Preponderance of blood group B among dengue fever patients with serious complications in a tertiary care hospital

Bulugahapitiya, D U S; Satarasinghe, Ravindra

doi:10.4038/cmj.v48i3.3358

Cited by 9 publications

(9 citation statements)

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“…Moreover, according to a more recent study, clinically apparent DENV infection is more common in blood group O, however, DHF is not associated with any blood groups in their study sample [9]. Majority of our patients had blood group B and this finding is in agreement with the observations made in the Colombo District, the Western Province of Sri Lanka [3] although that study did not report have any association of blood group B with DHF. There is paucity of research on the reasons for why individuals with some blood groups are more susceptible to DF and DHF.…”

supporting

confidence: 91%

“…Several factors such as viral and host factors are believed to contribute to the development of dengue haemorrhagic fever (DHF) and dengue shock syndrome following a dengue virus (DENV) infection. Although the pathogenic mechanisms involved in the development of DHF/DSS are not fully understood, host factors including ABO blood groups have been shown to be associated with severity of DENV infection [3,7,9,11]. There seems to be some protection against infectious diseases from inheritance of polymorphisms in genes encoding and regulating the expression of ABH and Lewis antigens in the body secretions.…”

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confidence: 99%

“…When conducting such studies it is important to consider the blood group distribution of the local population where the study sample is recruited. Previous studies from Sri Lanka [3,11], Thailand [7] and India [9] have not taken this into account. If the blood group distribution of the local population from which the study samples were recruited is not taken into account, the findings of those studies cannot be compared with the current study findings.…”

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confidence: 99%

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Blood group AB is associated with severe forms of dengue virus infection

et al. 2018

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Several viral and host factors are believed to contribute to the development of severe forms of dengue such as dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS) following a dengue virus (DENV) infection. The pathogenesis of DHF/DSS is not fully understood, however, host factors like ABO blood groups have been shown to contribute to the severity of DENV infection. The present study investigated the association of blood groups with severity of DENV infection in the northern region of Sri Lanka. The blood-groups of 405 patients positive for DENV NS1 antigen and anti-DENV IgM/IgG were determined using the standard haemagglutination assay recommended by the national blood bank/s. The occurrence of severe dengue in patients with certain blood groups was significantly different ( < 0.001) to those with other blood groups. Patients with AB blood group had more than 2.5 times higher risk of developing DHF than those with other blood groups. On the other hand, patients with blood group O were significantly under represented for DHF relative to the proportion of this blood group in the general population. Thus dengue patients with blood group O appear to have a low risk of developing DHF than those with other blood groups.

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confidence: 91%

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confidence: 99%

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confidence: 99%

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Blood group AB is associated with severe forms of dengue virus infection

et al. 2018

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“…Our study revealed that blood group B showed the maximum number of cases with increased hematocrit, leucopenia, severe thrombocytopenia and lymphocytosis compared to other blood groups and thus was a predictor of severe dengue in accordance with claims of few studies. 9,13,14 While ours is the only study analyzing hematological findings and association with blood group, all the other studies derived its association by comparing prevalence of blood groups in Dengue fever and Dengue haemorrhagic fever and noted increased prevalence of B group in severe forms of dengue.…”

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confidence: 88%

“…3,7,8,10,11 A few studies have focused on association of Dengue infection and blood groups, while some have reported increased prevalence of certain blood groups in dengue, others have noted an association of certain blood group with severity of Dengue. 3,7,9,[12][13][14] However, reports are varied among the different studies, none of which have correlated the blood group with each of the hematological parameters which are affected in dengue. Our study focuses on the association of blood group and dengue, its prevalence and severity as knowledge of risk factors can prove to be vital for prevention and management.…”

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Impact of blood group in dengue: a study

et al. 2019

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Background: Dengue can result in high mortality. Several studies have shown an association of blood groups with the severity of dengue. In our study we attempt to associate the prevalence of blood groups with the known hematological prognosticators and thus derive its impact on the severity of dengue. We aim to study the patterns and prevalence of different ABO blood groups in dengue fever.Methods: A total of 100 serologically proven dengue cases over a month’s period in November 2016 were recruited for our study. Their relevant hematological data (obtained by automated haematology analyser and peripheral smears) and blood grouping results were recorded and analyzed.Results: The age range was 5 months to 65 years with a slight male predominance. Analysis of the blood group patterns showed prevalence of O group (42%) followed by A and B group (27% each). B group was more prevalent in children (34%) and females (31%) with dengue.The patients with B group showed increased derangement in hematological parameters namely higher number of cases with B group showed rise in haematocrit (59%), an increased number of cases with leucopenia (56%), higher proportion of cases with lymphocytosis (45%) and severe thrombocytopenia (74%) when compared to the other blood groups.Conclusions: Our study shows that blood groups can impact severity of dengue and that B group is a risk factor for severity hence, such individuals warrant close supervision especially in the presence of other risk factors.

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Association of dengue disease severity and blood group: A systematic review and meta‐analysis

Hashan

Ghozy

El‐Qushayri

et al. 2020

Reviews in Medical Virology

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Summary Dengue disease encompasses various clinical manifestations including dengue fever (DF) and dengue hemorrhagic fever (DHF). In this article, we aimed to systematically review and analyze the association between different blood groups and severity of dengue. We searched nine databases for eligible papers reporting prevalence, distribution, and frequency of blood group type among dengue patients. Network meta‐analysis using R software was used to analyze the data. Of a total of 63 reports screened, we included 10 studies with total sample size 1977 patients (1382 DF and 595 DHF). Blood group O was found to have the worst outcome with the highest risk of developing DF (P‐score = 0.01) followed by group B (P‐score = 0.34), group A (P‐score = 0.64), and group AB (P‐score = 1), respectively. Blood group O also had the worst outcome with highest risk of developing DHF (P‐score = 0.1) followed by group B (P‐score = 0.29), group A (P‐score = 0.61), and group AB (P‐score = 1), respectively. There was a significant increase (P‐value <.001) in the overall odds risk of dengue infection among patients with Rhesus‐positive blood groups [OR = 540.03; (95% CI = 151.48‐1925.18)]. However, there was no significant difference in the odds risk of DF when compared to DHF according to Rhesus status (P‐value = .954). This study identified the O blood group as a potential risk factor in predicting clinical severity in dengue patients which may be helpful in evaluating patients for their likely need for critical care.

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Preponderance of blood group B among dengue fever patients with serious complications in a tertiary care hospital

Cited by 9 publications

References 0 publications

Blood group AB is associated with severe forms of dengue virus infection

Blood group AB is associated with severe forms of dengue virus infection

Impact of blood group in dengue: a study

Association of dengue disease severity and blood group: A systematic review and meta‐analysis

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