Preprocedural serum levels of acute-phase reactants and prognosis after percutaneous coronary intervention

Rahel, Braim M.; Visseren, Frank L.J.; Suttorp, Maarten-Jan; Plokker, Thijs H. W. M.; Kelder, Johannes C.; Jongh, B. M. De; Bouter, K.P.; Diepersloot, R.J.A.

doi:10.1016/s0008-6363(03)00355-9

Cited by 67 publications

(39 citation statements)

References 28 publications

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“…During the past decade, CRP has emerged as a significant predictor of cardiovascular events in both healthy subjects and patients with coronary artery disease, with consistent clinical evidence. [6][7][8][9][10] Furthermore, the CRP level has been shown to be an independent predictor of future cardiovascular events, adding prognostic information to the Framingham Risk Score, to lipid screening, and to the metabolic syndrome. 19 Thus, in the area of primary prevention, the usefulness of the criterion encompassing the CRP modified ischemic heart disease risk score for global risk prediction is being increasingly recognized.…”

Section: Discussionmentioning

confidence: 99%

“…5 Numerous studies have incontrovertibly demonstrated the strong predictive value of high-sensitivity CRP (hsCRP) for adverse cardiac events in patients undergoing percutaneous coronary intervention (PCI) and with myocardial infarction (MI). [6][7][8][9][10] As a result, CRP is rapidly evolving into a stronger risk predictor than other novel risk factors in the setting of coronary ischemia and unstable angina. However, its predictive role and clinical application in patients undergoing coronary artery bypass graft surgery (CABG) remains controversial.…”

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confidence: 99%

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Predictive Value of C-Reactive Protein for Major Postoperative Complications Following Off-Pump Coronary Artery Bypass Surgery Prospective and Observational Trial

Kim

Shim

Hong

et al. 2009

Circ J

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Background: To prospectively investigate the predictive value of the preoperative C-reactive protein (CRP) concentration for major postoperative complications following off-pump coronary artery bypass (OPCAB) surgery. Methods and Results: From January 2007 to December 2007, 185 consecutive patients scheduled for elective OPCAB surgery were allocated to a low-CRP group (n=137, CRP <0.3 mg/dl) and a high-CRP group (n=48, CRP ≥0.3 mg/dl). The incidence of major postoperative complications, defined as postoperative myocardial infarction, and 5 major morbidity endpoints including permanent stroke, renal dysfunction, any cardiac surgery reoperation, ventilation for more than 48 h, and deep sternal wound infection were assessed and compared. Multivariate logistic regression was used to determine the predictors of major postoperative complications. Patients in the high-CRP group had a significantly higher overall incidence of major postoperative complications, particularly renal dysfunction. In the multivariate logistic regression model, adjusting all the significant univariate predictors, baseline CRP >0.3 mg/dl and preoperative chronic renal failure (CRF) remained as significant independent predictors of major postoperative complications. Conclusions: Elevated preoperative CRP level and/or preoperative CRF indicate increased risk of developing major postoperative complications, particularly acute postoperative renal dysfunction in patients undergoing OPCAB surgery. (Circ J 2009; 73: 872 -877)

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Predictive Value of C-Reactive Protein for Major Postoperative Complications Following Off-Pump Coronary Artery Bypass Surgery Prospective and Observational Trial

Kim

Shim

Hong

et al. 2009

Circ J

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“…On the other hand, clinical reports indicated a tendency to restenosis after percutaneous coronary intervention in patients with high expression of inflammatory factors (29). Furthermore, molecular biology studies have indicated that the mRNA expression levels of proinflammatory cytokines and chemokines such as IFN-␥, IL-1␤, IL-6, TNF-␣, MCP-1, and RANTES (regulated upon activation, normal T cell expressed and presumably secreted) were markedly elevated in cuff-injured arteries compared with control intact arteries (1,8).…”

Section: S6kmentioning

confidence: 99%

PTEN reduces cuff-induced neointima formation and proinflammatory cytokines

Koide

Okazaki²,

Tamura³

et al. 2007

American Journal of Physiology-Heart and Circulatory Physiology

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reduces cuff-induced neointima formation and proinflammatory cytokines. Am J Physiol Heart Circ Physiol 292: H2824 -H2831, 2007. First published February 2, 2007; doi:10.1152/ajpheart.01221.2006.-An inflammatory response followed by vascular injury plays an important role in neointima formation and development of atherosclerotic lesions, which are in part mediated by proinflammatory cytokines. Using a cuff injury model, we examined the effects of adenovirusmediated overexpression of phosphatase and tensin homology deleted on chromosome 10 (PTEN) on neointima formation and the proinflammatory response. A cuff was placed around the femoral artery, and adenovirus expressing human PTEN type 1 (AdPTEN) or Escherichia coli ␤-galactosidase (AdLacZ) was injected between the cuff and the adventitia. After 14 days, the arteries were examined histopathologically and by Western blotting. The significant reduction of neointima formation by AdPTEN compared with AdLacZ was accompanied by reduced cell proliferation and increased adventitial cell apoptosis. AdPTEN also reduced expression of phosphorylated IB-␣, but not nonphosphorylated IB-␣. Western blotting revealed that AdPTEN reduced the cuff injury-induced expression levels of monocyte chemoattractant protein-1, TNF-␣, and IL-1␤ and their expression in all layers of the arterial wall. In contrast, cuff-induced macrophage invasion, which was also inhibited by AdPTEN, was detected only at the intimal surface and in the adventitia. In cultured vascular smooth muscle cells, PTEN directly inhibited ANG IIinduced monocyte chemoattractant protein-1 expression as quantified by real-time PCR and Western blotting. Our results suggest that overexpression of PTEN reduces neointima formation, possibly in part through inhibition of the inflammatory response by macrophage invasion and proinflammatory cytokine expression. vascular inflammation; monocyte chemoattractant protein-1; gene transfer PHOSPHATASE AND TENSIN homology deleted on chromosome 10 (PTEN) is a multifunctional lipid phosphatase that was originally identified as a tumor suppressor gene (20,22). In addition to its tumor suppression capability, it is also known to modulate several cell functions, including migration, proliferation, and apoptosis (36). These actions of PTEN are mediated by antagonism of the phosphatidylinositol 3-kinase (PI3K)-mediated signaling pathway (22). Moreover, PTEN also has protein tyrosine phosphatase activity, which downmodulates signaling pathways involving focal adhesion kinase (FAK) or Shc (34,36). Modulation of FAK/Shc activity by PTEN affects cell migration and adhesion activated by integrins and other tyrosine kinase receptors (34, 36). PTEN has recently been found to play an essential role in cells of the cardiovascular system (25). PTEN is expressed endogenously and regulates many cell functions in cardiomyocytes, fibroblasts, endothelial cells, and vascular smooth muscle cells (VSMCs), including proliferation, migration, survival/apoptosis, hypertrophy, contractility, metabolism, and mechan...

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“…C-reactive protein, CRP) w surowicy przed zabiegiem wszczepienia stentu w stosunku do pacjentów z prawidłową jego wartością [13]. Wyniki te potwierdzili inni badacze [14][15][16][17][18][19]. Obecnie stan zapalny istniejący zarówno przed wszczepieniem, jak i po wszczepieniu stentu uznaje się za niezależny czynnik ryzyka wystąpienia restenozy.…”

Section: Mechanizm Restenozyunclassified

Drug eluting stent or drug eluting balloon? Which is the better device to treat instent restenosis?

Skoczyńska¹,

Ochała²,

Dworowy³

et al. 2011

pwki

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Preprocedural serum levels of acute-phase reactants and prognosis after percutaneous coronary intervention

Abstract: Our study clearly supports the role of inflammation in restenosis after PCI as measured in statistically higher levels of Lp(a) and fibrinogen in patients with MACE and CRP in patients with repeat angina.

Cited by 67 publications

References 28 publications

Predictive Value of C-Reactive Protein for Major Postoperative Complications Following Off-Pump Coronary Artery Bypass Surgery Prospective and Observational Trial

Predictive Value of C-Reactive Protein for Major Postoperative Complications Following Off-Pump Coronary Artery Bypass Surgery Prospective and Observational Trial

PTEN reduces cuff-induced neointima formation and proinflammatory cytokines

Drug eluting stent or drug eluting balloon? Which is the better device to treat instent restenosis?

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