Preponderance of endometrial carcinoma in elderly patients

Abstract

Elderly patients with endometrial carcinoma (EMC) are considered to have a poor clinical outcome. The present study included 79 patients aged ≥70 years with EMC stage I or II according to the International Federation of Gynecology and Obstetrics classification, and it was conducted to analyse the clinicopathological significance of histological type (I or II), depth of myometrial invasion (<1/2 or ≥1/2), lymphovascular invasion (+ or -) and immunohistochemical profile. The aim of these analyses was to determine whether these factors may adversely affect the patient outcome and the underlying mechanisms. The immunohistochemical markers used were estrogen receptor (ER), Ki-67 and p53. The expression of these markers was evaluated as high (+) or low (−). Accordingly, the patients were divided into groups as follows: 54 cases type I vs. 25 cases type II; 48 cases with myometrial invasion <1/2 vs. 31 cases without myometrial invasion ≥1/2; 63 cases with lymphovascular invasion vs. 16 cases without lymphovascular invasion; 57 cases with ER (+) vs. 22 cases with ER (−); 24 cases with Ki-67 (+) vs. 55 cases with Ki-67 (−); and 29 cases with p53 (+) vs. 50 cases with p53 (−). In conclusion, close attention must be paid to elderly patients with EMC due to the tumor's intrinsic aggressiveness, which may include the ER (−) and p53 (+) pattern as an independent poor prognostic factor.

<p>TRIB3 suppresses proliferation and invasion and promotes apoptosis of endometrial cancer cells by regulating the AKT signaling pathway</p>

“…Endometrial cancer (EC) is one of the common malignant genital tumors in female characterized by high recurrence and adverse outcomes. Its morbidity and mortality have presented an ascending trend in the last few years, and it is reported that it occurs over a wide range of age groups from young individuals to elderly women 1,2. Surgery, chemotherapy, and radiotherapy have been considered as effective treatments for EC 3,4.…”

Endometrial endometrioid carcinoma, grade 1, is more aggressive in the elderly than in the young

“…13 Furthermore, Ogane et al reported that ER-negative/p53-positive status is independently associated with a poor prognosis in elderly people with endometrial cancer. 27 However, these studies also differed from ours in that G3 endometrioid carcinoma and other high-grade adenocarcinomas were included in their analyses of the prognostic significance of age and aberrant p53 expression. Moreover, Yano et al reported that the prognosis of G1 endometrioid carcinoma in the elderly with aberrant p53 expression is equivalent to that of conventional G3 endometrioid carcinoma.…”

Discovery of highly potent and selective 7-ethyl-10-hydroxycamptothecin-glucose conjugates as potential anti-colorectal cancer agents

“…In the in vitro study, we found that 5b could inhibit cell proliferation and induce apoptosis in HCT116 cells. Ki-67 and cleaved caspase-3 (CC3) are excellent markers of proliferating and apoptotic cells, respectively (Ogane et al, 2018). To detect the effect of 5b on Ki-67 and CC3 in the tumor tissues, immunohistochemical analysis was performed using anti-Ki-67 and anti-CC3 monoclonal antibodies.…”