Prepregnancy Obesity and Birth Outcomes

Averett, Susan L.; Fletcher, Erin K.

doi:10.1007/s10995-015-1865-0

Cited by 24 publications

(22 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings help to explain the inconsistent findings between pre-pregnancy BMI and PTB outcomes reported in previous studies202122232425262728 and suggest that such inconsistency may be partly due to the interactions between maternal genotype (that is, rs11161721) and pre-pregnancy BMI. We showed that the impact of pre-pregnancy BMI on overall PTB risk depends on the maternal genotype at rs11161721.…”

Section: Discussionsupporting

confidence: 51%

“…First, maternal pre-pregnancy overweight/obesity (OWO) is prevalent in the BBC (>50%), which is significant from clinical and public health perspectives, and also ensures sufficient statistical power to identify a significant G × E interaction in this study. In addition, previous studies on the associations of pre-pregnancy BMI or OWO with PTB have yielded inconsistent results, including positive20212223, null2425 or negative associations262728. It is possible that such inconsistent findings may be in part due to maternal gene × pre-pregnancy BMI interaction29, which is largely unexplored.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Genome-wide approach identifies a novel gene-maternal pre-pregnancy BMI interaction on preterm birth

et al. 2017

View full text Add to dashboard Cite

Preterm birth (PTB) contributes significantly to infant mortality and morbidity with lifelong impact. Few robust genetic factors of PTB have been identified. Such ‘missing heritability' may be partly due to gene × environment interactions (G × E), which is largely unexplored. Here we conduct genome-wide G × E analyses of PTB in 1,733 African-American women (698 mothers of PTB; 1,035 of term birth) from the Boston Birth Cohort. We show that maternal COL24A1 variants have a significant genome-wide interaction with maternal pre-pregnancy overweight/obesity on PTB risk, with rs11161721 (PG × E=1.8 × 10−8; empirical PG × E=1.2 × 10−8) as the top hit. This interaction is replicated in African-American mothers (PG × E=0.01) from an independent cohort and in meta-analysis (PG × E=3.6 × 10−9), but is not replicated in Caucasians. In adipose tissue, rs11161721 is significantly associated with altered COL24A1 expression. Our findings may provide new insight into the aetiology of PTB and improve our ability to predict and prevent PTB.

show abstract

Section: Discussionsupporting

confidence: 51%

mentioning

confidence: 99%

Genome-wide approach identifies a novel gene-maternal pre-pregnancy BMI interaction on preterm birth

et al. 2017

View full text Add to dashboard Cite

show abstract

“…However, the estimators were robust when the analysis was refined to those women who attended their first visit before 20 or 28 gestational weeks. Third, we do not have enough siblings with common mother to reduce potential confounding due to unobserved factors, such as genetic factors, smoking, and other individual characteristics as previous studies did [29,30].…”

Section: Discussion/conclusionmentioning

confidence: 99%

Prepregnancy Overweight and Obesity Are Associated with an Increased Risk of Preterm Birth in Chinese Women

Huang

et al. 2020

Obes Facts

View full text Add to dashboard Cite

Introduction: The association between obesity before pregnancy and preterm birth varies with age and ethnicity. Objective: To study the association between early body mass index (BMI) and risk of preterm birth in Chinese women. Methods: This was a hospital-based retrospective cohort study including 36,596 Chinese women who gave birth to a live singleton infant from 2015 to 2018. Women were classified as underweight (BMI < 18.5), normal weight (BMI 18.5 to < 23), overweight (BMI 23 to < 27.5), or obese (BMI ≥27.5) according to the most recent criteria for Asian women. Multivariate log-binomial regression models were used to estimate the relative risks (RRs) and 95% confidence intervals (95% CIs) for preterm birth among different groups. Results: Compared to women with normal weight, women with overweight or obesity before pregnancy had an increased risk of preterm birth; the RRs and 95% CIs were 1.22 (95% CI: 1.08-1.37) and 1.30 (95% CI: 1.01-1.69), respectively. The greatest risk of extremely preterm birth was observed in obese women. The estimators were robust when considering the maternal age and rate of gestational weight gain (GWG) during pregnancy. Conclusions: Women with overweight and obesity had an increased risk of preterm birth regardless of GWG in early pregnancy. Our study suggests that it is beneficial to lose weight before conception for both overweight and obese women who plan to become pregnant.

show abstract

“…9 On the contrary Averett et al found no association of maternal obesity and LGA babies. 10 However, since the present study was a retrospective analysis of hospital data, information regarding pre pregnancy body mass index and gestational weight gain was not available.…”

Section: Discussionmentioning

confidence: 99%

Maternal factors associated with large for gestational age babies and its outcome when compared with those of appropriate for gestational age

John

Rani

Ghose

2017

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

INTRODUCTIONFoetal macrosomia is a common obstetrical problem affecting 20% babies born at term.1 Conventionally babies with birth weight more than 90th percentile is considered to be large for gestational age and those between 5 th and 90 th percentile as appropriate for gestational age. The birth weight cut-off may be based on absolute birth weight or greater than a particular percentile for the babies of that gestational age.2 Large for gestational age babies can lead to complications during delivery like prolonged labour, shoulder dystocia, birth injuries, post-partum haemorrhage, increased need for caesarean sections for cephalopelvic disproportion, anaesthetic complications and thromboembolic events. Also neonatal adverse outcomes of hypoglycemia, hypomagnesemia and hyperbilirubinemia are more common in these babies. 4 Antenatal detection of large for gestational age foetus will be helpful in anticipating these complications. This study is undertaken to determine the maternal factors associated with this condition so that the complications can be anticipated and managed in a better manner if not prevented. METHODSThis study was conducted in a tertiary care center based on collection of retrospective data about large for gestational age (LGA) babies born over a period of one year. The inclusion criteria were singleton pregnancies which resulted in LGA babies over this period of time. All the mothers who delivered babies who were large for ABSTRACT Background: Large for gestational age (LGA) babies are known to have a higher incidence of birth trauma, difficult delivery and Caesarean sections. Knowledge about maternal factors associated with this can help in prediction and prevention of complications. Methods: Maternal factors in 112 cases of LGA babies was studied along with its outcome and compared with an equal number of controls. Results: 0.05% deliveries resulted in LGA babies. Age and parity were not significantly different in the two groups and so were the associated medical disorders of hypothyroidism and gestational hypertension. Significant association was found with post-dated pregnancies (p=0.04) and gestational diabetes mellitus (p=0.05). Also, higher number of primary Caesarean sections resulted in the case group. Conclusions: Post dated pregnancies and gestational diabetes were maternal factors associated with LGA babies and higher number of primary Caesarean sections resulted in these cases.

show abstract

Prepregnancy Obesity and Birth Outcomes

Cited by 24 publications

References 29 publications

Genome-wide approach identifies a novel gene-maternal pre-pregnancy BMI interaction on preterm birth

Genome-wide approach identifies a novel gene-maternal pre-pregnancy BMI interaction on preterm birth

Prepregnancy Overweight and Obesity Are Associated with an Increased Risk of Preterm Birth in Chinese Women

Maternal factors associated with large for gestational age babies and its outcome when compared with those of appropriate for gestational age

Contact Info

Product

Resources

About