“…Despite the substantial improvement of obstetric diagnostic and therapeutic methods, accumulating evidence suggests that advanced maternal age (AMA) is still associated with adverse outcomes of pregnancy, including high percentage of spontaneous abortion (SA) and gestational hypertension (GH) [1][2][3], intrauterine growth restriction, neonatal low-birth weight (LBW; \2,500 g) and small fetus for the gestational age (SGA; \10th %) [4,5], preterm delivery (PTD; \37 weeks) [6], twin pregnancies [particularly after assisted reproductive technologies (ART)] [1][2][3], endouterine fetal death [7,8], chromosomal aberrations [9][10][11], need of cesarean section [12][13][14]. In particular, risks associated with delayed childbearing become significant for maternal age greater than 35 years [15,16].…”