Preperitoneal Continuous Infusion of Local Anesthetics: What Is the Impact on Surgical Wound Infections in Humans?

Claroni, Claudia; Marcelli, Maria Elena; Sofra, Maria; Covotta, Marco; Torregiani, Giulia; Giannarelli, Diana; Forastiere, Ester

doi:10.1111/pme.12872

Cited by 6 publications

(5 citation statements)

References 34 publications

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“…Two patients had wound infection in the CLAWI arm. Despite this, our infection rates were lower than the described range of 13.8–23.5% in the literature [41, 42]. Both patients had superficial surgical site infections that resolved with conservative treatment.…”

Section: Discussioncontrasting

confidence: 73%

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Effectiveness of Pain Control of Local Anaesthetic Wound Infusion Following Elective Midline Laparotomy: A Randomized Trial

et al. 2021

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Background Post-operative pain control is an important pillar in enhanced recovery after surgery. There is a paucity of data that compares efficacy of pain control between continuous local anaesthetic wound infusion and thoracic epidural analgesia in elective midline laparotomy patients Objective To evaluate pain control between continuous local anaesthetic wound infusion and thoracic epidural analgesia in elective laparotomy patients. Design A randomized, single-blind, controlled clinical trial.

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Section: Discussioncontrasting

confidence: 73%

“…Two patients had wound infection in the CLAWI arm. Despite this, our infection rates were lower than the described range of 13.8-23.5% in the literature [41,42]. Fig.…”

Section: Rates Of Adverse Effectscontrasting

confidence: 71%

Effectiveness of Pain Control of Local Anaesthetic Wound Infusion Following Elective Midline Laparotomy: A Randomized Trial

et al. 2021

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“…The definition of SSI was based on Southampton Wound Assessment Scale. 14 Grade I, II, were not considered infections and grade III,IV,V and VI were taken as infections when it occurred beneath the muscle's incision area and the muscle's tissues. Mortality was recorded as patient's death from 1 st day of surgery to 4 months following surgery, either as inpatient or outpatient.…”

Section: Methodsmentioning

confidence: 99%

Lead the way or leave the way: Early experience of management of emergency pelvi-acetabular surgery during the COVID-19 pandemic at a tertiary care hospital in Pakistan.

Nadeem

Ali

Shakoor

et al. 2022

TPMJ

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Objective: To report the early experience, the relationship of surgical site infection after pelvi-acetabular fracture fixation with certain possible risk factors, and organizational protocol for emergency pelvic surgery currently being used during the COVID-19 pandemic by an integrated team of orthopedic surgeons. Study Design: Prospective study. Setting: Department of Orthopedic and Spine Surgery, “Ghurki Trust Teaching Hospital Lahore, Pakistan. Period: March 2020, to August 2020. Material & Methods: A total of 25 patients diagnosed with acetabular fractures were included. Fracture patterns were classified according to judet and letournel and young burgess classification systems. Factors studied included patient’s age, gender, body mass index, fracture pattern, type of surgery, comorbidities, smoking status, associated injuries, surgical site infections and mortality. Results: In a total of 25 patients, 21(84.0%) were male and 4(16.0%) female patients with overall mean age as 38.04±14.58 years. Overall, mean BMI was 23.20±2.60 kg/m2. There were 12(48.0%) patiens who had hypertension while 4 (16.0%) smokers. There were 21 (84.0%) patients who did not have any associated injuries while 3 (12.0%) had the associated extremities. The mean hospital stay of the patients was 5.08±0.76 days. The results revealed no significant association of Gender with these parameters (p > 0.001). Conclusion: There is no added risk of infection and mortality for the provision of emergency trauma services to pelvi-acetabular fractured patients even during panic and pandemic situations.

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“…Nagy hasi (máj, pancreas) műtétet követően peritonealisan, folyamatos infúzióban adott 0,2%-os ropivakain nem befolyásolta a SSI gyakoriságát [43]. Korábbi in vitro munka már bizonyította, hogy a 0,2%-os ropivakainnak korlátozott antibakteriális hatása lehet, de az E. coli csíraszáma 3 óra után emelkedik benne [31].…”

Section: Helyi éRzéstelenítők Hatása a Sebfertőzésekreunclassified

Helyi érzéstelenítők antibakteriális hatása

Szabó

Szentkiralyi

Kovács³

et al. 2021

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Összefoglaló. Gyógyszereink egy részének jelentős, az eredeti alkalmazástól eltérő hatása is van. Ezek felismerése fontos, hogy elkerüljük a nem várt mellékhatásokat, vagy kihasználjuk ezeket a kedvező adottságokat. A helyi érzéstelenítők antibakteriális hatása 1909 óta ismert, de ennek több évtizeden keresztül nem tulajdonítottak jelentőséget. Az 1960-as években figyeltek fel először az álnegatív mikrobiológiai eredmények lehetőségére, helyi érzéstelenítőket használva a mintavételhez. Tanulmányok igazolták, hogy a bronchoszkópiás, seb-, bőr- vagy fül-, orr-, gégészeti bakteriológiai eredmények is érintve lehetnek. A ma is használt gyógyszerek közül a 0,5%-os bupivakainnak és a 2%-os lidokainnak van jelentős antibakteriális hatása Gram-pozitív és Gram-negatív baktériumokkal szemben, ami kifejezettebb 37 °C-on, mint szobahőmérsékleten. A legerősebb antibakteriális hatást a 0,5%-os bupivakain mutatta. A napi gyakorlatban alkalmazott koncentrációjuk magasabb, mint a különböző klinikai izolátumokkal szemben meghatározott minimális gátló koncentráció. Fenti tulajdonságaik alapján felmerült szerepük a kórházi sebfertőzések csökkentésében is. A hatásmechanizmus több pontja ismert, károsítják a sejthártya integritását, és több bakteriális enzim működését gátolják. Orv Hetil. 2021; 162(5): 171–176. Summary. Medications may have important impacts other than the original effect. It is important to know about these to avoid side effects or use these beneficial capabilities. The antibacterial effect of local anaesthetics has been known since 1909. For decades, no attention has been payed to this fact. In the 1960s, the high number of negative microbiological results when local anaesthetics were used before sampling drew attention to the possible antibacterial effect. Studies suggested that cultures from bronchoscopy, wound, skin or nasal samples may be affected. Bupivacaine 0,5% and lidocaine 2% have the most noticeable effect against both Gram-positive and Gram-negative bacteria. This impact is more pronounced at 37 °C than at room temperature. Bupivacaine 0,5% has the most pronounced effect. The concentration of local anaesthetics in daily routine is higher than the minimal inhibitory concentration against various clinical isolates. In the view of these results, they may contribute to reduce surgical site infections. There are known details regarding the mechanism of action. Local anaesthetics have target sites on cellular membrane and inhibit bacterial enzymes. Orv Hetil. 2021; 162(5): 171–176.

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Preperitoneal Continuous Infusion of Local Anesthetics: What Is the Impact on Surgical Wound Infections in Humans?

Cited by 6 publications

References 34 publications

Effectiveness of Pain Control of Local Anaesthetic Wound Infusion Following Elective Midline Laparotomy: A Randomized Trial

Effectiveness of Pain Control of Local Anaesthetic Wound Infusion Following Elective Midline Laparotomy: A Randomized Trial

Lead the way or leave the way: Early experience of management of emergency pelvi-acetabular surgery during the COVID-19 pandemic at a tertiary care hospital in Pakistan.

Helyi érzéstelenítők antibakteriális hatása

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