Preperation and Characterization of Allyl Modified Guar-Gum

Gupta, A. P.; Arora, Gopal

doi:10.15373/22778179/march2014/9

Cited by 2 publications

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“…A different study shows the production of GG-PVA films using citric acid as additive. Interestingly, when films were dried at a low temperature, the physical properties of the films were improved due to the activation of hydrogen bonding (Gupta 2012). Further, the emulsion process has been employed to produced GG nanoparticles loaded with Tamoxifen citrate (TMX).…”

Section: Cross-linking Of Naturally Occurring Gumsmentioning

confidence: 99%

Improved Polymer Functionality by Cross-linking with Glutaraldehyde to Achieve Controlled Drug Release

Rojas

2015

Excipient Applications in Formulation Design and Drug Delivery

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There are many approaches to combine drug and polymers. One of them involves the use of drug-polymer conjugates in which the drug is covalently bounded to a polymer through a hydrolyzable linkage. However, the most widely used approach involves polymers as matrixes in which the drug and polymer are mixed physically and the release is achieved by diffusion from the surrounding polymeric matrix or by disintegration of the polymeric matrix. Nevertheless, most biopolymers per se do not possess adequate physicochemical and mechanical properties to produce a film or hydrogel which can be used as a matrix for the controlled release of drugs. For this reason, many cross-linking agents have been used to improve these polymer properties. The most reactive and typical cross-linking agent employed is glutaraldehyde. This chapter discusses the modification of drug release properties of polymers suchs as poly(vinyl) alcohol, chitosan, gelatin, alginates, carrageenan and naturally occurring gums by chemical modification via glutaraldehyde cross-linking. Most cross-linked products are more amorphous due to the reduction of the hydroxyl network responsible for cross-linking, crystallinity and water interaction.

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Section: Cross-linking Of Naturally Occurring Gumsmentioning

confidence: 99%

Improved Polymer Functionality by Cross-linking with Glutaraldehyde to Achieve Controlled Drug Release

Rojas

2015

Excipient Applications in Formulation Design and Drug Delivery

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Recent Progress in Chemical Modification of the Natural Polysaccharide Guar Gum

Kaur

Santra

2022

COS

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: Guar gum (GG) is a natural heteropolysaccharide. Due to its non-toxic, eco-friendly, and biodegradable nature, GG has found wide applications in many areas, in particular food, paper, textile, petroleum, and pharmaceutical industries. Therefore, GG is often called “Black Gold” as well. Due to the presence of hydroxyl groups, GG can be modified by various methods. The physical and biological properties of GG can be modulated by chemical modifications. In this manuscript, various methods for the chemical modifications of GG have been discussed according to the type of modifications. Mechanistic insights have also been provided whenever possible. In addition, potential applications of new GG derivatives have also been briefly mentioned.

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Preperation and Characterization of Allyl Modified Guar-Gum

Cited by 2 publications

References 0 publications

Improved Polymer Functionality by Cross-linking with Glutaraldehyde to Achieve Controlled Drug Release

Improved Polymer Functionality by Cross-linking with Glutaraldehyde to Achieve Controlled Drug Release

Recent Progress in Chemical Modification of the Natural Polysaccharide Guar Gum

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