (As) is a poisonous metalloid that is toxic to both humans and animals. Drinking water contamination has been linked to the development of cancer (skin, lung, urinary bladder, and liver), as well as other disorders such as diabetes and cardiovascular, gastrointestinal, neurological, and developmental damage. According to epidemiological studies, As contributes to male infertility, sexual dysfunction, poor sperm quality, and developmental consequences such as low birth weight, spontaneous abortion, and small for gestational age (SGA). Arsenic exposure negatively affected male reproductive systems by lowering testicular and accessory organ weights, and sperm counts, increasing sperm abnormalities and causing apoptotic cell death in Leydig and Sertoli cells, which resulted in decreased testosterone synthesis. Furthermore, during male reproductive toxicity, several molecular signalling pathways, such as apoptosis, inflammation, and autophagy are involved. Phytonutrient intervention in arsenic-induced male reproductive toxicity in various species has received a lot of attention over the years. The current review provides an in-depth summary of the available literature on arsenic-induced male toxicity, as well as therapeutic approaches and future directions.

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Section: Arsenic-induced Oxidative Stressmentioning

confidence: 91%

Contemporary Comprehensive Review on Arsenic-Induced Male Reproductive Toxicity and Mechanisms of Phytonutrient Intervention

Rachamalla

Chinthada

Kushwaha

et al. 2022

Toxics

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“…94 Another study on arsenic exposed epididymis of post-natal rats (52 days age) has reported a significant up-regulation of SOD1, CAT and GSTK1 genes in response to combat with the arsenic-induced oxidative stress. 87 Increase of MDA level and decrease of enzymatic CAT activity have also been observed also suggesting altered redox state. 87 Recently Souza ACF 93 has reported that arsenic exposure on post-natal rats of 14 and 28 days caused increased activity of CAT to neutralize arsenic induced reactive species but exhaustion occurred finally reducing the activity below normal level.…”

Section: Redox Balancementioning

confidence: 94%

“…87 Increase of MDA level and decrease of enzymatic CAT activity have also been observed also suggesting altered redox state. 87 Recently Souza ACF 93 has reported that arsenic exposure on post-natal rats of 14 and 28 days caused increased activity of CAT to neutralize arsenic induced reactive species but exhaustion occurred finally reducing the activity below normal level. Souza ACF 93 has also stated that arsenic induced reduction of epididymal GST activity in post-natal rats of 28 days validating the malfunction of antioxidant enzyme that act against arsenic mediated oxidative stress.…”

Section: Redox Balancementioning

confidence: 94%

“…84 A recent study on arsenic exposed epididymis of pre-pubertal rats (52 and 82 days age) reported cribiform appearance in the epithelium, lack of spermatozoa in the lumen, presence of vacuoles and cell debris indicating disruption of luminal microenvironment leading to impairment of spermatozoal maturation. 87…”

Section: Effects Of Arsenic Toxicity Structural Amendmentsmentioning

confidence: 99%

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Molecular perspective concerning fluoride and arsenic mediated disorders on epididymal maturation of spermatozoa: A concise review

2021

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Epididymis is a complex tubular structure of male reproductive system where spermatozoa undergo maturation and gain the fertilizing ability. Epididymal pseudostratified columnar epithelium with different cell types play imperative role by their secretory properties and enrich the luminal microenvironment necessary for achieving spermatozoal motility. During epididymal transit several secretory proteins like P26h, SPAG11, HSPD1 and many others are deposited on spermatozoal surface. At the same time spermatozoal proteins are also modified in this intraluminal milieu, which include cyritestin, fertilin, CE9 and others. Natural and anthropogenic activities disclose various environmental pollutants which affect different physiological systems of animals and human being. Likewise, reproductive system is also being affected. Fluoride causes structural alterations of caput and cauda segments of epididymis. Redox homeostasis and functional integrity are also altered due to diminished activities of SOD1, GR, Crisp2, Lrp2 and other important proteins. On the contrary arsenic affects mostly on cauda segment. Redox imbalance and functional amendment in epididymis have been observed with arsenic revelation as evidenced by altered genomic appearance of SOD, GST, catalase, Ddx3Y, VEGF and VEGFR2. This review is dealt with structure-function interplay in normal epididymal spermatozoal maturation along with subsequent complications developed under fluoride and arsenic toxicities.

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“…However, Blackburn et al (2011) developed GSTK1-deficient mice without overt oxidative stress in the kidneys or liver and without NADPH quinone oxidoreductase 1 expression elevation. Additionally, male rats with reproductive disorders caused by prenatal arsenic exposure have shown changes in GSTK1 expression (Couto-Santos et al, 2020;Souza et al, 2021). GSTK1 is upregulated in the spermatozoa of highly fertile boars .…”

mentioning

confidence: 99%

Glutathione S‐transferase kappa 1 is positively related with sperm quality of porcine sperm

Zeng

Huang

et al. 2021

Molecular Reproduction Devel

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The glutathione S-transferase (GST) superfamily members play an important role in the male reproductive tract and sperm physiology. However, the expression profiles of some members of this protein family and their effect on sperm quality remain unclear. In this study, we found that GST kappa 1 (GSTK1) encoded protein is abundant in the testes and capacitated sperm acrosome. Western blot analysis revealed that the decreased abundance of GSTK1 was observed in low motile spermatozoa; moreover, GSTK1 expression decreased in sperm stored at 17°C under a long preservation time. In vitro analyses revealed that GSTK1 had no significant effect on sperm motility, capacitation, or acrosome reaction. Notably, after capacitated sperm were incubated with 4 and 8 μg/ml anti-GSTK1 antibodies, the fertilization rate significantly decreased in vitro fertilization assay. The current study demonstrates that GSTK1 is correlated with sperm quality and is a promising marker for the assessment of sperm quality and provides a basis for understanding the potential molecular mechanism for targeting pathogenic factors in male infertility.

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Prepubertal exposure to arsenic alters male reproductive parameters in pubertal and adult rats

Cited by 20 publications

References 53 publications

Contemporary Comprehensive Review on Arsenic-Induced Male Reproductive Toxicity and Mechanisms of Phytonutrient Intervention

Contemporary Comprehensive Review on Arsenic-Induced Male Reproductive Toxicity and Mechanisms of Phytonutrient Intervention

Molecular perspective concerning fluoride and arsenic mediated disorders on epididymal maturation of spermatozoa: A concise review

Glutathione S‐transferase kappa 1 is positively related with sperm quality of porcine sperm

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